Alzheimer disease and aducanumab: adjusting our approach

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Sevigny, J., Chiao, P., Bussière, T., Weinreb, P. H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016) · Nature · doi:10.1038/nature19323 · Cited by 3,059

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242

Microglial signatures and their role in health and disease

Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046

The A4 Study: Stopping AD Before Symptoms Begin?

Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 778

Preventing Alzheimer’s Disease

Selkoe, D. J. (2012) · Science · doi:10.1126/science.1228541 · Cited by 391

Research Advances in Chaperone-Mediated Autophagy (CMA) and CMA-Based Protein Degraders

Pan, Z., Huang, X., Liu, M., Jiang, X. L., & He, G. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02681 · Cited by 21

Identifying the Main Functional Pathways Associated with Cognitive Resilience to Alzheimer’s Disease

Pérez-González, M., Badesso, S., Lorenzo, E., Guruceaga, E., Pérez-Mediavilla, A., García-Osta, A., & Cuadrado-Tejedor, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179120 · Cited by 16

Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease

Chen, Y., Therriault, J., Luo, J., Ba, M., Zhang, H., & Initiative, A. D. N. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2004088 · Cited by 19

Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development

Wang, B., Kobeissy, F. H., Golpich, M., Cai, G., Li, X., Abedi, R., Haskins, W. E., Tan, W., Benner, S. A., & Wang, K. (2024) · Molecules · doi:10.3390/molecules29051124 · Cited by 25

Immune Modulation in Alzheimer’s Disease: From Pathogenesis to Immunotherapy

Balkhi, S., Spirito, A. D., Poggi, A. D., & Mortara, L. (2025) · Cells · doi:10.3390/cells14040264 · Cited by 21

Hyperoside improves learning and memory deficits by amyloid β1-42 in mice through regulating synaptic calcium-permeable AMPA receptors

Yi, J. H., Moon, S., Cho, E., Kwon, H., Lee, S., Jeon, J., Park, A. Y., Lee, Y. H., Kwon, K. J., Ryu, J. H., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175188 · Cited by 19

The Immune System as a Therapeutic Target for Alzheimer’s Disease

Zieneldien, T., Kim, J., Sawmiller, D. R., & Cao, C. (2022) · Life · doi:10.3390/life12091440 · Cited by 19

Natural products against tau hyperphosphorylation‐induced aggregates: Potential therapies for Alzheimer's disease

Basurto‐Islas, G., Diaz, M. C., Zavala-Ocampo, L. M., Martínez‐Herrera, M., & López-Camacho, P. Y. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.202400721 · Cited by 20

α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

Chiu, W., Kovacheva, L., Musgrove, R. E., Arien‐Zakay, H., Koprich, J. B., Brotchie, J. M., Yaka, R., Ben‐Zvi, D., Hanani, M., Roeper, J., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd3994 · Cited by 20

Autophagy in the mammalian nervous system: a primer for neuroscientists

Suomi, F., & McWilliams, T. G. (2019) · Neuronal Signaling · doi:10.1042/ns20180134 · Cited by 18

Hypothesis: Intravenous administration of mesenchymal stem cells is effective in the treatment of Alzheimer's disease

Shigematsu, K., Takeda, T., Komori, N., Tahara, K., & Yamagishi, H. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110572 · Cited by 20

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

Reinitz, F., Chen, E. Y., Nicolis di Robilant, B., Chuluun, B., Antony, J., Jones, R. C., Gubbi, N., Lee, K., Ho, W. H. D., Kolluru, S. S., et al. (2022) · eLife · doi:10.7554/elife.66037 · Cited by 18

Informed consent, therapeutic misconception, and clinical trials for Alzheimer's disease

Wilkins, J. M., & Forester, B. P. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5262 · Cited by 17

Repetitive transcranial magnetic stimulation in Alzheimer’s disease: effects on neural and synaptic rehabilitation

Ji, Y., Yang, C., Pang, X., Yan, Y., Wu, Y., Geng, Z., Hu, W., Hu, P., Wu, X., & Wang, K. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01201 · Cited by 19

