Cited by 217Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model

Open access

Jorfi, Mehdi, Park, Joseph, Hall, Clare K., Lin, Chih-Chung Jerry, Chen, Meng, von Maydell, Djuna, Kruskop, Jane M., Kang, Byunghoon, Choi, Younjung, Prokopenko, Dmitry, Irimia, Daniel, Kim, Doo Yeon, Tanzi, Rudolph E.·2023·Nature Neuroscience

DOI 10.1038/s41593-023-01415-3PMC PMC11184920

Open this paper in CoChat — free account Open PDF

Abstract

Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model comprising stem cell-derived neurons, astrocytes and microglia, together with peripheral immune cells. We observed an increase in the number of T cells (but not B cells) and monocytes selectively infiltrating into AD relative to control cultures. Infiltration of CD8+ T cells into AD cultures led to increased microglial activation, neuroinflammation and neurodegeneration. Using single-cell RNA-sequencing, we identified that infiltration of T cells into AD cultures led to induction of interferon-γ and neuroinflammatory pathways in glial cells. We found key roles for the C-X-C motif chemokine ligand 10 (CXCL10) and its receptor, CXCR3, in regulating T cell infiltration and neuronal damage in AD cultures. This human neuroimmune axis model is a useful tool to study the effects of peripheral immune cells in brain disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41593-023-01415-3

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Integrated analysis of multimodal single-cell data
Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Hao, Y., Stuart, T., Kowalski, M. H., Choudhary, S., Hoffman, P., Hartman, A., Srivastava, A., Molla, G., Madad, S., Fernandez-Granda, C., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-01767-y · Cited by 5,631
NicheNet: Modeling intercellular communication by linking ligands to target genes
Browaeys, R., Saelens, W., & Saeys, Y. (2020) · Nature Methods · doi:10.1038/s41592-019-0667-5 · Cited by 2,192
A three-dimensional human neural cell culture model of Alzheimer’s disease
Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D’Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., et al. (2014) · Nature · doi:10.1038/nature13800 · Cited by 1,195
Self-citation
iPSC-derived human microglia-like cells to study neurological diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154
CXCR3 in T cell function
Groom, J. R., & Luster, A. D. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.12.017 · Cited by 1,005
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., et al. (2020) · Nature · doi:10.1038/s41586-019-1895-7 · Cited by 992
The Chemokine System in Innate ImmunityPreprint
Sokol, C. L., & Luster, A. D. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016303 · Cited by 897
Intravascular staining for discrimination of vascular and tissue leukocytes
Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812

Show all 61 references

Research works printed but not linked: 1

Schulz, O., Hammerschmidt, S. I., Moschovakis, G. L. & Förster, R. Chemokines and chemokine receptors in lymphoid tissue dynamics. Annu. Rev. Immunol. 34, 1–40 (2015).

