CD4+ T cell memory
Open accessAbstract
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II-peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect the tissues from reinfection and cancer, but also participate in allergy, autoimmunity, graft rejection and chronic inflammation. Here we provide updates on our understanding of the longevity, functional heterogeneity, differentiation, plasticity, migration and human immunodeficiency virus reservoirs as well as key technological advances that are facilitating the characterization of memory CD4+ T cell biology.
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References 180 · Cited by 338
- Authors
- Künzli, M., & Masopust, D.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Masopust, David
- Venue
- Nature Immunology
- Published
- 2023-05-08
- Volume
- 24
- Issue
- 6
- Pages
- 903-914
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC10343737
- OpenAlex
- W4375859102
- Cited by
- 338
- References
- 180
- Citations by year
- 2026: 91 · 2025: 131 · 2024: 100 · 2023: 16
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health (R01CA238439, R01AI146032, R01AI084913, R01AI150600)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (P2B-SP3-200187)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory CD4+ T cells, T cell differentiation, T cell plasticity, T cell migration, HIV reservoir, T cell longevity, functional heterogeneity, peptide-MHC class II complexes, B cell help, tissue homeostasis, immune regulation, allergy, autoimmunity, graft rejection, chronic inflammation
- MeSH terms
- Memory T Cells, Humans, Immunologic Memory, CD4-Positive T-Lymphocytes
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