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Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients
Open accessAbstract
Autologous induced pluripotent stem cells (iPSCs) constitute an unlimited cell source for patient-specific cell-based organ repair strategies. However, their generation and subsequent differentiation into specific cells or tissues entail cell line-specific manufacturing challenges and form a lengthy process that precludes acute treatment modalities. These shortcomings could be overcome by using prefabricated allogeneic cell or tissue products, but the vigorous immune response against histo-incompatible cells has prevented the successful implementation of this approach. Here we show that both mouse and human iPSCs lose their immunogenicity when major histocompatibility complex (MHC) class I and II genes are inactivated and CD47 is over-expressed. These hypoimmunogenic iPSCs retain their pluripotent stem cell potential and differentiation capacity. Endothelial cells, smooth muscle cells, and cardiomyocytes derived from hypoimmunogenic mouse or human iPSCs reliably evade immune rejection in fully MHC-mismatched allogeneic recipients and survive long-term without the use of immunosuppression. These findings suggest that hypoimmunogenic cell grafts can be engineered for universal transplantation.
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“These gene-edited iPSCs could differentiate into endothelial cells and cardiomyocytes that demonstrated long-term survival in humanized mouse models without any immunosuppression.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [118]
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“Overexpression of CD47 has also been successfully implemented to mitigate innate immune responses after HLA deletion.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [118]
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Cites
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578
Humanized mice in translational biomedical research
Shultz, L. D., Ishikawa, F., & Greiner, D. L. (2007) · Nature reviews. Immunology · doi:10.1038/nri2017 · Cited by 1,393
Humanized mice in translational biomedical research
Shultz, L. (2007) · The Mouseion at the JAXlibrary (Jackson Laboratory) · Cited by 1,036
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Shiba, Y., Gomibuchi, T., Seto, T., Wada, Y., Ichimura, H., Tanaka, Y., Ogasawara, T., Okada, K., Shiba, N., Sakamoto, K., et al. (2016) · Nature · doi:10.1038/nature19815 · Cited by 840
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1
Melkus, M. W., Estes, J. D., Padgett‐Thomas, A., Gatlin, J., Denton, P. W., Othieno, F. A., Wege, A. K., Haase, A. T., & Garcia, J. V. (2006) · Nature Medicine · doi:10.1038/nm1431 · Cited by 653
Self-citationHLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells
Gornalusse, G. G., Hirata, R. K., Funk, S. E., Riolobos, L., Lopes, V. S., Manske, G., Prunkard, D., Colunga, A. G., Hanafi, L.-A., Clegg, D. O., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3860 · Cited by 639
Fetomaternal immune cross-talk and its consequences for maternal and offspring's health
Arck, P., & Hecher, K. (2013) · Nature Medicine · doi:10.1038/nm.3160 · Cited by 609
Wunderlich, M., Chou, F.-S., Link, K. A., Mizukawa, B., Perry, R. L., Carroll, M., & Mulloy, J. C. (2010) · Leukemia · doi:10.1038/leu.2010.158 · Cited by 415
Chang, C., Fontes, J., Peterlin, M., & Flavell, R. (1994) · Journal of Experimental Medicine · doi:10.1084/jem.180.4.1367 · Cited by 352
Gyöngyösi, M., Wojakowski, W., Lemarchand, P., Lunde, K., Tendera, M., Bartunek, J., Marbán, E., Aßmus, B., Henry, T. D., Traverse, J. H., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.304346 · Cited by 313
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Verhoeff, K. K., Marfil‐Garza, B. A., Cuesta‐Gomez, N., Jasra, I. T., Dadheech, N., & Shapiro, A. M. J. (2022) · Advances in experimental medicine and biology · doi:10.1007/5584_2022_711 · Cited by 1
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Goulart, E. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2716-7_9 · Cited by 1
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Kimura, T., & Muguruma, K. (2022) · Folia Pharmacologica Japonica · doi:10.1254/fpj.22084 · Cited by 1
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Zubarev, I. V., Podenkova, U. I., Tomilin, A. N., & Цимоха, А. С. (2022) · Russian Journal of Developmental Biology · doi:10.1134/s1062360422060091 · Cited by 1
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Borrego, A. B., & Gill, S. I. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-02013-1 · Cited by 1
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Verhoeff, K. K., & Shapiro, A. M. J. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_18 · Cited by 1
Ashmore‐Harris, C., Ayabe, H., Yoshizawa, E., Arisawa, T., Takada, Y., Takebe, T., & Fruhwirth, G. O. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101406 · Cited by 1
Miranda-Nieves, D., Ashour, A., & Chaikof, E. L. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-030-44211-8_15 · Cited by 1
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Barra, J. M., & Russ, H. A. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001444 · Cited by 1