Nonesterified fatty acids, cognitive decline, and dementia

Mukamal, K. J. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000656 · Cited by 16

Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease

Abou, M. B., Sun, L., & Wei, H. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200522204722 · Cited by 15

The Israel Registry for Alzheimer’s Prevention (IRAP) Study: Design and Baseline Characteristics

Ravona‐Springer, R., Sharvit‐Ginon, I., Ganmore, I., Greenbaum, L., Bendlin, B. B., Sternberg, S. A., Livny, A., Domachevsky, L., Sandler, I., Ben‐Haim, S., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200623 · Cited by 16

Synthesis and biological evaluation of benzimidazoles/1,3,5-triazine-2,4-diamine hybrid compounds: a new class of multifunctional alzheimer targeting agents

Karimian, S., Shekouhy, M., Pirhadi, S., Iraji, A., Attarroshan, M., Edraki, N., & Khoshneviszadeh, M. (2022) · New Journal of Chemistry · doi:10.1039/d2nj00371f · Cited by 15

Idebenone protects mitochondrial function against amyloid beta toxicity in primary cultured cortical neurons

Wang, H., Li, L., Jia, K., Wang, Q., Sui, S., Lin, Y., & He, Y. (2020) · Neuroreport · doi:10.1097/wnr.0000000000001526 · Cited by 14

Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology

Gauba, E., Sui, S., Tian, J., Driskill, C. M., Jia, K., Yu, C., Rughwani, T., Wang, Q., Kroener, S., Guo, L., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.09.018 · Cited by 15

Fighting fire with fire: The immune system might be key in our fight against Alzheimer’s disease

Dujardin, P., Vandenbroucke, R. E., & Hoecke, L. V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.01.004 · Cited by 14

Utility of spontaneous animal models of Alzheimer’s disease in preclinical efficacy studies

Zeiss, C. J. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03198-6 · Cited by 16

A Chronological Review of Potential Disease-Modifying Therapeutic Strategies for Alzheimer’s Disease

Ettcheto, M., Busquets, O., Espinosa-Jiménez, T., Verdaguer, E., Auladell, C., & Camins, A. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200211121416 · Cited by 13

Dynamic distribution of gut microbiota during Alzheimer's disease progression in a mice model

Zhu, J., Liu, S., Zhang, H., Zhao, W., Ding, J., Dai, R., Xu, K., He, C., Liu, J., Yang, L., et al. (2023) · Apmis · doi:10.1111/apm.13339 · Cited by 14

Use of lecanemab for the treatment of Alzheimer's disease: A systematic review

Hossain, M. F., Husna, A. U., & Kharel, M. (2024) · Brain and Behavior · doi:10.1002/brb3.3592 · Cited by 13

Immunotherapy in Alzheimer’s Disease: Current Status and Future Directions

Vashisth, K., Sharma, S., Ghosh, S., Babu, M. A., Ghosh, S., Iqbal, D., Kamal, M., Almutary, A. G., Jha, S. K., Ojha, S. K., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230603 · Cited by 13

Immunogenicity of MultiTEP platform technology-based Tau vaccine in non-human primates

Hovakimyan, A., Zagorski, K., Chailyan, G., Antonyan, T., Melikyan, L., Petrushina, I., Batt, D. G., King, O., Ghazaryan, M., Donthi, A., et al. (2022) · npj Vaccines · doi:10.1038/s41541-022-00544-3 · Cited by 14

DNA Damage Increases Secreted Aβ40 and Aβ42 in Neuronal Progenitor Cells: Relevance to Alzheimer’s Disease

Welty, S., Thathiah, A., & Levine, A. S. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220030 · Cited by 13

Autoantibodies against the prion protein in individuals with PRNP mutations

Frontzek, K., Carta, M. C., Losa, M., Epskamp, M., Meisl, G., Anane, A., Brandel, J., Camenisch, U., Castilla, J., Haı̈k, S., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009183 · Cited by 13

Evaluation of Amyloid β42 Aggregation Inhibitory Activity of Commercial Dressings by A Microliter-Scale High-Throughput Screening System Using Quantum-Dot Nanoprobes

