The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Creatine kinase B controls futile creatine cycling in thermogenic fat
Open accessAbstract
Obesity increases the risk of mortality because of metabolic sequelae such as type 2 diabetes and cardiovascular disease1. Thermogenesis by adipocytes can counteract obesity and metabolic diseases2,3. In thermogenic fat, creatine liberates a molar excess of mitochondrial ADP—purportedly via a phosphorylation cycle4—to drive thermogenic respiration. However, the proteins that control this futile creatine cycle are unknown. Here we show that creatine kinase B (CKB) is indispensable for thermogenesis resulting from the futile creatine cycle, during which it traffics to mitochondria using an internal mitochondrial targeting sequence. CKB is powerfully induced by thermogenic stimuli in both mouse and human adipocytes. Adipocyte-selective inactivation of Ckb in mice diminishes thermogenic capacity, increases predisposition to obesity, and disrupts glucose homeostasis. CKB is therefore a key effector of the futile creatine cycle. Upon induction by thermogenic stimuli, creatine kinase B traffics to mitochondria to trigger the futile creatine cycle in thermogenic fat.
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Cites
Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity
Ward, Z. J., Bleich, S. N., Cradock, A. L., Barrett, J. L., Giles, C. M., Flax, C., Long, M. W., & Gortmaker, S. L. (2019) · New England Journal of Medicine · doi:10.1056/nejmsa1909301 · Cited by 2,009
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075
A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
Challa, T. D., Dapito, D. H., Kulenkampff, E., Kiehlmann, E., Moser, C., Straub, L., Sun, W., & Wolfrum, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.055 · Cited by 42
Cited by
Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review
Bonilla, D. A., Kreider, R. B., Stout, J. R., Forero, D. A., Kerksick, C. M., Roberts, M. D., & Rawson, E. S. (2021) · Nutrients · doi:10.3390/nu13041238 · Cited by 223
Adipose Tissue and Metabolic Health
An, S.-M., Cho, S.-H., & Yoon, J. C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0011 · Cited by 184
Hammoud, S. H., AlZaim, I., Al-Dhaheri, Y., Eid, A. H., & El-Yazbi, A. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.707126 · Cited by 87
Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis
Park, I., Kim, K.-E., Kim, J., Kim, A.-K., Bae, S., Jung, M., Choi, J., Mishra, P. K., Kim, T.-M., Kwak, C., et al. (2024) · Nature Chemical Biology · doi:10.1038/s41589-023-01452-w · Cited by 39
Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic
Zekri, Y., Flamant, F., & Gauthier, K. (2021) · Cells · doi:10.3390/cells10061327 · Cited by 27
Metadata
- Authors
- Rahbani, J. F., Roesler, A., Hussain, M. F., Samborska, B., Dykstra, C. B., Tsai, L., Jedrychowski, M. P., Vergnes, L., Reue, K., Spiegelman, B. M., & Kazak, L.
- Venue
- Nature
- Published
- 2021-02-17
- Volume
- 590
- Issue
- 7846
- Pages
- 480-485
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3131597949
- Cited by
- 205
- References
- 4
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Rahbani, J. F., Roesler, A., Hussain, M. F., Samborska, B., Dykstra, C. B., Tsai, L., Jedrychowski, M. P., Vergnes, L., Reue, K., Spiegelman, B. M., & Kazak, L. (2021). Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature. https://doi.org/10.1038/s41586-021-03221-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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