The challenges of anti-tau therapeutics in Alzheimer disease
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Recent clinical evidence indicates that antibodies targeting the microtubule-binding region (MTBR, residues 224 to 369) or phosphorylated epitopes around the center of tau are more likely to prevent the propagation of pathogenic aggregated tau.
“Recent clinical evidence indicates that antibodies targeting the microtubule-binding region (MTBR, residues 224 to 369) or phosphorylated epitopes around the center of tau are more likely to prevent the propagation of pathogenic aggregated tau [235, 236].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [236]
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References 7 · Cited by 23
- Authors
- Panza, F., & Lozupone, M.
- Affiliations
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- University of Bari Aldo Moro (IT)
- Corresponding author
- Panza, Francesco
- Venue
- Nature Reviews Neurology
- Published
- 2022-08-08
- Volume
- 18
- Issue
- 10
- Pages
- 577-578
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W4290723331
- Cited by
- 23
- References
- 7
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 4
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, tau antibodies, clinical benefit, therapeutic target, early Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Brain, Humans, Phosphorylation, tau Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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