Kuragano, M., Yoshinari, W., Lin, X., Shimamori, K., Uwai, K., & Tokuraku, K. (2020) · Foods · doi:10.3390/foods9060825 · Cited by 12

Triheptanoin Mitigates Brain ATP Depletion and Mitochondrial Dysfunction in a Mouse Model of Alzheimer’s Disease

Yuan, X., Wang, L., Tandon, N., Sun, H., Tian, J., Du, H., Pascual, J. M., & Guo, L. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200594 · Cited by 12

The Hybrid Compounds as Multi-target Ligands for the Treatment of Alzheimer's Disease: Considerations on Donepezil

Gülcan, H. O., & Koşar, M. (2021) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026621666211111153626 · Cited by 12

Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial

Wunderlich, G. R., Blahova, Z., García, M., & Jessen, F. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01163-3 · Cited by 11

Effects of Current Psychotropic Drugs on Inflammation and Immune System

Bhatt, S., Dhar, A. K., Samanta, M. K., & Suttee, A. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_18 · Cited by 12

A highly sensitive hemicyanine-based near-infrared fluorescence sensor for detecting toxic amyloid aggregates in human serum

Warerkar, O. D., Mudliar, N. H., Ahuja, T., Shahane, S. D., & Singh, P. K. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125621 · Cited by 10

From the Gut to the Brain and Back: Therapeutic Approaches for the Treatment of Network Dysfunction in Parkinson's Disease

Paolone, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.557928 · Cited by 12

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

Zhang, G., Wu, J., Huang, C., Cheng, J., Su, Z., Zhu, Z., Yang, X., Guo, B., Wu, L., Zhang, Z., et al. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01762-x · Cited by 11

An integrated bioinformatics strategy to elucidate the function of hub genes linked to Alzheimer's disease

Sajad, M., Ahmed, M. M., & Thakur, S. C. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101534 · Cited by 11

Cholinesterases Inhibitory Activity of 1H-benzimidazole Derivatives

(2020) · Biointerface Research in Applied Chemistry · doi:10.33263/briac113.1073910745 · Cited by 11

Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta

Weigand, A. J., Edwards, L., Thomas, K. R., Bangen, K. J., Bondi, M. W., & Initiative, A. D. N. (2022) · Brain Communications · doi:10.1093/braincomms/fcac272 · Cited by 13

The endocrine pancreas of old obesehyperglycemic mice.

Westman, S. (1968) · PubMed · Cited by 11

Tau and β-Amyloid Relevant Pathology as a Central Therapeutic Target in Alzheimer’s Disease

Strużyńska, L., Adamiak, K., & Sidoryk‐Wȩgrzynowicz, M. (2026) · Biomolecules · doi:10.3390/biom16040595 · Cited by 9

Modulation of beta-amyloid aggregation using ascorbic acid

Sampaio, I., Quatroni, F. D., Lins, P. M. P., Nascimento, A. S., & Zucolotto, V. (2022) · Biochimie · doi:10.1016/j.biochi.2022.05.006 · Cited by 10

Association of early-onset Alzheimer’s disease with germline-generated high affinity self-antigen load

Huang, P.-Y. S., Yang, Y., Chang, Y.-H., Chang, S.-L., Chou, M., Lai, C., Liu, C., & Chen, H. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0826-6 · Cited by 10

Alzheimer Drug Trials: Combination of Safe and Efficacious Biologicals to Break the Amyloidosis-Neuroinflammation Vicious Cycle

Bartfai, T., & Lees, G. V. (2020) · ASN NEURO · doi:10.1177/1759091420918557 · Cited by 9

Ganglioside Nanocluster-Targeting Peptidyl Inhibitor Prevents Amyloid β Fibril Formation on the Neuronal Membrane

Matsubara, T., Nakai, M., Nishihara, M., Miyamoto, E., & Sato, T. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00047 · Cited by 8

The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders

Gribkoff, V. K., & Kaczmarek, L. K. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-21054-9_11 · Cited by 7

Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy

Levites, Y., Funk, C. C., Wang, X., Chakrabarty, P., McFarland, K. N., Bramblett, B., O’Neal, V., Liu, X., Ladd, T. B., Robinson, M., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00453-4 · Cited by 6

