Animal models in SARS-CoV-2 research

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W.-C., Uhl, S., Hoagland, D., Møller, R., Jordan, T. X., Oishi, K., Panis, M., Sachs, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.026 · Cited by 4,222

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sia, S. F., Yan, L.-M., Chin, A. W. H., Fung, K., Choy, K.-T., Wong, A. Y. L., Kaewpreedee, P., Perera, R. A. P. M., Poon, L. L. M., Nicholls, J. M., et al. (2020) · Nature · doi:10.1038/s41586-020-2342-5 · Cited by 1,342

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Baum, A., Fulton, B. O., Wloga, E., Copin, R., Pascal, K. E., Russo, V., Giordano, S., Lanza, K., Negron, N., Ni, M., et al. (2020) · Science · doi:10.1126/science.abd0831 · Cited by 1,253

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Hansen, J., Baum, A., Pascal, K. E., Russo, V., Giordano, S., Wloga, E., Fulton, B. O., Yan, Y., Koon, K., Patel, K., et al. (2020) · Science · doi:10.1126/science.abd0827 · Cited by 1,210

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Bao, L., Deng, W., Huang, B., Gao, H., Liu, J., Ren, L., Wei, Q., Yu, P., Xu, Y., Qi, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2312-y · Cited by 1,126

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Chan, J. F., Zhang, J., Yuan, S., Poon, V. K., Chan, C. C., Lee, A. C.-Y., Chan, W.-M., Fan, Z., Tsoi, H.-W., Wen, L., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa325 · Cited by 1,048

Lethal Infection of K18- hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus

McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., et al. (2007) · Journal of Virology · doi:10.1128/jvi.02012-06 · Cited by 1,010

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Imai, M., Iwatsuki‐Horimoto, K., Hatta, M., Loeber, S. J., Halfmann, P., Nakajima, N., Watanabe, T., Ujie, M., Takahashi, K., Ito, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009799117 · Cited by 994

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Winkler, E. S., Bailey, A. L., Kafai, N. M., Nair, S., McCune, B. T., Yu, J., Fox, J. M., Chen, R. E., Earnest, J. T., Keeler, S. P., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0778-2 · Cited by 901

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Kim, Y., Kim, S.-G., Kim, S.-M., Kim, E.-H., Park, S.-J., Yu, K.-M., Chang, J.-H., Kim, E. J., Lee, S., Casel, M. A. B., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.023 · Cited by 883

Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452

Accelerating antiviral drug discovery: lessons from COVID-19

von Delft, A., Hall, M. D., Kwong, A. D., Purcell, L. A., Saikatendu, K. S., Schmitz, U., Tallarico, J. A., & Lee, A. A. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00692-8 · Cited by 230

SARS-CoV-2 biology and host interactions

Steiner, S., Kratzel, A., Barut, G. T., Lang, R. M., Moreira, É. A., Thomann, L., Kelly, J. N., & Thiel, V. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-01003-z · Cited by 235

The Role of Viral Infections in the Onset of Autoimmune Diseases

Sundaresan, B., Shirafkan, F., Ripperger, K., & Rattay, K. (2023) · Viruses · doi:10.3390/v15030782 · Cited by 204

COVID-19, Myocarditis and Pericarditis

Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 194

Animal models for COVID-19: advances, gaps and perspectives

Fan, C., Wu, Y., Xiong, R., Yang, Y., Ling, C., Liu, S., Liu, S., & Wang, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01087-8 · Cited by 110

Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model

Garnsey, M. R., Robinson, M. C., Nguyen, L. T., Cardin, R. D., Tillotson, J., Mashalidis, E. H., Yu, A., Aschenbrenner, L. M., Balesano, A., Behzadi, A., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado4288 · Cited by 68

Lung repair and regeneration: Advanced models and insights into human disease

Basil, M. C., Alysandratos, K., Kotton, D. N., & Morrisey, E. E. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.02.009 · Cited by 65