Sorted by citations

Items 101–200 of 217

CXCR3 Deficiency Alleviates Retinal Ganglion Cell Loss by Regulating Neuron–Astrocyte Communication in a Mouse Model of Glaucoma
Xia, F., Shi, S., Palacios, E., Ju, W., Liu, H., & Zhang, W. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.14.42 · Cited by 4
Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation
Jackson, M. S., Porter, L. G., & Oakes, R. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1677612 · Cited by 7
Bibliometric and visual analysis of single-cell multiomics in neurodegenerative disease arrest studies
Wang, J., Wang, S., Li, Q., Liu, F., Wan, Y., & Liang, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1450663 · Cited by 4
Novel insights from comprehensive analysis: The role of cuproptosis and peripheral immune infiltration in Alzheimer’s disease
Wang, J., Yu, Z.-W., Liu, Q., Wu, J., Zhang, Y.-D., Wan, H., Bi, M., Xiao, N., Zheng, K.-M., & Jiang, B. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325799 · Cited by 4
Plasma ceramide mediates the association of peripheral T cells with Alzheimer’s disease
Sun, Y., Xia, L., Xu, X.-F., Wang, X., Guo, J., Cheng, R., Yang, N., Shen, L., Liu, N., Mo, X., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.027 · Cited by 5
Unveiling Immune-related feature genes for Alzheimer’s disease based on machine learning
Zhang, G., Sun, S., Wang, Y., Zhao, Y., & Sun, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1333666 · Cited by 4
The role of Immune cells in Alzheimer's disease: a bidirectional Mendelian randomization study
Zhang, E., Chen, T., Chen, Y., Long, C., Tao, L., Shen, X., & Dai, F. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1433691 · Cited by 6
The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2
Nuovo, G. J., Rice, M., Zanesi, N., Sawant, D. B., Crilly, C. J., & Tili, E. (2025) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000001251 · Cited by 4
Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer’s diseasePreprint
Zeng, J., Abd-Elraouf, K., Loi, G. W. Z., Saipuljumri, E. N., O’Connor, L. M., Indajang, J., Reynolds, R., Barron, A. M., & Lo, C. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.12.562041 · Cited by 4
Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J. L., Walz, A., Restaino, A. C., Amit, M., Barclay, S. M., Vichaya, E. G., Spanos, W. C., Dantzer, R., Talbot, S., & Vermeer, P. D. (2024) · eLife · doi:10.7554/elife.97916.3 · Cited by 3
MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice
Zhang, Y., Yang, Z., Jiang, N., Tan, X., Jiang, P., Cao, G., & Yang, Q. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03413-7 · Cited by 3
Differential susceptibility to repeated social stress induces synaptic plasticity impairment and cognitive deficit in the 5xFAD mouse model
Yang, E., Rahim, M. A., Masieri, S., & Pasinetti, G. M. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102797 · Cited by 3
Integrated transcriptomic analysis of the temporal cortex identifies CRH and GAD2 as neuropathological markers and reveals altered immune microenvironment in Alzheimer’s disease
Liu, P., Huang, C., Lu, L., Pang, Y. L., & Huang, Z. (2026) · Scientific Reports · doi:10.1038/s41598-026-40762-6 · Cited by 3
Immune cells: Mediators in the metabolites and Alzheimer’s disease
Zhang, E., Dai, F., Tao, L., Chen, Y., Chen, T., & Shen, X. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877241313140 · Cited by 3
RNA Analysis of Circulating Leukocytes in Patients with Alzheimer’s Disease
Okinaka, Y., Shinagawa, Y., Claussen, C., Gul, S., Matsui, I., Matsui, Y., & Taguchi, A. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230874 · Cited by 3
Ad-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of Aβ neuropathology
Iban‐Arias, R., Yang, E., Griggs, E., Portela, A. S. D., Osman, A., Trageser, K. J., Shahed, M. H., & Pasinetti, G. M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.012 · Cited by 3
Glia in Neurodegenerative DiseasePreprint
Crowley, G., Attwell, D., Phatnani, H. P., Sontheimer, H. W., & Hong, S. Y. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041375 · Cited by 3
Bacterial infection hypothesis-based therapies for Alzheimer's disease
Teng, M., Ma, R., Liu, S., Zhang, G., Zou, J., & Fu, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169535 · Cited by 3
Spilling the T: T cells in tauopathy mechanisms, disease progression, and therapeutic horizons
Bosch, M. E., & Ulrich, J. D. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00020-5 · Cited by 3
Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA
Johnson, L. A., Saito, K., Pallerla, A. V., Funnell, J. L., Ezzo, A. R., Song, C. M., Harrison, D. A., Norton, N. J., Moore, L. C., Eldik, L. J. V., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68921-3 · Cited by 5
Fast‐Track to Functional Neurons: Accessible and Minimalistic Neurogenin 2 Programming of Human iPSCs
Harberts, J. I., Siegmund, M., Wollesen, E., Viola, C., Krieg, K., Pleß, O., Elnathan, R., Zierold, R., Blick, R. H., & Voelcker, N. H. (2026) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500221 · Cited by 2
Unique phenotypic and T cell receptor characteristics of CD8+ T cells accumulated in the brains of Alzheimer’s disease mice
Zhihuan, W., Furusawa-Nishii, E., & Miyake, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-38351-8 · Cited by 3
Interleukin-6, CD8+ T cells, and Alzheimer’s disease: unraveling neuroimmune crosstalk via genetic and mechanistic insights
Xu, R., Song, W., & Zhang, X. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1767927 · Cited by 2
The Immune-Chemokine Axis in Alzheimer’s Disease: Roles of Adaptive Immune System in Neuroinflammation and Disease Progression
Merino, J. J., Rodriguez, J. J., Busquets, X., Álvarez-Vicente, I., Cabaña-Muñoz, M. E., Flores, A. I., & Tolédano, A. (2026) · Biomolecules · doi:10.3390/biom16060855 · Cited by 2
Adaptive immunity in the pathogenesis of neurodegeneration
Li, Y., Ulrich, J. D., & Holtzman, D. M. (2026) · Nature Immunology · doi:10.1038/s41590-026-02538-y · Cited by 4
Microglia in Alzheimer’s Disease: From Homeostatic Guardians to Multifaceted Drivers of Neuropathology
Ma, L., Zhao, Y. Q., Cai, C., Qs, L., Hu, X., & Wang, L. (2026) · Cells · doi:10.3390/cells15141291 · Cited by 2
Autoimmune hypothesis of Alzheimer’s disease: unanswered question
Arshavsky, Y. I. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00259.2024 · Cited by 2
Identification and experimental validation of Alzheimer's disease hub genes via bioinformatics and machine learning
Hu, Y., Pan, Z., Li, J., Tang, B., Luo, M., Li, Y., Cao, X., Zheng, K., Wang, N., & Xu, C. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251356300 · Cited by 2
Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
Woo, M. S., Therriault, J., Hosseini, S. A., Wang, Y.-T., Macedo, A. C., Rahmouni, N., Aumont, É., Servaes, S., Tissot, C., Arias, J. F., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00316-1 · Cited by 5
High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the BrainPreprint
Ali, M. A., Siam, M. H. B., Vardaman, D., Bolding, C., Brazell, J. N., Whatley, A. D., Risley, C. A., Tidwell, H., Hossain, S. N., Samal, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.10.693494 · Cited by 2
CD8 + T cells are primed by cDC1 and exacerbate tau-mediated neurodegenerationPreprint
Hu, H., Lin, P. B., Zeng, C., Sharma, P., Li, Y., Jiang, H., Nulman, J., Ohara, R. A., Wu, T., Li, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.26.708260 · Cited by 2
Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain Pro-Inflammatory Microenvironment and Early Spatial Memory Impairment
Farris, T., Ochoa, S. G., Mohammed, M. A., Rajakaruna, H., Tonello, J. M., Kanagasabai, T., Korolkova, O. Y., Shimamoto, A., Ivanova, A. V., & Shanker, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137406 · Cited by 1
Peripheral blood immune cell phenotypes and Alzheimer’s disease: A mediation Mendelian randomization study
Sun, J., Teng, F., Cao, Y., Pei, H., Ma, L., Wei, W., & Li, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251330503 · Cited by 1
Nasal administration of Protollin enhances monocyte phagocytosis and decreases CD8+ T cell cytotoxicity in subjects with early Alzheimer’s disease: a Phase 1 clinical trial
Kolypetri, P., da Silva, P., Francisco, R. D. S., Frenkel, D., Cecere, R. R., Kiliaan, P. C. J., Montini, F., Saxena, S., Clementi, W. A., Liu, X., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00397-3 · Cited by 3
Inflammatory mechanisms underlying early Alzheimer’s disease pathology: evidence from the aging rhesus macaque brain
Datta, D., Wang, M., & Arnsten, A. F. T. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1750092 · Cited by 1
Advances in hiPSC ‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease
Maciel, E. M. A., Silva, N. C., Santos, L. G. P., & Ribeiro, F. M. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70416 · Cited by 1
Glial-neuronal interactions via chemokine signaling in cerebral ischemia: Mechanisms and therapeutic implications
Sharma, A., Mannan, A., Chitranshi, N., Dua, K., & Singh, T. G. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104093 · Cited by 1
Meningeal and infiltrating T-cells are associated with repetitive head trauma and tau-mediated neurodegeneration in chronic traumatic encephalopathy