A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation

Prins, S., Zhuparris, A., Hart, E. P., Doll, R. J., & Groeneveld, G. J. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00874-9 · Cited by 8

Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease

Panwar, A., Khan, M. I. K., Kumar, R., Kumar, R., Kumar, S., & Kumar, A. (2024) · Advances in Alzheimer s Disease · doi:10.4236/aad.2024.133006 · Cited by 5

3D convolutional neural networks uncover modality-specific brain-imaging predictors for Alzheimer’s disease sub-scores

Ning, K., Bouchard-Cannon, P., Yu, J., Shenoi, S., Wang, L., Initiative, A. D. N., & Sarkar, J. (2024) · Brain Informatics · doi:10.1186/s40708-024-00218-x · Cited by 9

A Novel Explainability Approach for Technology-Driven Translational Research on Brain Aging

Turnbull, A. G., Kaplan, R. M., Adeli, E., & Lin, F. V. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220441 · Cited by 4

Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation

Guo, B., Zheng, C., Cao, J., Qiu, X., Luo, F., Li, H., Lee, S. M., Yang, X., Zhang, G., Sun, Y., et al. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08775-4 · Cited by 5

Dynamic analysis of synaptic loss and synaptic compensation in the process of associative memory ability decline in Alzheimer’s disease

Wang, W., He, C., Wang, Z., Hramov, A. E., Fan, D., Yuan, M., Luo, X., & Kurths, J. (2021) · Applied Mathematics and Computation · doi:10.1016/j.amc.2021.126372 · Cited by 5

ABTrans: A Transformer-based Model for Predicting Interaction between Anti-Aβ Antibodies and Peptides

Su, Y., Zeng, X., Zhang, L., Bian, Y., Wang, Y., & Ma, B. (2024) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-024-00664-5 · Cited by 3

Comprehending Alzheimer's Disease: Molecular Mechanisms and Treatment Strategies

Rathee, S., Pandey, V., Soni, S., Sen, D., & Jain, S. (2025) · Current Alzheimer Research · doi:10.2174/0115672050368798250626075628 · Cited by 6

Pericytes and the Neurovascular Unit: The Critical Nexus of Alzheimer Disease Pathogenesis?

Cercy, S. P. (2021) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2020.00062 · Cited by 4

Complex non‐Markovian dynamics and the dual role of astrocytes in Alzheimer’s disease development and propagation

Pal, S., & Melnik, R. (2025) · Quantitative Biology · doi:10.1002/qub2.70001 · Cited by 5

Early Diagnosis of Mild Cognitive Impairment with 2-Dimensional Convolutional Neural Network Classification of Magnetic Resonance Images

Angelopoulos, S. P. (2021) · Hawaii International Conference on System Sciences (HICSS) · doi:10.24251/hicss.2021.414 · Cited by 3

Characterizing brain imaging features associated with ADAS-Cog13 sub-scores with 3D convolutional neural networksPreprint

Ning, K., Bouchard-Cannon, P., Yu, J., Shenoi, S., Wang, L., Initiative, A. D. N., & Sarkar, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.17.484832 · Cited by 3

Active immunization: A novel therapeutic strategy for treating Alzheimer's disease

Mazahir, F. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178288 · Cited by 3

Alzheimer-Krankheit: Weshalb Therapieansätze so oft scheitern

Arendt, T. (2019) · Deutsches Ärzteblatt · doi:10.3238/persneuro.2019.09.13.05 · Cited by 2

Corneal Wound Healing in the Presence of Antifibrotic Antibody Targeting Collagen Fibrillogenesis: A Pilot Study

Syed, Z. A., Milman, T., Fertala, J., Steplewski, A., & Fertala, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713438 · Cited by 2

Alzheimer’s Disease: A Molecular Model and Implied Path to Improved Therapy

Weaver-Rosen, M., & Serwer, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063479 · Cited by 2