Advances in Rodent Experimental Models of Sepsis

Cai, L., Rodgers, E. G., Schoenmann, N., & Raju, R. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119578 · Cited by 66

Modelling host–microbiome interactions in organ-on-a-chip platforms

Shin, Y. C., Than, N., Min, S., Shin, W., & Kim, H. J. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00130-9 · Cited by 58

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

Yang, Z., Johnson, B. A., Meliopoulos, V., Ju, X., Zhang, P., Hughes, M. P., Wu, J., Koreski, K. P., Clary, J. E., Chang, T., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113965 · Cited by 56

Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response

Wang, X., Yuen, T. T., Dou, Y., Hu, J., Li, R., Zeng, Z., Lin, X., Gong, H., Chan, C. H.-C., Yoon, C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39096-y · Cited by 42

SARS‐CoV‐2 and natural infection in animals

Qiu, X., Liu, Y., & Sha, A. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28147 · Cited by 42

Organoids in virology

Chu, J. T. S., & Lamers, M. M. (2024) · npj Viruses · doi:10.1038/s44298-024-00017-5 · Cited by 31

SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure

Monu, M., Ahmad, F., Olson, R. M., Balendiran, V., & Singh, P. K. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012156 · Cited by 24

Adverse outcomes in SARS-CoV-2–infected pregnant mice are gestational age–dependent and resolve with antiviral treatment

Creisher, P. S., Perry, J. L., Zhong, W., Lei, J., Mulka, K. R., Ryan, W. H., Zhou, R., Akin, E., Liu, A., Mitzner, W., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170687 · Cited by 23

Interferons—Implications in the Immune Response to Respiratory Viruses

Bergeron, H. C., Hansen, M. R., & Tripp, R. A. (2023) · Microorganisms · doi:10.3390/microorganisms11092179 · Cited by 23

An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models

Yuen, C., Wong, W., Mak, L., Lam, J.-Y., Cheung, L.-Y., Cheung, D. T.-Y., Ng, Y.-Y., Lee, A. C.-Y., Zhong, N., Yuen, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42349-5 · Cited by 25

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities

Kumar, R., Aktay-Cetin, Ö., Craddock, V. D., Morales‐Cano, D., Kosanovic, D., Cogolludo, A. L., Pérez‐Vizcaíno, F., Avdeev, S. N., Kumar, A., Ram, A. K., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011063 · Cited by 16

Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters

Mohandas, S., Shete, A. M., Kumar, A., Wakchaure, K., Rai, V., Mote, C., Dighe, H., Sarkale, P., Gawande, P., Yemul, J., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1183763 · Cited by 15

COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses

Chen, Y., Song, W., Li, C., Wang, J., Liu, F., Ye, Z., Ren, P., Tong, Y., Li, J., Ou, Z., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104485 · Cited by 16

Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

Andrade, V. M., Maricic, I., Kalia, R., Jachimowicz, L. A., Bedoya, O., Kulp, D. W., Humeau, L. M. P. F., & Smith, T. R. F. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2281733 · Cited by 15

Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations

Lima, G. G., Portilho, A. I., & Gaspari, E. D. (2022) · Pathogens · doi:10.3390/pathogens12010020 · Cited by 13

Targeting ACLY efficiently inhibits SARS-CoV-2 replication

Yuen, T. T., Chan, J. F., Yan, B., Shum, C. C.-Y., Liu, Y., Shuai, H., Hou, Y., Huang, X., Hu, B., Chai, Y., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72709 · Cited by 12

Schizophrenia and the COVID-19 pandemic: A narrative review from the biomedical perspective

Kowalski, K., & Misiak, B. (2023) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2023.04.002 · Cited by 15

The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management

Becker, R. C., Tantry, U. S., Khan, M. H., & Gurbel, P. A. (2024) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-024-03028-4 · Cited by 14

Mechanistic insights into bone remodelling dysregulation by human viral pathogens

