Myelin lipid metabolism can provide energy for starved axons
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Glucose, glycolytic substrates (lactate, pyruvate), and ketone bodies are transported from the myelinic channel space into axons by GLUT1 and MCT1 transporters.
“Glucose, glycolytic substrates (lactate, pyruvate) [280,281], and ketone bodies (acetoacetate and β-hydroxybutyrate) [282,283] are transported from this space into axons by their glucose transporter protein type-1 (GLUT1) and monocarboxylate transporter-1 (MCT1) transporters, respectively [237].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [237]
Cites
White matter integrity in mice requires continuous myelin synthesis at the inner tongue
Meschkat, M., Steyer, A. M., Weil, M.-T., Kusch, K., Jahn, O., Piepkorn, L., Agüi-Gonzalez, P., Phan, N. T. N., Ruhwedel, T., Sadowski, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28720-y · Cited by 112 · see citing works
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Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works
- Venue
- Nature Neuroscience
- Published
- 2024-09-12
- Volume
- 27
- Issue
- 10
- Pages
- 1862-1863
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W4402479037
- Cited by
- 4
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- oligodendrocytes, myelin sheath, axonal energy metabolism, glucose deprivation, white matter tracts, myelinated axons, lipid turnover
- MeSH terms
- Animals, Axons, Energy Metabolism, Humans, Myelin Sheath, Lipid Metabolism
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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