PHARMACOLOGICAL TREATMENT OF ALZHEIMER'S DISEASE: AN INTEGRATIVE REVIEW ON THE EFFECTIVENESS OF CHOLINESTERASE AND MEMANTINE INHIBITORS

Fruchtengarten, C., Ribeiro, L. M. V. R. E., Schichman, M. M., de Souza, B. P. B., de Sousa, D. M. A., Vieira, G. D. M., Arruda, D. F. D., Fernandes, L. F. E. V. D. M., Bárbara, J. P. S., GAISSLER, L. M., et al. (2023) · International Journal of Health Science · doi:10.22533/at.ed.15934123010610 · Cited by 1

Immunotherapy of Alzheimer’s Disease

Tondo, G., Marchi, F. D., Anselmi, M., & Comi, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_51 · Cited by 1

A Comparison of Representative Drugs Under Two Existing Treatment Strategies for Alzheimer's Disease

Zhong, Y. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2025.24223 · Cited by 1

Engineering a dimeric single-domain antibody for improved detection and neutralization of amyloid-β oligomers

Napolitano, L., Vadukul, D. M., Bigi, A., Palladino, P., Cecchi, C., Chiti, F., Cascella, R., & Aprile, F. A. (2026) · Communications Biology · doi:10.1038/s42003-026-09740-6 · Cited by 1

Anti-Amyloid-β Immunotherapy: A Leading Novel Avenue for Alzheimer's Disease

Babbar, R., Sharma, P., Sharma, T., Madaan, P., Arora, S., & Badavath, V. N. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220524090354 · Cited by 1

Agarwood (Aquilaria crassna) Inhibits Beta-amyloid and Tau-protein Formation in a Mouse Obesity Model

Jang, H.-M., Kim, J.-H., Park, G., Choi, Y. D., Kim, S.-E., & Jeon, G. J. (2022) · Journal of Animal Health and Production · doi:10.17582/journal.jahp/2022/10.2.221.225 · Cited by 1

阿尔茨海默症治疗的药物突破

Liu, Q. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0116

New Perspectives for Treatment in Alzheimer’s Disease

Loureiro, J. C., Silva, L. F. D. A. L. E., Pais, M. V., & Forlenza, O. V. (2022) · Springer eBooks · doi:10.1007/978-3-030-94383-7_10 · Cited by 1

Role of Phages in Past Molecular Biology and Potentially in Future Biomedicine

Serwer, P. (2025) · Encyclopedia · doi:10.3390/encyclopedia5020058 · Cited by 1

Drug development against dementia based on understanding of molecular and cellular pathogenesis

Tomita, T. (2019) · Drug Delivery System · doi:10.2745/dds.34.346

Integrated Genomic Analysis Highlights the Impaired PI3K-Akt Signaling Pathway in Alzheimer’s Disease

(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac122.23322339

Mast Cells and their Role in Health and Disease

Faustino, A., & Oliveira, P. A. (2022) · Nova Science Publishers eBooks · doi:10.52305/gpjw5150

From the Gut to the Brain and Back: Therapeutic Approaches for the Treatment of Network Dysfunction in Parkinson's Disease

Paolone, G. (2021) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pans.1.2021.25

Tetramethylpyrazine nitrone exerts neuroprotection via PGC-1α/Nrf2 activation and α-synuclein clearance in Parkinson’s disease modelsPreprint

Guo, B., Zheng, C., Cao, J., Li, S., Luo, F., Qiu, X., Zhang, K., Cai, W., Li, H., Wang, Y., et al. (2020) · doi:10.21203/rs.3.rs-32864/v1

Biomarkers in cerebrospinal fluid and blood aid diagnosis of dementia

Rosenberg, G. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823455-6.00001-8

Inhibition of miR-4763-3p expression in the brains of AD-MCI mice activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to reverse neuronal loss and ameliorate cognitive declinePreprint

Qi, W., Dong, N., Peiru, W. U., Fu, W., Liu, Q., Zhang, X., Wu, H., He, X., Wu, L., Ward, N., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4458094/v1

Pharmacotherapy of Alzheimer's disease: A thorny road to success

Ibrahim, N. H., Kumar, J., & Mohamed, W. M. Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00027-0