Caetano, C. C. D. S., Azamor, T., Meyer, N. M., Onwubueke, C., Calabrese, C. M., Calabrese, L. H., Visperas, A., Piuzzi, N. S., Husni, M. E., Foo, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01586-6 · Cited by 13

SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in a hamster model

Sardarni, U. K., Ambikan, A. T., Acharya, A., Johnson, S. D., Avedissian, S. N., Végvári, Á., Neogi, U., & Byrareddy, S. N. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.032 · Cited by 11

Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology

Ueki, H., Wang, I.-H., Kiso, M., Horie, K., Iida, S., Mine, S., Ujie, M., Hsu, H.-W., Wu, C.-H. H., Imai, M., et al. (2025) · The Journal of Immunology · doi:10.1038/s41467-024-55272-0 · Cited by 11

Comparative Pathogenesis of Severe Acute Respiratory Syndrome Coronaviruses

Zhang, J., Rissmann, M., Kuiken, T., & Haagmans, B. L. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052620-121224 · Cited by 10

Characterization of Three Variants of SARS-CoV-2 In Vivo Shows Host-Dependent Pathogenicity in Hamsters, While Not in K18-hACE2 Mice

Chávez‐Calvillo, G., Burns, W., Garcia, L., Henry, G., Biancofiori, A., George, A., Duffy, C., Chu, J., Sides, M., Muñoz, M., et al. (2022) · Viruses · doi:10.3390/v14112584 · Cited by 10

Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine

Qin, J., Jeon, J. H., Xu, J., Langston, L. K., Marasini, R., Mou, S., Montoya, B., Melo‐Silva, C. R., Jeon, H. J., Zhu, T., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126392 · Cited by 11

Pathogenicity of SARS-CoV-2 Omicron Subvariants JN.1, KP.2, and EG.5.1 in K18-hACE2 Transgenic Mice

Patterson, L. D., Elsharkawy, A., Jahantigh, H. R., Nabi, Z., Stone, S., & Kumar, M. (2025) · Viruses · doi:10.3390/v17091177 · Cited by 9

SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

Kim, E., Khan, M. S., Ferrari, A., Huang, S., Sammartino, J. C., Percivalle, E., Kenniston, T. W., Cassaniti, I., Baldanti, F., & Gambotto, A. A. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04363-22 · Cited by 10

A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster ModelPreprint

Prakash, S., Dhanushkodi, N. R., Singer, M., Quadiri, A., Zayou, L., Vahed, H., Coulon, P.-G. A., Ibraim, I. C., Tafoya, C., Hitchcock, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.14.580225 · Cited by 10

A single immunization with intranasal Newcastle disease virus (NDV)-based XBB.1.5 variant vaccine reduces disease and transmission in animals against matched-variant challenge

Slamanig, S., Lemus, N., Lai, T. Y., Singh, G., Mishra, M., Abdeljawad, A., Boza, M., Dolange, V., Singh, G., Lee, B., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126586 · Cited by 8

Helicobacter pullorum and Helicobacter canadensis: Etiology, pathogenicity, epidemiology, identification, and antibiotic resistance implicating food and public health

Akhlaghi, H., Javan, A. J., & Chashmi, S. H. E. (2024) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2024.110573 · Cited by 8

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

Peidli, S., Nouailles, G., Wyler, E., Adler, J. M., Kunder, S., Voß, A., Kazmierski, J., Pott, F., Pennitz, P., Postmus, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114328 · Cited by 6

Ensemble modeling of SARS-CoV-2 immune dynamics in immunologically naïve rhesus macaques predicts that potent, early innate immune responses drive viral elimination

Byrne, C., & Schiffer, J. T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1426016 · Cited by 6

Sphingosine-1-Phosphate as Lung and Cardiac Vasculature Protecting Agent in SARS-CoV-2 Infection

Karam, M., & Auclair, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713088 · Cited by 7

