The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Antibiotic perturbations to the gut microbiome
Open accessAbstract
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome is a complex ecological network of microorganisms, the effects of antibiotics can be highly variable. With the advent of multi-omic approaches for systems-level profiling of microbial communities, we are beginning to identify microbiome-intrinsic and microbiome-extrinsic factors that affect microbiome dynamics during antibiotic exposure and subsequent recovery. In this Review, we discuss factors that influence restructuring of the gut microbiome on antibiotic exposure. We present an overview of the currently complex picture of treatment-induced changes to the microbial community and highlight essential considerations for future investigations of antibiotic-specific outcomes. Finally, we provide a synopsis of available strategies to minimize antibiotic-induced damage or to restore the pretreatment architectures of the gut microbial community.
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“Median times to pathogen identification with standard techniques have been reported near 96 h, a critical window during which unnecessary antimicrobial exposure can increase adverse events and the risk of colonization by resistant organisms (3–5).”
From Optimized use of the FilmArray Meningitis/Encephalitis panel for early discontinuation of antibiotic therapy (2026) · cites this paper as [4]
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Cites
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BackgroundGlobal increase and geographic convergence in antibiotic consumption between 2000 and 2015
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Cited by
Sorted by citations
Hays, K. E., Pfaffinger, J. M., & Ryznar, R. J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2393270 · Cited by 541
Mechanism of staphylococcal resistance to clinically relevant antibiotics
Brdová, D., Ruml, T., & Viktorová, J. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101147 · Cited by 144
Antimicrobial resistance crisis: could artificial intelligence be the solution?
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“Compared to antibiotics, which are mostly broad-spectrum, phage therapy offers remarkably higher specificity, minimizing disturbances to the microbiota and preventing antibiotic-induced AMR dissemination [136, 137].”
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Abeltino, A., Hatem, D., Serantoni, C., Riente, A., Giulio, M. M. D., Spirito, M. D., Maio, F. D., & Maulucci, G. (2024) · Nutrients · doi:10.3390/nu16223806 · Cited by 121
“[90–92] Environmental and lifestyle Both macroenvironmental (e.g., toxic exposure, socioeconomic status) and microenvironmental factors (e.g., smoking, diet, stress) can disrupt microbiome composition, promoting inflammation and long-term disease development.”
Engelsberger, V., Gerhard, M., & Mejías‐Luque, R. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1339750 · Cited by 110
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BackgroundInfluential
Metadata
- Authors
- Fishbein, S. R. S., Mahmud, B., & Dantas, G.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dantas, Gautam
- Venue
- Nature Reviews Microbiology
- Published
- 2023-07-25
- Volume
- 21
- Issue
- 12
- Pages
- 772-788
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC12087466
- OpenAlex
- W4385240643
- Cited by
- 440
- References
- 229
- Citations by year
- 2026: 152 · 2025: 165 · 2024: 115 · 2023: 7
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- Centers for Disease Control and Prevention (R01OH011578)
- Agency for Healthcare Research and Quality (R01 HS027621)
- National Institute of Allergy and Infectious Diseases (U01AI123394, R01AI155893)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK077653)
- National Institute for Occupational Safety and Health (R01 OH011578)
- National Center for Complementary and Integrative Health (R01AT009741)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD092414)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, antibiotics, microbiome perturbation, microbiome recovery, gastrointestinal diseases, autoimmune disease, multi-omics profiling
- MeSH terms
- Gastrointestinal Microbiome, Anti-Bacterial Agents, Gastrointestinal Tract, Microbiota
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