The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
SAVER: gene expression recovery for single-cell RNA sequencing
Open accessPublished version of a preprint
Abstract
In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts present in each cell are sequenced. This leads to unreliable quantification of genes with low or moderate expression, which hinders downstream analysis. To address this challenge, we developed SAVER (single-cell analysis via expression recovery), an expression recovery method for unique molecule index (UMI)-based scRNA-seq data that borrows information across genes and cells to provide accurate expression estimates for all genes. SAVER accurately recovers expression values in single-cell RNA-sequencing data to improve downstream analysis.
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Cited by
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Metadata
- Authors
- Huang, M., Wang, J., Torre, E., Dueck, H., Shaffer, S., Bonasio, R., Murray, J. I., Raj, A., Li, M., & Zhang, N. R.
- Venue
- Nature Methods
- Published
- 2018-06-25
- Volume
- 15
- Issue
- 7
- Pages
- 539-542
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2951217100
- Cited by
- 747
- References
- 27
- FWCI
- 23.86
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
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- Huang, M., Wang, J., Torre, E., Dueck, H., Shaffer, S., Bonasio, R., Murray, J. I., Raj, A., Li, M., & Zhang, N. R. (2018). SAVER: gene expression recovery for single-cell RNA sequencing. Nature Methods. https://doi.org/10.1038/s41592-018-0033-z
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