Molnupiravir Revisited—Critical Assessment of Studies in Animal Models of COVID-19

Rasmussen, H. B., & Hansen, P. R. (2023) · Viruses · doi:10.3390/v15112151 · Cited by 7

Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant

Cianfarini, C. L., Hassler, L., Wysocki, J. A., Hassan, A., Nicolaescu, V. I., Elli, D., Gula, H., Ibrahim, A. M., Randall, G. C., Henkin, J., et al. (2024) · Cells · doi:10.3390/cells13030203 · Cited by 7

Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)

Arora, H., Kernot, D., Giron, L., Howells, D., Darcy, M., Hoshino, M., Uesugi, K., van Loon, R., TANAKA, G., & Sera, T. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117588 · Cited by 6

Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

Zheng, H., 中国科学院昆明动物研究所遗传资源与进化国家重点实验室, 生., Song, T., Zheng, Y., & 中国科学院昆明动物研究所模式动物表型与遗传研究国家重大科技基础设施(灵长类设施), 国. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.062 · Cited by 6

Predicting Clinical Outcomes of SARS‐CoV‐2 Drug Efficacy with a High‐Throughput Human Airway Microphysiological System

Quezada, L. A. L., Medie, F. M., Luu, R. J., Gaibler, R. B., Gabriel, E. P., Rubio, L. D., Mulhern, T. J., Marr, E. E., Borenstein, J. T., Fisher, C. R., et al. (2024) · Advanced Biology · doi:10.1002/adbi.202300511 · Cited by 9

Investigations on the Potential Role of Free-Ranging Wildlife as a Reservoir of SARS-CoV-2 in Switzerland

Kuhn, J., Marti, I. A., Ryser‐Degiorgis, M., Wernike, K., Jones, S., Tyson, G. B., Delalay, G., Scherrer, P., Borel, S., Hosie, M. J., et al. (2024) · Viruses · doi:10.3390/v16091407 · Cited by 6

An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters

Föderl-Höbenreich, E., Izadi, S., Hofacker, L., Kienzl, N. F., Castilho, A., Strasser, R., Tarrés-Freixas, F., Cantero, G., Roca, N., Pérez, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-95494-w · Cited by 6

Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies

Thomas, D., Yang, P. C.-M., Wu, J. C., & Sayed, N. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.09.008 · Cited by 6

Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Keitany, G. J., Rubin, B. E., Garrett, M. E., Musa, A., Tracy, J., Liang, Y., Ebert, P., Moore, A. J., Guan, J., Eggers, E. L., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.011 · Cited by 5

Development of a Mouse-Adapted Reporter SARS-CoV-2 as a Tool for Two-Photon In Vivo Imaging

Ueki, H., Kiso, M., Furusawa, Y., Iida, S., Yamayoshi, S., Nakajima, N., Imai, M., Suzuki, T., & Kawaoka, Y. (2024) · Viruses · doi:10.3390/v16040537 · Cited by 5

SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus

Lee, Y. S., Woo, J. S., Jhun, J., Choi, J. W., Lee, A. R., Lee, K. H., Choi, H., Park, S., & Cho, M. (2024) · Lupus Science & Medicine · doi:10.1136/lupus-2023-001104 · Cited by 5

Kidney Disease and Viral Infection in COVID-19: Why Are Kidney Organoid and Biopsy Studies Not in Agreement?

