Ptbp1 deletion does not induce astrocyte-to-neuron conversion
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Some reported conversions reflected viral promoter leakage into pre-existing neurons.
“However, subsequent lineage-tracing studies yielded conflicting results, suggesting that PTBP1 depletion alone may be insufficient to drive genuine astrocyte-to-neuron conversion in the adult mammalian brain, raising concerns that some reported conversions reflected viral promoter leakage into pre-existing neurons.”
From Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration (2026) · cites this paper as [18]
Subsequent lineage-tracing studies yielded conflicting results, suggesting that PTBP1 depletion alone may be insufficient to drive genuine astrocyte-to-neuron conversion in the adult mammalian brain.
“However, subsequent lineage-tracing studies yielded conflicting results, suggesting that PTBP1 depletion alone may be insufficient to drive genuine astrocyte-to-neuron conversion in the adult mammalian brain, raising concerns that some reported conversions reflected viral promoter leakage into pre-existing neurons.”
From Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration (2026) · cites this paper as [18]
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Cites
Srinivasan, R., Lu, T.-Y., Chai, H., Xu, J., Huang, B. S., Golshani, P., Coppola, G., & Khakh, B. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.030 · Cited by 443 · see citing works
Revisiting astrocyte to neuron conversion with lineage tracing in vivo
Wang, L.-L., Serrano, C., Zhong, X., Ma, S., Zou, Y., & Zhang, C.-L. (2021) · Cell · doi:10.1016/j.cell.2021.09.005 · Cited by 329 · see citing works
Chen, W., Zheng, Q., Huang, Q., Ma, S., & Li, M. (2022) · eLife · doi:10.7554/elife.75636 · Cited by 89 · see citing works
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Research works printed but not linked: 10
- [1]Qian H Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582, 550– 556 (2020). 32581380 PMC7521455
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- [11]Wang L-L & Zhang C-L Therapeutic potential of PTBP1 inhibition, if any, is not attributed to glia-to-neuron conversion. Annu. Rev. Neurosci. 10.1146/annurev-neuro-092822-083410 (2022). PMC10404630 36750409 · DOI
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Cited by
Sorted by citations
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
Wang, M., VanderVeen, B., Xu, Z. A., Xu, Y., Mintzer, J., Murphy, A., Zhang, Q., & Xu, P. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100575
- Authors
- Hoang, T., Kim, D. W., Appel, H., Ozawa, M., Zheng, S., Kim, J., & Blackshaw, S.
- Affiliations
- Johns Hopkins University (US)
- The University of Tokyo (JP)
- University of California, Riverside (US)
- Corresponding author
- Hoang, Thanh
- Kim, Dong Won
- Blackshaw, Seth
- Venue
- Nature
- Published
- 2023-06-07
- Volume
- 618
- Issue
- 7964
- Pages
- E1-E7
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC12327411
- OpenAlex
- W4379654057
- Cited by
- 60
- References
- 3
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 18 · 2023: 11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Research to Prevent Blindness
- Johns Hopkins University
- Maryland Stem Cell Research Fund (2019-MSCRFF-5124)
- National Institutes of Health
- Japan Society for the Promotion of Science (23K27084, 20H03162)
- National Eye Institute (R01EY020560, R01EY031685, U01EY027267, R24EY027283, R01EY036173)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- PTBP1, polypyrimidine tract-binding protein, astrocyte-to-neuron conversion, neuronal reprogramming, Parkinson's disease, glial fibrillary acidic protein, neuronal identity, transposable elements, retrotransposons, retroviral vectors, adeno-associated virus vectors, transgenic mouse model, neuronal heterogeneity
- MeSH terms
- Astrocytes, Humans, Neurons, Parkinson Disease
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