The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
Open accessAbstract
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics-based test for independent mutations. In addition to mutations in established and recently described resistance-associated genes, novel mutations were discovered for resistance to cycloserine, ethionamide and para-aminosalicylic acid. The capacity to detect mutations associated with resistance to ethionamide, pyrazinamide, capreomycin, cycloserine and para-aminosalicylic acid was enhanced by inclusion of insertions and deletions. Odds ratios for mutations within candidate genes were found to reflect levels of resistance. New epistatic relationships between candidate drug-resistance-associated genes were identified. Findings also suggest the involvement of efflux pumps (drrA and Rv2688c) in the emergence of resistance. This study will inform the design of new diagnostic tests and expedite the investigation of resistance and compensatory epistatic mechanisms. A GWAS of multi- and extensively drug-resistant tuberculosis using 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries identifies novel mutations associated with resistance. The capacity to detect resistance in particular to ethionamide, pyrazinamide, capreomycin, cycloserine and paraaminosalicylic acid was enhanced by inclusion of insertions and deletions.
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The Sequence Alignment/Map format and SAMtools
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Genome-wide efficient mixed-model analysis for association studies
Zhou, X., & Stephens, M. (2012) · Nature Genetics · doi:10.1038/ng.2310 · Cited by 3,627
inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis
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The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
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Cited by
Phelan, J. E., O’Sullivan, D. M., Machado, D., Ramos, J., Oppong, Y. E. A., Campino, S., O’Grady, J., McNerney, R., Hibberd, M. L., Viveiros, M., et al. (2019) · Genome Medicine · doi:10.1186/s13073-019-0650-x · Cited by 518
Self-citationTuberculosis: advances and challenges in development of new diagnostics and biomarkers
Walzl, G., McNerney, R., du Plessis, N., Bates, M., McHugh, T. D., Chegou, N. N., & Zumla, A. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30111-7 · Cited by 341
Self-citationOtwinowska, A., Koszucki, J., Panicker, V. R., Leconte, J., Olejniczak, S., Holt, K. E., Feil, E. J., Rocha, E. P. C., Smug, B., Maciejewska, B., et al. (2026) · PLOS Biology · doi:10.1371/journal.pbio.3003716 · Cited by 5
Metadata
- Authors
- Coll, F., Phelan, J., Hill-Cawthorne, G. A., Nair, M. B., Mallard, K., Ali, S., Abdallah, A. M., Alghamdi, S., Alsomali, M., Ahmed, A. O., Portelli, S., Oppong, Y., Alves, A., Bessa, T. B., Campino, S., Caws, M., Chatterjee, A., Crampin, A. C., Dheda, K., Furnham, N., Glynn, J. R., Grandjean, L., Minh Ha, D., Hasan, R., Hasan, Z., Hibberd, M. L., Joloba, M., Jones-López, E. C., Matsumoto, T., Miranda, A., Moore, D. J., Mocillo, N., Panaiotov, S., Parkhill, J., Penha, C., Perdigão, J., Portugal, I., Rchiad, Z., Robledo, J., Sheen, P., Shesha, N. T., Sirgel, F. A., Sola, C., Oliveira Sousa, E., Streicher, E. M., Helden, P. V., Viveiros, M., Warren, R. M., McNerney, R., Pain, A., & Clark, T. G.
- Venue
- Nature Genetics
- Published
- 2018-01-22
- Volume
- 50
- Issue
- 2
- Pages
- 307-316
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2783758534
- Cited by
- 375
- References
- 6
- FWCI
- 29.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Coll, F., Phelan, J., Hill-Cawthorne, G. A., Nair, M. B., Mallard, K., Ali, S., Abdallah, A. M., Alghamdi, S., Alsomali, M., Ahmed, A. O., Portelli, S., Oppong, Y., Alves, A., Bessa, T. B., Campino, S., Caws, M., Chatterjee, A., Crampin, A. C., Dheda, K., . . . Clark, T. G. (2018). Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Nature Genetics. https://doi.org/10.1038/s41588-017-0029-0
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