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Zhao, F., Sharma, D., Sharma, A., Hu, L., Chen, T.-A., Voon, S., Bayless, K. J., Goldman, J., & Walsh, A. J. (2022) · Research Square · doi:10.21203/rs.3.rs-2325499/v1 · Cited by 1
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Berndt, R. (2022) · Wiener klinisches Magazin · doi:10.1007/s00740-022-00443-2
Truskey, G. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737220683.793570184
Khalid, M., Patel, H., Syed, S., & Lakhi, S. (2022) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.303
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Verhoeff, K. K., & Shapiro, A. M. J. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_18-1
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Crane, A., Müller, Y. D., Bromberg, J. S., & Meier, R. P. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23571-9.00048-7
Glaser, V., Flugel, C., Kath, J., Du, W., Drosdek, V., Franke, C., Stein, M., Prüß, A., Schmueck‐Henneresse, M., Volk, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688654
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Teo, A. K. S., Tan, K. S. M., Koh, Y. X., Koh, A., & Teo, A. K. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00143-5
Dongsar, T. T., Bajaj, K., Dongsar, T. S., Ali, A., Hasan, N., & Ahmad, F. J. (2025) · Current Cancer Drug Targets · doi:10.2174/0115680096349248250113093025
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Self-citationZhang, N., Yang, Y., Chen, M.-Q., Zou, Q., Quan, L.-Q., Huang, J., Zhang, Q.-J., Zhao, Y., Ouyang, Z., Zhang, Z., et al. (2025) · bioRxiv · doi:10.1101/2025.09.03.673895
Naumovas, D., Rojas-Araya, B., Polanco, C. M., Andrade, V., Čekauskienė, R., Valatkaite-Rakstiene, B., Laurinaitytė, I., Jakubauskas, A., Stoškus, M., Griškevičius, L., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626787
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Generoso, S., Levovitz, S., Jaramillo, S., Kim, M., Dara, S., Phen, S. F., Yi, B., Yanagi, T., DesMarais, T. L., Agmon, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.16.676382 · Cited by 1
Andriianov, V. S., Malyutina, A., Panferov, E., Karabelsky, A. V., Ivanov, R. A., Minskaia, E., & Reshetnikov, V. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199432
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Zhuang, Z., Liu, Z., Su, H., Sun, W., Zhu, Q., Xu, J., Fang, J., Li, L., Shen, D., Zou, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.12.693855
Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12756787
Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12756796
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Sawula, E., Miersch, S., Jong, E. D., Li, C., Chou, F.-Y., Tang, J. K., Saberianfar, R., Harding, J., Sidhu, S. S., & Nagy, A. (2024) · Figshare · doi:10.6084/m9.figshare.26636607
Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12756790
Tsuneyoshi, N., Hosoya, T., Takeno, Y., Saitoh, K., Murai, H., Amimoto, N., Tatsumi, R., Watanabe, S., Hasegawa, Y., Kikkawa, E. F., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26741663
Bogomiakova, M. E., Sekretova, E. K., Anufrieva, K. S., Khabarova, P. O., Kazakova, A. N., Bobrovsky, P. A., Grigoryeva, T. V., Eremeev, A., Lebedeva, O. S., Bogomazova, A. N., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22624430
Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12756793
Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12756784
Ru, L., Wu, N., Wei, K., Zeng, Y., Li, Q., Weng, C., Ren, C., Ren, B., Huo, D., Li, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13290500
Self-citationAndrade da Silva, L. H., Heuer, R. A., Roque, C. B., McGuire, T. L., Hosoya, T., Kimura, H., Tamura, K., & Matsuoka, A. J. (2023) · Figshare · doi:10.6084/m9.figshare.22623832
Chen, Y., Zhou, Y., Zhou, Z., Fang, Y., Ma, L., Zhang, X., Xiong, J., & Liu, L. (2023) · Figshare · doi:10.6084/m9.figshare.22609745
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Metadata
- Authors
- Deuse, T., Hu, X., Gravina, A., Wang, D., Tediashvili, G., De, C., Thayer, W. O., Wahl, A., Garcia, J. V., Reichenspurner, H., Davis, M. M., Lanier, L. L., & Schrepfer, S.
- Affiliations
- University of California, San Francisco (US)
- Universität Hamburg (DE)
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Schrepfer, Sonja
- ORCID
- Venue
- Nature Biotechnology
- Published
- 2019-02-18
- Volume
- 37
- Issue
- 3
- Pages
- 252-258
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- PMC
- PMC6419516
- OpenAlex
- W2911604931
- Cited by
- 758
- References
- 31
- Citations by year
- 2026: 98 · 2025: 102 · 2024: 102 · 2023: 113 · 2022: 94 · 2021: 97 · 2020: 106 · 2019: 46
- FWCI
- 28.36
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-09-16)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL140236)
- National Institute of Mental Health (R01MH108179)
- National Institute of Allergy and Infectious Diseases (R01AI068129, R01AI111899, R01AI123010, U19AI057229)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- induced pluripotent stem cells, immune rejection, allogeneic transplantation, MHC mismatch, endothelial cells, smooth muscle cells, cardiomyocytes, immunosuppression-free transplantation
- MeSH terms
- Animals, Cell Differentiation, Graft Rejection, HLA Antigens, Humans, Transplantation, Homologous, Histocompatibility Antigens Class I, Myocytes, Cardiac, Mice, Induced Pluripotent Stem Cells
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