The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus
Open accessAbstract
Intestinal commensal bacteria can inhibit dense colonization of the gut by vancomycin-resistant Enterococcus faecium (VRE), a leading cause of hospital-acquired infections1,2. A four-strained consortium of commensal bacteria that contains Blautia producta BPSCSK can reverse antibiotic-induced susceptibility to VRE infection3. Here we show that BPSCSK reduces growth of VRE by secreting a lantibiotic that is similar to the nisin-A produced by Lactococcus lactis. Although the growth of VRE is inhibited by BPSCSK and L. lactis in vitro, only BPSCSK colonizes the colon and reduces VRE density in vivo. In comparison to nisin-A, the BPSCSK lantibiotic has reduced activity against intestinal commensal bacteria. In patients at high risk of VRE infection, high abundance of the lantibiotic gene is associated with reduced density of E. faecium. In germ-free mice transplanted with patient-derived faeces, resistance to VRE colonization correlates with abundance of the lantibiotic gene. Lantibiotic-producing commensal strains of the gastrointestinal tract reduce colonization by VRE and represent potential probiotic agents to re-establish resistance to VRE. The gut commensal Blautia producta secretes a lantibiotic that reduces colonization of the gut by the major pathogen vancomycin-resistant Enterococcus faecium, and transplantation of microbiota with high abundance of the lantibiotic gene enhances resistance to colonization in mice.
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Liu, X., Mao, B., Gu, J., Wu, J., Cui, S., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1875796 · Cited by 1,381
New developments in RiPP discovery, enzymology and engineering
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Microbiota-mediated colonization resistance: mechanisms and regulation
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Metadata
- Authors
- Kim, S. G., Becattini, S., Moody, T. U., Shliaha, P. V., Littmann, E. R., Seok, R., Gjonbalaj, M., Eaton, V., Fontana, E., Amoretti, L., Wright, R., Caballero, S., Wang, Z.-M. X., Jung, H.-J., Morjaria, S. M., Leiner, I. M., Qin, W., Ramos, R. J. J. F., Cross, J. R., Narushima, S., Honda, K., Peled, J. U., Hendrickson, R. C., Taur, Y., van den Brink, M. R. M., & Pamer, E. G.
- Venue
- Nature
- Published
- 2019-08-21
- Volume
- 572
- Issue
- 7771
- Pages
- 665-669
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2969673299
- Cited by
- 283
- References
- 41
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, S. G., Becattini, S., Moody, T. U., Shliaha, P. V., Littmann, E. R., Seok, R., Gjonbalaj, M., Eaton, V., Fontana, E., Amoretti, L., Wright, R., Caballero, S., Wang, Z.-M. X., Jung, H.-J., Morjaria, S. M., Leiner, I. M., Qin, W., Ramos, R. J. J. F., Cross, J. R., . . . Pamer, E. G. (2019). Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Nature. https://doi.org/10.1038/s41586-019-1501-z
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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