Nicosia, R. F. (2023) · The Nephron journals/Nephron journals · doi:10.1159/000528460 · Cited by 5

Adaptation of SARS-CoV-2 to ACE2 H353K mice reveals new spike residues that drive mouse infection

Li, K., Verma, A., Li, P., Ortiz, M. E., Hawkins, G. M., Schnicker, N., Szachowicz, P. J., Pezzulo, A. A., Wohlford-Lenane, C., Kicmal, T., et al. (2024) · Journal of Virology · doi:10.1128/jvi.01510-23 · Cited by 7

Alterations of whole body glucose metabolism in a feline SARS-CoV-2 infection model

Rochowski, M. T., Jayathilake, K., Balcerak, J.-M., Selvan, M. T., Gunasekara, S., Rudd, J. M., Miller, C., & Lacombe, V. A. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2023 · Cited by 5

Effects of immunoproteasome inhibition on acute respiratory infection with murine hepatitis virus strain 1

Steigmann, J. C., Zhou, X., Suttenberg, L. N., Salman, I., Rehmathullah, Z. F., & Weinberg, J. B. (2024) · Journal of Virology · doi:10.1128/jvi.01238-24 · Cited by 4

Generation of a lethal mouse model expressing human ACE2 and TMPRSS2 for SARS-CoV-2 infection and pathogenesis

Jeong, G. U., Hwang, I., Lee, W., Choi, J. H., Yoon, G. Y., Kim, H. S., Yang, J., Kim, K.-C., Lee, J.-Y., Kim, S., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01197-z · Cited by 4

A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV

Guan, X., Verma, A. K., Wang, G., Roy, A., Perlman, S. M., & Du, L. (2024) · Vaccines · doi:10.3390/vaccines12060605 · Cited by 4

An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection

Grabherr, S., Waltenspühl, A., Büchler, L., Lütge, M., Cheng, H., Firner, S., Ludewig, B., Krebs, P., & Pikor, N. B. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200533 · Cited by 4

Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity

Zhou, Y. M., Cheng, T., Tang, K., Li, H., Luo, C., Fu, Y., Xiao, F., Jin, L., Hung, I. F., Lu, L., et al. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110205 · Cited by 4

How SARS-CoV-2 Big Data Are Challenging Viral Taxonomy Rules

Focosi, D., & Maggi, F. (2023) · Viruses · doi:10.3390/v15030715 · Cited by 4

The PTP4A3 inhibitor KVX-053 reduces Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virulence, inflammation, and development of acute lung injury in K18-hACE2 mice

Biancatelli, R. M. L. C., Solopov, P. A., Woodson, C. M., Allen, I. C., Akhrymuk, I. V., Akhrymuk, M., Heath, B. N., Ivester, H. M., Day, T., Austin, D. E., et al. (2025) · Respiratory Research · doi:10.1186/s12931-025-03349-9 · Cited by 3

The use of performance-based outcomes in achieving better global harmonisation in the care and use of animals in research

Rowlands, D. K., & Guillén, J. (2025) · Laboratory Animals · doi:10.1177/00236772241309745 · Cited by 3

Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters

Fitzpatrick, C., Meunier, N., Poder, S. L., Dhorne‐Pollet, S., Costa, B. D., Klonjkowki, B., Eléouët, J., Burzio, V. A., Delmas, B., & Barrey, É. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102612 · Cited by 3

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—SARS-CoV-2

Blacksell, S. D., Dhawan, S., Kusumoto, M., Le, K. K., Summermatter, K., O'Keefe, J., Kozlovac, J. P., Almuhairi, S. S., Sendow, I., Scheel, C. M., et al. (2023) · Applied Biosafety · doi:10.1089/apb.2022.0039 · Cited by 3

A humanized ACE2 mouse model recapitulating age‐ and sex‐dependent immunopathogenesis of COVID‐19

Park, U., Lee, J. H., Kim, U., Jeon, K., Kim, Y., Kim, H. R., Kang, J.-I., Park, M. Y., Park, S. H., Cha, J. S., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29915 · Cited by 5

Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection

Bhattarai, S., Kaufmann, E., Liang, F., Zheng, Y., Gusev, E., Hamid, Q. A., Ding, J., Divangahi, M., & Petrof, B. J. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13705 · Cited by 3

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 HamstersPreprint

Dong, M., Lin, H., Pan, M., Huang, M., Liu, M., Jiang, R.-D., Lai, Y., Shi, A., Yao, B., Hu, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.19.581112 · Cited by 3