Clinical trials

Gregory, S., Saunders, S., & Ritchie, C. W. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-822240-9.00016-8

Electrochemical modulation of tau protein phosphorylation levels with biomimetic polyaniline membranes

Chien, S.-C., Chang, C., Wang, H.-J., Hsu, C., Wang, Y., Chuang, C., & Chen, J.-C. (2025) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2025.100805

The amyloid cascade hypothesis

Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00003-x

Engineering a Dimeric Single-Domain Antibody for Improved Detection and neutralization of Amyloid-β OligomersPreprint

Napolitano, L., Vadukul, D. M., Bigi, A., Cecchi, C., Chiti, F., Cascella, R., & Aprile, F. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.29.672921

Additional file 1 of A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

Bigi, A., Napolitano, L., Vadukul, D. M., Chiti, F., Cecchi, C., Aprile, F. A., & Cascella, R. (2024) · Figshare · doi:10.6084/m9.figshare.25025878

Additional file 2 of Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome

Maxwell, A. M., Yuan, P., Rivera, B. M., Schaaf, W., Mladinov, M., Prasher, V. P., Robinson, A., DeGrado, W. F., & Condello, C. (2021) · Figshare · doi:10.6084/m9.figshare.17696286

Additional file 1 of Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography

Rejc, L., Gómez-Vallejo, V., Joya, A., Arsequell, G., Egimendia, A., Castellnou, P., Ríos, X., Cossío, U., Baz, Z., Iglesias, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20033154

Additional file 2 of Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial

Wunderlich, G. R., Blahova, Z., Garcia, M., & Jessen, F. (2023) · Figshare · doi:10.6084/m9.figshare.22604207

Additional file 1 of Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome

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Additional file 1 of A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation

Prins, S., Zhuparris, A., Hart, E. P., Doll, R.-J., & Groeneveld, G. J. (2021) · Figshare · doi:10.6084/m9.figshare.15000164

Additional file 1 of Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer’s dementia: a randomized controlled trial

Wunderlich, G. R., Blahova, Z., Garcia, M., & Jessen, F. (2023) · Figshare · doi:10.6084/m9.figshare.22604204

Evaluation du canal calcique TRPA1 comme cible thérapeutique potentielle dans la pathogénèse de la maladie d’Alzheimer

Paumier, A. (2020) · theses.fr (ABES) · doi:10.70675/46cbb4bazf458z47a7z9fefzcdb3585ce4e9

D-sérine : un maillon central de la physiopathologie amyloïde ?

Ploux, E. (2022) · theses.fr (ABES) · doi:10.70675/e7b5bba0z9abcz4325zae71z841a60892f8b

Various Immunotherapy and Targeted Therapeutics for Managing Alzheimer’s Disease

Verma, M., & Singh, N. K. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898814953126010010

A narrative review on preclinical/clinical trials on aducanumab

Goel, A., Garima, G., Jain, P., Bansal, S., Chopra, H., Gupta, S., Kumar, S., Dhanawat, M., & Aggarwal, N. (2026) · Scripta Medica · doi:10.5937/scriptamed57-59386

Peptide vaccination for Alzheimer's disease: Immunological foundations, therapeutic potential, and translational barriers

Chen, H., Lin, Y. Y., Kang, D., & Zhao, T. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261462546

Second Section: A single domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.05

References

Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.references

Discussion

Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.07

Alzheimer’s immunotherapy: β-amyloid aggregates come unstuck

Martin, I. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aah7027

Anti-Aβ antibody treatment shows promise in Alzheimer disease

Fyfe, I. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.144 · Cited by 1

Beyond amyloid: New approaches to Alzheimer's disease treatment

(2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102648 · Cited by 3

Therapeutic news in Alzheimer’s disease: Soon a disease-modifying therapy?

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“Aducanumab” making a comeback in Alzheimer’s disease: An old wine in a new bottle

Behl, T., Kaur, I., Sehgal, A., Singh, S., Sharma, N., Makeen, H. A., Albratty, M., Alhazmi, H. A., Felemban, S. G., Alsubayiel, A. M., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112746 · Cited by 50