Calderazzo, S. M., Butler, M. L. M. D., Breen, K., Kanner, H., Tripodis, Y., Stein, T. D., Holtzman, D. M., Cherry, J. D., Huber, B. R., & McKee, A. C. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02285-z · Cited by 2
CMV titer associations with cognition and the plasma proteome implicate FLT1 and neurovascular mechanisms as potential moderators
Duggan, M. R., Jacobsen, E. P., Yang, S., Zeng, X., Kandala, S., Joynes, C. M., Karikari, T. K., Nimgaonkar, V. L., Kamboh, M. I., Snitz, B. E., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03800-8 · Cited by 1
Disulfidptosis in neurodegenerative diseases: From redox imbalance to neuronal dysfunction
Shi, C., Jia, K., Guo, Y., 钱胜浩, Wang, B., Qiu, Y., Li, D., Dang, Z., Xue, K., Gao, F., et al. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116242 · Cited by 1
Mechanisms and Therapeutic Targeting of the Gut Microbiota-Immune-Brain Axis in Alzheimer’s Disease
Wang, S., Yuan, X., Wang, T., Yang, M., Dong, P., & Han, H. (2026) · Immunological Investigations · doi:10.1080/08820139.2026.2669375 · Cited by 1
APOE, Inflammation, and T Cells in Translational Disease Models and Clinical Medicine
Adlimoghaddam, A., Cervantes, D., & Wheeler, C. J. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_35 · Cited by 1
T cell-microglial interactions that impair myelin maintenance and regeneration: cellular mechanisms on white-matter associated changes
Song, C., Lee, Y., & Kim, M. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1813048 · Cited by 1
Neurovascular unit senescence as a driver of blood–brain barrier dysfunction in Alzheimer’s disease：Mechanisms, consequences, and therapeutic implications
Yao, M., Liu, A., Xing, L., Song, J., Yang, Y., Yue, X., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103260 · Cited by 1
Is amyloid beta peptide a driver of inflammaging?
Kechko, O. I., Moskalev, A. A., Franceschi, C., Mitkevich, V. A., & Makarov, A. А. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103280 · Cited by 1
CXCL10 contributes to female-specific pathological progression in tauopathy model mice
Uenishi, R., Kawata, R., Manabe, T., Matsuba, Y., Mihira, N., Takeo, T., Saido, T. C., Hijioka, M., & Saito, T. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03989-8 · Cited by 1
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
Hu, H., Lin, P. B., Zeng, C., Li, Y., Bosch, M. E., Emmerson, J. T., Sharma, P., Ohara, R. A., Dong, W., Wu, T., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02427-5 · Cited by 7
PD-1 deficiency disrupts in vivo neural activity in mouse Hippocampus and cortex
Hu, M., Lv, C., Zhu, J., Zhang, H., Wang, X., You, L., Xie, J., Liu, W., Wei, X., Chen, K., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107002 · Cited by 2
Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in micePreprint
Makhijani, P., Emani, R., Aguirre, C. G., Mu, W., Rane, A., Ng, J. H. Y., Valentino, T. R., Manwaring-Mueller, M., Tan, C. R., Du, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.27.573841 · Cited by 1
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly peoplePreprint
Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutiérrez‐Jiménez, E., Fillmore, N. R., Bubu, O. M., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4076789/v1 · Cited by 1
Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancerPreprint
Barr, J. L., Walz, A., Restaino, A. C., Amit, M., Barclay, S. M., Vichaya, E. G., Spanos, W. C., Dantzer, R., Talbot, S., & Vermeer, P. D. (2024) · eLife · doi:10.7554/elife.97916.2 · Cited by 1
Automated image segmentation uncovers the role of CD74 high human microglia in cognitive declinePreprint
Taga, M. F., Fujita, M., Parghi, N., Haage, V. C., Teich, A. F., Schneider, J. A., Bennett, D. A., Zhang, Y., & Jager, P. L. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.25.672200 · Cited by 1
Brain-Resident CD8 + T Cells Regulate Neuronal Activity and Behavior via Interferon-GammaPreprint
Park, K., Jang, J., Jeon, S., Hwang, S., Choi, K., cox, T., Ngiow, S. F., flores, J., Harrison, C. F., Liu, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.24.746768 · Cited by 1
Is there a role for B cells in Alzheimer's disease?
Charavner, E.-L., Fillatreau, S., & El Behi, M. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105154
Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse modelPreprint
Toral-Ríos, D., Long, J. M., Ulrich, J. D., Yu, J., Strickland, M. R., Han, X., Holtzman, D. M., Cashikar, A. G., & Paul, S. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.08.556884
CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction
Mendes, N. F., Zanesco, A. M., de Aguiar, C. F., Rodrigues-Luiz, G. F., da Silva, D. C., Campos, J. F., Câmara, N. O. S., Moraes‐Vieira, P. M., ARAUJO, E. P. D., & Velloso, L. A. (2024) · eLife · doi:10.7554/elife.95044.3
CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunctionPreprint
Mendes, N. F., Zanesco, A. M., de Aguiar, C. F., Rodrigues-Luiz, G. F., da Silva, D. C., Campos, J. F., Câmara, N. O. S., Moraes‐Vieira, P. M., ARAUJO, E. P. D., & Velloso, L. A. (2024) · eLife · doi:10.7554/elife.95044.1
Circulating inflammatory proteins and risk of Parkinson’s disease and other neurodegenerative disorders: a two-sample Mendelian randomization studyPreprint
Chen, Z., Li, G., Zhou, L., Zhang, L., You, Y., & Liu, J. (2024) · Research Square · doi:10.1101/2024.05.03.24306837
Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer’s diseasePreprint
Rickenbach, C., Mallone, A., Häusle, L., Frei, L., Seiter, S., Sparano, C., Kirabali, T., Blennow, K., Zetterberg, H., Ferretti, M. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.04.597424
Neurological Impact of Type I Interferon Dysregulation
Mylonas, A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006023
Reviewer #3 (Public Review): Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J., Walz, A., Restaino, A. C., et al. (2024) · eLife · doi:10.7554/elife.97916.2.sa1
eLife Assessment: Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Palmiter, R. D. (2024) · eLife · doi:10.7554/elife.97916.2.sa4
Reviewer #1 (Public Review): Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J., Walz, A., Restaino, A. C., et al. (2024) · eLife · doi:10.7554/elife.97916.2.sa3
Reviewer #2 (Public Review): Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J., Walz, A., Restaino, A. C., et al. (2024) · eLife · doi:10.7554/elife.97916.2.sa2
Author response: Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer
Barr, J. L., Walz, A., Restaino, A. C., Amit, M., Barclay, S. M., Vichaya, E. G., Spanos, W. C., Dantzer, R., Talbot, S., & Vermeer, P. D. (2024) · eLife · doi:10.7554/elife.97916.2.sa0
CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunctionPreprint
Mendes, N. F., Zanesco, A. M., de Aguiar, C. F., Rodrigues-Luiz, G. F., da Silva, D. C., Campos, J. F., Câmara, N. O. S., Moraes‐Vieira, P. M., ARAUJO, E. P. D., & Velloso, L. A. (2024) · eLife · doi:10.7554/elife.95044.2
A single Citrobacter rodentium infection in Pink1 knockout and wildtype mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal lossPreprint
Mukherjee, S., Grouza, V., Tchung, A., Even, A., Yaqubi, M., Tuznik, M., Cannon, T., Recinto, S. J., Gavino, C., Bourque, M.-J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.24.630165
Rôle des lymphocytes T résidents mémoires dans les maladies inflammatoires du système nerveux central
Liblau, R. (2025) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2024.11.026
Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment
Monteiro, J. K., & Miron, V. E. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01929-y
Clonal expansion of cytotoxic CD8 + T cells in lecanemab-associated ARIAPreprint
Johnson, L. A., Saito, K., Pallerla, A. V., Funnell, J. L., Ezzo, A. R., Song, C. L., Harrison, D. A., Norton, N. J., Moore, L. C., Eldik, L. J. V., et al. (2025) · medRxiv · doi:10.1101/2025.09.17.25335728
The role of small GTPases in Alzheimer’s disease tau pathologies
Hoegy, P., Chen, Y., & Lu, Q. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1650400 · Cited by 1
How Human Induced Pluripotent Stem Cells‐Derived Models can Advance our Understanding of Secretion Mechanisms in Physiological and Pathological Contexts?
Fourrière, L., & Boncompain, G. (2025) · Biology of the Cell · doi:10.1111/boc.70035
Amyloid-β 42-carrying extracellular vesicles are associated with neurodegeneration and neuroinflammation in Alzheimer’s diseasePreprint
Raich, L., Könken, M., Grochowska, K. M., Puig, B., Mayer, C., Hadjilaou, A., Schlemm, E., Shafiq, M., Thomalla, G., Magnus, T. U., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.27.690912
Additional file 5 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666419
Additional file 3 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666413
Additional file 6 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666422
Additional file 2 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666410
Additional file 4 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666416
Additional file 1 of The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutiérrez‐Jiménez, E., Fillmore, N. R., Gonzalez, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25853015