Targeting P2X7 mitigates neurobehavioural alterations in a mouse model of post-acute sequelae of SARS-CoV-2 infection

Szabó, D., Tod, P., Maácz, F., Gölöncsér, F., Iring-Varga, B., Török, B., Zsidei, G., Pályi, B., Kis, Z., & Sperlágh, B. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110566 · Cited by 2

Post Pandemic Problem, is there an animal model suitable to investigate PASC

van der Bie, J., Coléon, A., Visser, D., Bogers, W. M. J. M., den Dunnen, J., Spronk, H. M. H., Langermans, J. A. M., Willemen, H. L. D. M., de Melo, G. D., Middeldorp, J., et al. (2025) · npj Imaging · doi:10.1038/s44303-025-00101-2 · Cited by 2

Comparative study of the pathogenicity of SARS-CoV-2 B.1 AND B.1.617.2 lineages for syrian hamsters

Yakovlev, K. S., Mezhenskaya, D. А., Сивак, К. В., Георгиевна, Р. Л., & Isakova–Sivak, I. (2022) · Medical academic journal · doi:10.17816/maj109066 · Cited by 2

Report from an ICT 2022 workshop on toxicology for Covid19 vaccines: Industry, regulatory and CRO perspectives

Gould, S., Wrzesinski, C., Stebbings, R., & Segal, L. M. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.08.040 · Cited by 2

Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling

Lui, W., Ong, C. P., Cheung, P. H., Ye, Z., Chan, C., To, K. K., Yuen, K., & Jin, D. (2024) · mBio · doi:10.1128/mbio.00392-24 · Cited by 2

Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters

Handrejk, K., Schmitz, K. S., Kroeze, E. J. B. V., van Dijk, L. L. A., van Run, P., Haagmans, B. L., Moscona, A., Porotto, M., de Swart, R. L., de Vries, R. D., et al. (2024) · npj Viruses · doi:10.1038/s44298-024-00061-1 · Cited by 2

Characterization of Pulmonary Pathology in the Golden Syrian Hamster Model of COVID-19 Using Micro-Computed Tomography

Ramirez, J. A., Dunlap, M. D., Prosnitz, R., Watson, A., Montgomery, M. K., Gutman, M. R., Coskran, T., Levinson, S. L., Yang, K. L., Kanevsky, I., et al. (2024) · Toxicologic Pathology · doi:10.1177/01926233241300451 · Cited by 2

Revisiting the monocrotaline‐treated rat as a model of inflammatory lung disease: COVID ‐19 and future pandemic threats?

Kris, L. P., Dixon, D., Bihari, S., & Carr, J. M. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70099 · Cited by 2

Potential role of AIM2 inflammasome in SARS‐CoV ‐2 infection

Uresti‐Rivera, E. E., & García-Hernández, M. H. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13239 · Cited by 2

Vaccine Based on Recombinant Fusion Protein Combining Hepatitis B Virus PreS with SARS-CoV-2 Wild-Type- and Omicron-Derived Receptor Binding Domain Strongly Induces Omicron-Neutralizing Antibodies in a Murine Model

Gattinger, P., Kratzer, B., Sehgal, A. N. A., Ohradanova‐Repic, A., Gebetsberger, L., Tajti, G., Focke‐Tejkl, M., Schaar, M., Fuhrmann, V., Petrowitsch, L., et al. (2024) · Vaccines · doi:10.3390/vaccines12030229 · Cited by 3

Uncovering the Contrasts and Connections in PASC: Viral Load and Cytokine Signatures in Acute COVID-19 versus Post-Acute Sequelae of SARS-CoV-2 (PASC)

Compeer, B., Neijzen, T. R., van Lelyveld, S. F. L., Martina, B. E. E., Russell, C. A., & Goeijenbier, M. (2024) · Biomedicines · doi:10.3390/biomedicines12091941 · Cited by 2

