The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
The role of galectins in immunity and infection
Open accessAbstract
The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in the nucleus or the cytoplasm, or can be secreted into the extracellular space. They can modulate innate and adaptive immune cells by binding to glycans on the surface of immune cells or intracellularly via carbohydrate-dependent or carbohydrate-independent interactions. Galectins expressed by immune cells can also participate in host responses to infection by directly binding to microorganisms or by modulating antimicrobial functions such as autophagy. Here we explore the diverse ways in which galectins have been shown to impact immunity and discuss the opportunities and challenges in the field. Galectins can modulate immune cells by binding to glycosylated proteins and lipids on the cell surface, or intracellularly via carbohydrate-dependent or carbohydrate-independent interactions. This Review explores the diverse ways in which galectins affect immunity and discusses the challenges in the field.
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Citations
Cites
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Zhu, C., Anderson, A. C., Schubart, A., Xiong, H., Imitola, J., Khoury, S. J., Zheng, X. X., Strom, T. B., & Kuchroo, V. K. (2005) · Nature Immunology · doi:10.1038/ni1271 · Cited by 2,057
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Murali-Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,943
SOCS proteins, cytokine signalling and immune regulation
Yoshimura, A., Naka, T., & Kubo, M. (2007) · Nature Reviews Immunology · doi:10.1038/nri2093 · Cited by 1,580
Apoptosis of T cells mediated by galectin-1
Perillo, N. L., Pace, K. E., Seilhamer, J. J., & Baum, L. G. (1995) · Nature · doi:10.1038/378736a0 · Cited by 1,074
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
Thurston, T. L. M., Wandel, M. P., von Muhlinen, N., Foeglein, Á., & Randow, F. (2012) · Nature · doi:10.1038/nature10744 · Cited by 1,034
Oligosaccharide specificity of galectins: a search by frontal affinity chromatography
Hirabayashi, J., Hashidate, T., Arata, Y., Nishi, N., Nakamura, T., Hirashima, M., Urashima, T., Oka, T., Futai, M., Muller, W. E. G., et al. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00311-2 · Cited by 926
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
Rabinovich, G. A., & Toscano, M. A. (2009) · Nature Reviews Immunology · doi:10.1038/nri2536 · Cited by 904
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
Demetriou, M., Granovsky, M., Quaggin, S., & Dennis, J. W. (2001) · Nature · doi:10.1038/35055582 · Cited by 901
Expression of galectin-3 modulates T-cell growth and apoptosis.
Yang, R. Y., Hsu, D. K., & Liu, F. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6737 · Cited by 789
Self-citationToscano, M. A., Bianco, G. A., Ilarregui, J. M., Croci, D. O., Correale, J., Hernandez, J. D., Zwirner, N. W., Poirier, F., Riley, E. M., Baum, L. G., et al. (2007) · Nature Immunology · doi:10.1038/ni1482 · Cited by 653
Cited by
Quinn, J., Salman, A., Paluch, C., Jackson-Wood, M., McClements, M. E., Luo, J., Davis, S. J., Cornall, R. J., MacLaren, R. E., Dendrou, C. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-68401-y · Cited by 32
Metadata
- Authors
- Liu, F.-T., & Stowell, S. R.
- Venue
- Nature Reviews Immunology
- Published
- 2023-01-16
- Volume
- 23
- Issue
- 8
- Pages
- 479-494
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W4316500155
- Cited by
- 313
- References
- 165
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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