Additional file 1 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666407
Additional file 7 of CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Figshare · doi:10.6084/m9.figshare.26666425
APOE, Inflammation, and T Cells in Translational Disease Models and Clinical Medicine
Adlimoghaddam, A., Cervantes, D., & Wheeler, C. J. (2026) · Springer eBooks · doi:10.1007/978-3-031-52641-1_35-1
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model of Alzheimer’s disease
Bruna, B., More, J., Lobos, P., Ponce, D. P., Duran-Aniotz, C. A., Valdés, J. L., Gleisner, M. A., Tempio, F., Salech, F., Pizarro, M., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-40699-w
Single-cell multi-omic profiling allows the dissection of peripheral immune phenotypes in Alzheimer’s Disease progressionPreprint
Spintge, J. B., Mai, K., Carraro, C., van Uelft, M., Elli, F., Mauer, K., Holsten, L., Frolov, A., Elangikal, J., Hinkley, E. R., et al. (2026) · medRxiv · doi:10.64898/2026.03.12.26348228
TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology
König, L. E., Rodriguez, S., Hug, C. B., Daneshvari, S., Chung, A., Appleman, M., Tsai, M., Bradshaw, G. A., Şahin, A., Song, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70243-3 · Cited by 7
Peripheral immune profiling in frontotemporal dementia
Gamez, N., Eid, A. M., Pascual, B., Li, D., Wang, Y., Masdeu, J. C., Appel, S. H., & Faridar, A. (2026) · Brain Communications · doi:10.1093/braincomms/fcag089
Applications of in vitro model in Alzheimer’s disease research: From two-dimensional cell models to brain organoids
Du, R.-L. (2023) · New cell · doi:10.61958/ncvv3137
Mechanisms underlying neuroimmune networks as central regulators in combating neurodegenerative diseases
Hu, X., Yao, M., Xu, F., Wang, H., Lu, M., & Chen, Q. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-01276
BAG2 Condensates Couple Proteostasis to CD8 + T Cell SurveillancePreprint
Almeida, M. C., Wang, T., Longhini, A. P., Lobo, S., Camargo, C. M., Tinkle, E. D., Kwon, M., Duarte, G. Z., Hirsch, I. O., Ribeiro, C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.24.719751
The meningeal lymphatic vessel–peripheral immune axis: a novel therapeutic target in neurodegenerative diseases
He, Z., & Sun, J. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03849-5
Microglia crosstalk with T cells in neurodegenerative diseases: pathogenesis and treatment targets
Chen, G., Zhao, C., Wang, C., Chen, G., Shi, J., & Chen, H. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116781
Network-Level Characterization of Spontaneous Calcium Activity in an In-Vitro Alzheimer’s Disease ModelPreprint
Emenheiser, A. M., Gentry, E., Xue, H., Alvarez, P., O’Neill, K. M., Cao, K., & Losert, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.28.728474
CCL21/CCR7 axis-driven CD8+ T cell recruitment and neuroinflammation in diabetic peripheral neuropathyPreprint
Wu, Y., Chong, L., Dong, D., Zhu, L., Luo, H., & Xie, X. (2026) · Research Square · doi:10.21203/rs.3.rs-10023171/v1
Neuronal expression of β2M and MHC I are essential for peripheral surveillance and targeting of neuron-restricted antigens
Clarkson, B. D. S., Schille, M. E., Garland, I. J. Z., Westphal, M. S., & Howe, C. L. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1813496
A single Citrobacter rodentium infection in Pink1 knockout and wild-type mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal loss
Mukherjee, S., Grouza, V., Tchung, A., Even, A., Yaqubi, M., Tuznik, M., Cannon, T., Recinto, S. J., Gavino, C., Bourque, M.-J., et al. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014315 · Cited by 1
Hunting for an Antigen: Humoral Immunity in Alzheimer’s Disease
Delgado, A. M., Greer, B. D., Maul, R. W., & Gearhart, P. J. (2026) · Cells · doi:10.3390/cells15131227
Autoimmune signatures in neurodegenerative dementias: from peripheral immune activation to CNS pathology
Zhao, X., Zhang, G., Wang, Z., Zhang, D. J., Xia, Z., & Huo, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1893167
Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection
Aldana, B. I., & Freude, K. (2026) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70273
Targeting IL-33 in Precision Neuroimmunology: Cellular Mechanisms and Therapeutic Strategies for CNS Disorders
Li, L., Wang, S., Duan, L., Zhang, L., Yan, H., Zhu, Y., Tao, L., & Gao, Y. N. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-026-10302-0 · Cited by 1
Association between Alzheimer’s disease and MHC-I antigen processing and presentation pathway: a narrative review
Wang, C., Yun, Q. I., Zhang, Z., Zhao, H., Lin, F., & Cao, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1877167

