Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
Open accessAbstract
In the originally published version of this Letter, ref. 43 was erroneously provided twice. In the 'Estimation of relative cell-type-specific composition of AML samples' section in the Methods, the citation to ref. 43 after the GEO dataset GSE24759 is correct. However, in the 'Mice' section of the Methods, the citation to ref. 43 after 'TAMERE' should have been associated with a new reference1. The original Letter has been corrected online (with the new reference included as ref. 49).
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At least a few enhancers reside at great distances from their target gene (e.g. ZRS 1 Mb from Shh, MYC enhancer 1.7 Mb downstream), although most are much more proximal.
“At least a few enhancers reside at great distances from their target gene (e.g. the ZRS enhancer located 1 Mb from the Shh gene118, and a MYC enhancer located 1.7 Mb downstream119), although most are much more proximal to their target promoters72.”
From Towards a comprehensive catalogue of validated and target-linked human enhancers (2020) · cites this paper as [119]
The cited source is an Author Correction (Nature 558, E4). Its correction notice discusses a duplicated reference, not the location of a MYC enhancer. Searches for “MYC enhancer located 1.7 Mb downstream” and “1.7 Mb downstream of Myc enhancer” found no passage in our copy addressing that distance. (LLM, conf=0.78)
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“However, there are some examples of interactions between CREs and genes separated by large distances, such as enhancers of the MYC gene located almost 2 Mb downstream of it 164 .”
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“For example, the elements within the Myc and alpha-globin super-enhancers appear to combine their effects in an additive fashion [137, 138].”
Yu, G.-P., Zhang, W., Basyal, M., Nishida, Y., Mizumo, H., Ly, C., Zhang, H., Rice, W. G., & Andreeff, M. (2024) · Leukemia and Lymphoma · doi:10.1080/10428194.2024.2364839 · Cited by 5 · see citing works
- Authors
- Bahr, C., von Paleske, L., Uslu, V. V., Remeseiro, S., Takayama, N., Ng, S. W., Murison, A., Langenfeld, K., Petretich, M., Scognamiglio, R., Zeisberger, P., Benk, A. S., Amit, I., Zandstra, P. W., Lupien, M., Dick, J. E., Trumpp, A., & Spitz, F.
- Affiliations
- German Cancer Research Center (DE)
- European Molecular Biology Laboratory (DE)
- University Health Network (CA)
- University of Toronto (CA)
- Weizmann Institute of Science (IL)
- University of British Columbia (CA)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Trumpp, Andreas
- ORCID
- Venue
- Nature
- Published
- 2018-05-16
- Volume
- 558
- Issue
- 7711
- Pages
- E4-E4
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2800548555
- Cited by
- 11
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 3 · 2019: 1 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- hematopoietic stem cells, leukemia, acute myeloid leukemia, stem cell hierarchy
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