Editorial: Emerging bioanalytical techniques and therapies for human disease models

Wang, X., Lu, J., Huang, Y., Liu, X., Fang, G., Yang, C., & Guo, Z. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1453813 · Cited by 2

Nontraditional models as research tools: the road not taken

Kiaris, H. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.07.005 · Cited by 1

Translational research on pandemic virus infection using nonhuman primate models

Ishigaki, H., & Itoh, Y. (2025) · Virology · doi:10.1016/j.virol.2025.110511 · Cited by 1

An in vivo NanoBiT-based pseudoviral biosensor for real-time monitoring of SARS-CoV-2 spike/hACE2 interactions and therapeutic screening

Lin, C., Lin, M., Yang, X., Chiang, H.-H., Wu, T.-H., Tsai, C.-H., & Lin, C. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344623 · Cited by 1

Exploiting Pharmacokinetic/Pharmacodynamic Methods for Optimizing and Accelerating Drug Development of Innovative Anti‐Infectives

Rox, K. (2026) · ChemMedChem · doi:10.1002/cmdc.202500743 · Cited by 1

Prolonged dysregulation and pathological changes in the upper respiratory tract of SARS-CoV-2 infected hamsters

Liu, F., Xia, Y., Lee, A. C.-Y., Chen, Y., Chen, Z., He, Y., Chan, C. H.-C., Cai, J., Yuen, T. T., Ye, Z., et al. (2026) · npj Viruses · doi:10.1038/s44298-026-00181-w · Cited by 1

SARS-CoV-2 Effects on Respiratory and Neurological Systems: Morphological Findings and Gene Expression in K18-hACE2 Mice Model

de Almeida, A. L. T., da Silva, A. M. V., Souza, M. M. E., Rodrigues, M. T., Coelho, F. S., da Rosa, L. C., Azamor, T., Várady, C. B. S., da Silva, B. J. D., de Almeida, A. C., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14040852 · Cited by 1

Persistent neurological and behavioral alterations after SARS-CoV-2 infection in an optimized K18-hACE2 mouse model

Ruiz-Casas, C., Tarrés-Freixas, F., Roca, N., Pérez, M., Contreras, E., Martín, L., Bernaus, O., Olvera, À., Ruiz‐Riol, M., Brander, C., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1871084 · Cited by 1

Quality Management and Animal Welfare as Culture of Care for Animal Experiments under Biosafety Level-3, taking COVID-19 as a Practical Example

Richter, A., Wirz, K., Pilchová, V., Schulz, C., Volz, A., & von Köckritz‐Blickwede, M. (2024) · Journal of Applied Animal Ethics Research · doi:10.1163/25889567-bja10047 · Cited by 1

Elimination of olfactory sensory neurons by zinc sulfate inoculation prevents SARS-CoV-2 infection of the brain in K18-hACE2 transgenic mice

Lee, J.-H., Yoo, E., Kim, N.-W., Shim, W.-Y., Jeong, H.-B., Kim, D.-H., Park, Y.-J., Seo, S.-M., Yun, J.-W., Park, J. W., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78538-5 · Cited by 1

American mink as an animal model to study SARS-CoV-2 and vaccine responsePreprint

Aaltonen, K., Virtanen, J. M. E., Kegler, K., Venkat, V., Kareinen, L., Korhonen, E. M., Niamsap, T., Malmgren, R., Korpela, J., Naves, R. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658224 · Cited by 1

An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cellsPreprint

Daher, U., Vallone, V. B. F., Baumgardt, M., Obermayer, B., Wiese, N., Kirsch, A. K., Fisch, T., Löwa, A., Schmueck‐Henneresse, M., Hocke, A. C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.16.676521 · Cited by 1

Novel platelet glycoprotein VI and CLEC-2 targeting strategies

Navarro, S. (2023) · doi:10.26481/dis.20230425sn

TISSUE-SPECIFIC METABOLOMIC REPROGRAMMING DETERMINES THE DISEASE PATHOPHYSIOLOGY OF SARS-COV-2 VARIANTS IN HAMSTER MODELPreprint

