The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
Open accessAbstract
Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical models. Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response. In multiple mouse models, we show that liver metastases siphon activated CD8+ T cells from systemic circulation. Within the liver, activated antigen-specific Fas+CD8+ T cells undergo apoptosis following their interaction with FasL+CD11b+F4/80+ monocyte-derived macrophages. Consequently, liver metastases create a systemic immune desert in preclinical models. Similarly, patients with liver metastases have reduced peripheral T cell numbers and diminished tumoral T cell diversity and function. In preclinical models, liver-directed radiotherapy eliminates immunosuppressive hepatic macrophages, increases hepatic T cell survival and reduces hepatic siphoning of T cells. Thus, liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T cell deletion, and the combination of liver-directed radiotherapy and immunotherapy could promote systemic antitumor immunity. Liver metastases reduce clinical and preclinical immune-checkpoint inhibitor efficacy through hepatic siphoning of circulating activated CD8+ T cells, but therapeutic benefit can be improved by combining immunotherapy with liver-directed radiotherapy.
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Metadata
- Authors
- Yu, J., Green, M. D., Li, S., Sun, Y., Journey, S. N., Choi, J. E., Rizvi, S. M., Qin, A., Waninger, J. J., Lang, X., Chopra, Z., El Naqa, I., Zhou, J., Bian, Y., Jiang, L., Tezel, A., Skvarce, J., Achar, R. K., Sitto, M., Rosen, B. S., Su, F., Narayanan, S. P., Cao, X., Wei, S., Szeliga, W., Vatan, L., Mayo, C., Morgan, M. A., Schonewolf, C. A., Cuneo, K., Kryczek, I., Ma, V. T., Lao, C. D., Lawrence, T. S., Ramnath, N., Wen, F., Chinnaiyan, A. M., Cieslik, M., Alva, A., & Zou, W.
- Venue
- Nature Medicine
- Published
- 2021-01
- Volume
- 27
- Issue
- 1
- Pages
- 152-164
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3119086885
- Cited by
- 1,001
- References
- 19
- FWCI
- 51.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, J., Green, M. D., Li, S., Sun, Y., Journey, S. N., Choi, J. E., Rizvi, S. M., Qin, A., Waninger, J. J., Lang, X., Chopra, Z., El Naqa, I., Zhou, J., Bian, Y., Jiang, L., Tezel, A., Skvarce, J., Achar, R. K., Sitto, M., . . . Zou, W. (2021). Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nature Medicine. https://doi.org/10.1038/s41591-020-1131-x
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