Prospecting for molecular glues
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Unlike PROTACs, molecular glues possess a dual-ligand structure for both E3 ubiquitin ligase and target proteins, enabling ubiquitination and degradation of previously undruggable targets and PPIs.
“Unlike PROTACs, molecular glues possess a dual-ligand structure for both E3 ubiquitin ligase and target proteins, enabling the ubiquitination and degradation of previously undruggable targets and PPIs.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [523]
Molecular glues are small molecules that promote interaction between E3 ubiquitin ligase, substrate receptors, and target proteins, leading to ubiquitination and degradation by the proteasome.
“Molecular glues are a class of small molecules that promote interaction between E3 ubiquitin ligase, substrate receptors, and target proteins, leading to ubiquitination and degradation by the proteasome.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [523]
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References 6 · Cited by 55
- Authors
- den Besten, W., & Lipford, J. R.
- Affiliations
- Amgen (United States) (US)
- Corresponding author
- Lipford, J. Russell
- Venue
- Nature Chemical Biology
- Published
- 2020-08-03
- Volume
- 16
- Issue
- 11
- Pages
- 1157-1158
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W3046680580
- Semantic Scholar
- f1f211b9f5af325986dfe634b529fd4d3d526b6e
- Cited by
- 55
- References
- 6
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 17 · 2021: 10
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- molecular glues, CDK12 inhibitors, protein degradation, ubiquitination, small molecule inhibitors
- MeSH terms
- Cyclins
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