Sardarni, U. K., Ambikan, A. T., Acharya, A., Johnson, S. D., Avedissian, S. N., Végvári, Á., Neogi, U., & Byrareddy, S. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.25.581989

Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research

Gorskaya, A., & Vasilev, D. S. (2024) · Сенсорные системы · doi:10.31857/s0235009224010017

Computational modeling and inhibition of SARS-COV-2 Papain-like protease enzyme: A potential therapeutic approach for COVID-19

Auwal, A. R., Baba, I. A., Hınçal, E., & Rihan, F. A. (2024) · Journal of Biosafety and Biosecurity · doi:10.1016/j.jobb.2024.07.001

Problems in the Diagnosis of Dysfunctions of the Olfactory Analyzer in Laboratory Animals Based on Behavioral and Electrophysiological Study Methods

Gorskaya, A., & Vasilev, D. S. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01702-x

A survey of SARS-CoV-2 tropism

Jin, X., Ren, X., Ren, X., & Wang, J. (2025) · Infectious Diseases & Immunity · doi:10.1097/id9.0000000000000166

Poldip2 deficiency attenuates disease severity in a mouse model of COVID-19Preprint

Hu, R., Valdivia, A., White, T. E., Ju, W., Brockman, M. L., Zhang, Z., Qu, H., Gafford, G. M., Joseph, G., Burton, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.17.657579

A Multi-Antigen Broad-Spectrum Coronavirus Vaccine Induces Potent and Durable Cross- Protection Against Infection and Disease Caused by Multiple SARS-CoV-2 VariantsPreprint

Prakash, S., Dhanushkodi, N. R., Quadiri, A., Vahed, H., Chentoufi, A. A., Coulon, P.-G. A., Ibraim, I. C., Babsiri, A. E., Tifrea, D. F., Figueroa, C. J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7208748/v1

Susceptibility of different mouse strains to SARS-CoV-2 spike receptor-binding domain protein-induced lung inflammation: a comparative study

Ha, Y., Lee, Y. H., Jo, H.-S., Kwon, T. W., Seo, Y., Kim, D. W., & Cho, I. (2025) · Journal of General Virology · doi:10.1099/jgv.0.002148

An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cellsPreprint

Amini, L., Daher, U., Vallone, V. B. F., Baumgardt, M., Obermayer, B., Wiese, N., Kirsch, A. K., Fisch, T., Löwa, A., Schmueck‐Henneresse, M., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7871790/v1

SARS-CoV-2 immunity in animal models

Chen, Z., Yuan, Y., Hu, Q., Zhu, A., Chen, F., Li, S., Guan, X., Lv, C., Tang, T., He, Y., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01122-w · Cited by 39

Animal models for SARS‐CoV‐2 infection and pathology

Bi, Z., Hong, W., Yang, H. J., Lu, S., & Peng, X. (2021) · MedComm · doi:10.1002/mco2.98 · Cited by 35

Animal Models for SARS-CoV-2 research: Systematic Review of Literature and Future DirectionsPreprint

Pandey, K., Acharya, A., Mohan, M., Ng, C., Reid, P., & Byrareddy, S. N. (2020) · doi:10.22541/au.159284811.17251473

Mouse models in COVID-19 research: analyzing the adaptive immune response

Clever, S., & Volz, A. (2022) · Medical Microbiology and Immunology · doi:10.1007/s00430-022-00735-8 · Cited by 26

Animal models: important tools for studying SARS-Cov-2 infection

Morosan, S., Cozma, A., & Dascălu, M. A. (2023) · Lucrări Ştiinţifice - Medicină Veterinară, Universitatea de Ştiinţe Agricole şi Medicină Veterinară "Ion Ionescu de la Brad" Iaşi · doi:10.61900/spjvs.2023.03.16