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Cited by 248Motor Control and AdaptationTactile and Sensory InteractionsAction Observation and Synchronization

The neural mechanisms of manual dexterity

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Sobinov, Anton R., Bensmaia, Sliman J.·2021·Nature Reviews Neuroscience
DOI 10.1038/s41583-021-00528-7PMC PMC9169115
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Abstract

The hand endows us with unparalleled precision and versatility in our interactions with objects, from mundane activities such as grasping to extraordinary ones such as virtuoso pianism. The complex anatomy of the human hand combined with expansive and specialized neuronal control circuits allows a wide range of precise manual behaviours. To support these behaviours, an exquisite sensory apparatus, spanning the modalities of touch and proprioception, conveys detailed and timely information about our interactions with objects and about the objects themselves. The study of manual dexterity provides a unique lens into the sensorimotor mechanisms that endow the nervous system with the ability to flexibly generate complex behaviour.

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  • Childhood epileptic encephalopathy presents psychomotor alterations with dysfunctions in postural control, tremors, involuntary muscle coordination, motor control problems, and cognitive alterations.

    “Childhood EE presents psychomotor alterations with dysfunctions in postural control, tremors, involuntary muscle coordination, motor control problems, and cognitive alterations [17].”

    From Serious Game for Fine Motor Control Rehabilitation for Children With Epileptic Encephalopathy: Development and Usability Study (2023) · cites this paper as [17]

    The section “Hand control signals in the cortex” discusses motor deficits after motor-cortex lesions, not childhood epileptic encephalopathy. Searches for childhood epileptic encephalopathy and the listed psychomotor symptoms found no passage in our copy addressing that condition; page numbers were not provided. (LLM, conf=0.76)

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Authors
Sobinov, A. R., & Bensmaia, S. J.
Affiliations
University of Chicago (US)
ORCID
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2021-10-28
Volume
22
Issue
12
Pages
741-757
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/s41583-021-00528-7
PMC
PMC9169115
OpenAlex
W3209025803
Cited by
248
References
445
Citations by year
2026: 40 · 2025: 79 · 2024: 64 · 2023: 38 · 2022: 26 · 2021: 1
FWCI
4.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (UH3NS107714, R35NS122333)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Keywords
manual dexterity, hand motor control, grasping, sensorimotor integration, touch, proprioception, motor control circuit, hand anatomy
MeSH terms
Hand, Humans, Motor Skills, Proprioception, Touch Perception

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