Authors: Jorfi, M., Park, J., Hall, C. K., Lin, C.-C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., Irimia, D., Kim, D. Y., & Tanzi, R. E.
Affiliations: Harvard University (US)
Massachusetts General Hospital (US)
Corresponding author: Jorfi, Mehdi
Kim, Doo Yeon
Tanzi, Rudolph E.
ORCID: Jorfi, Mehdi
Park, Joseph
Lin, Chih-Chung Jerry
Prokopenko, Dmitry
Irimia, Daniel
Kim, Doo Yeon
Tanzi, Rudolph E.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2023-08-24
Volume: 26
Issue: 9
Pages: 1489-1504
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-023-01415-3
PMC: PMC11184920
OpenAlex: W4386134158
Cited by: 214
References: 61
Citations by year: 2026: 68 · 2025: 65 · 2024: 74 · 2023: 7
FWCI: 22.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Cure Alzheimer’s Fund
JPB Foundation
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, CD8+ T cells, T cell infiltration, neuroinflammation, microglial activation, neurodegeneration, CXCL10, CXCR3, interferon-gamma, peripheral immune cells, stem cell-derived neurons, astrocytes, monocytes
MeSH terms: Alzheimer Disease, Humans, Neuroglia, Neurons, Neuroimmunomodulation, CD8-Positive T-Lymphocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks