DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

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ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

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GtRNAdb: a database of transfer RNA genes detected in genomic sequence

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The quantitative proteome of a human cell line

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Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

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DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

Cheung-Ong, K., Giaever, G. N., & Nislow, C. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.04.007 · Cited by 608

Design of antisense oligonucleotides stabilized by locked nucleic acids

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Clinical insight on the pathway of SLFN11 as emergent biomarker in SCLC

Scattolin, D., Heijboer, F. W. J., Derks, J. L., von der Thüsen, J. H., Dumoulin, D. W., Speel, E. M., Guarneri, V., Pasello, G., & Dingemans, A. C. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104901 · Cited by 4

Proteostasis Deregulation by Metabolism Drives the Hallmarks of Cancer

Venkitaraman, A. R. (2026) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051424-052148 · Cited by 4

Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis

Greulich, H. E. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.05.012 · Cited by 4

The regulation, function and disease relevance of cytoplasmic tRNAs

Stanley, R. E., Lowe, T. M., & Ignatova, Z. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-00963-3 · Cited by 5

Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor Payloads

Pommier, Y. G. (2026) · Journal of Molecular Biology · doi:10.1016/j.jmb.2026.169841 · Cited by 4

Structural and functional characterization of human SLFN14

Luo, M., Jia, X., Wang, Z., Yang, J. Y., Wang, W., Chen, J., Ou, J.-Y., Feng, J.-X., Yu, B., Wang, S., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf484 · Cited by 4

SLFN11 Restricts LINE-1 Mobility

Ye, Z., Duan, Y., Zhang, A., Zhang, Z., Guo, S., Liu, Q., Yi, D., Wang, X., Zhao, J., Li, Q., et al. (2025) · Cells · doi:10.3390/cells14110790 · Cited by 2

Learning from nature: HIV elite controllers as blueprints for a functional cure

Kalidasan, V., & Das, K. T. (2025) · Virology Journal · doi:10.1186/s12985-025-03042-9 · Cited by 3

Context-specific Angiogenin-mediated tRNA fragments (tDRs) biogenesis shapes the mitochondrial stress response

Al-Mesitef, S., Ando, D., Saigasaki, T., Sakaguchi, Y., Akagi, S., Mousa, A., Rashad, S., & Niizuma, K. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104038 · Cited by 2

Targeting SLFN11-regulated pathways restores chemotherapy sensitivity in AML

Small, S. H., Perez, R. E., Beauchamp, E. M., Baran, A. H., Willis, S. D., Fischietti, M., Schieber, M., Kocherginsky, M., Saleiro, D., & Platanias, L. C. (2024) · Blood Neoplasia · doi:10.1016/j.bneo.2024.100037 · Cited by 2

Bacterial Schlafens mediate anti-phage defensePreprint

Taboada, V. P., Wu, Y., Cassidy, R., Medvedev, K. E., Loeff, L., Nemudraia, A., & Nemudryi, A. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.24.666596 · Cited by 2

Optimized tDR Sequencing Reveals Diversity and Heterogeneity in tRNA-Derived Fragment Landscapes in Mouse Tissues

Ando, D., Rashad, S., & Niizuma, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188772 · Cited by 1

Co-expression of CD30 and SLFN11 serves as a dual biomarker for the treatment of cutaneous T-cell lymphoma

Shimauchi, T., Murai, J., Iwasaki, M., Phadungsaksawasdi, P., Ojima, T., Fujii, K., & Honda, T. (2025) · NAR Cancer · doi:10.1093/narcan/zcaf037 · Cited by 1

tRNA modifications in viral replication

Pathirage, C., Koutmou, K. S., & Musier‐Forsyth, K. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111430 · Cited by 1

Lost in translation: interferon-stimulated genes targeting flavivirus protein synthesis

Cannac, M., Zoladek, J., & Nisole, S. (2026) · Journal of Virology · doi:10.1128/jvi.00303-26 · Cited by 1

tDR-quant: a reliable electroporation-based approach for quantifying tRNA-derived fragments binding to ribosomes

Bąkowska-Żywicka, K., & Tyczewska, A. (2025) · FEMS Yeast Research · doi:10.1093/femsyr/foaf051 · Cited by 1

Recurrent Evolutionary Innovations in Rodent and Primate Schlafen Genes

Mordier, J., Fraisse, M., Cohen‐Tannoudji, M., & Molaro, A. (2025) · Genome Biology and Evolution · doi:10.1093/gbe/evaf172 · Cited by 3

Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a forkPreprint

Onji, H., Tate, S., Sakaue, T., Onishi, N., Matsumoto, T., Sugiyama, T., Higashiyama, S., & Murai, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.28.546820 · Cited by 1

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNAPreprint

Zhang, P., Hu, X., Li, Z., Liu, Q., Liu, L., Jin, Y., Liu, S., Zhao, X. H., Wang, J., Hao, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.24.581893 · Cited by 1

SLFN11 puts the brakes on Alternative lengthening of telomeresPreprint

Khandagale, P., Welter, A. L., Huang, S.-Y. N., Taniyama, D., Machida, Y., & Pommier, Y. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.08.692725 · Cited by 1

C1orf109L promote R-loop accumulation induced DNA damage to inhibit cell growthPreprint

Dou, P., Li, Y., Xie, W., Xiao-qing, Z., Zhang, D., Ci, Y., Xiaohan, Z., Shupei, Q., Akhtar, M. L., Han, F., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/625749

Schlafen14 Regulates Gene Expression Depending on Codon UsagePreprint

Valenzuela, C., Saucedo, S., & Llano, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.19.533350

Inhibiting XPOT suppresses TNBC growth via downregulating specific tRNA- TTC19 pathway mediating cytokinesis failurePreprint

Dai, H., Yang, X., Sheng, X., Wang, Y., Zhang, S., Zhang, X., Hu, L.-P., Zhang, Z., Dong, X., Yin, W., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2723400/v1

Data from SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

Murai, Y., Jo, U., Murai, J., Jenkins, L. M. M., Huang, S.-Y. N., Chakka, S., Chen, L., Cheng, K., Fukuda, S., Takebe, N., et al. (2023) · doi:10.1158/0008-5472.c.6513573.v1

SLFN11 Induces Apoptosis Through Ribosome Biogenesis ImpairmentPreprint

Murai, J., Ogawa, A., Isoyama, S., Izumikawa, K., Masaru, M., Watanabe, S., Jo, U., Taniyama, D., Kitajima, S., Fujiwara, K., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4831222 · Cited by 1

SLFN11 Deficiency-Induced Gemcitabine Resistance Is Overcome by Agents Targeting the DNA Damage Response in Pancreatic Cancer Cells

Kim, J. H., Youn, Y., & Hwang, J. (2025) · Biocell · doi:10.32604/biocell.2025.062144

Selective Biogenesis and Structural Diversity Shape tRNA-Derived Fragment Landscapes across Mouse OrgansPreprint

Ando, D., Rashad, S., & Niizuma, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.18.660468

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survivalPreprint

Nishimoto, Y., Yang, X., & Gregory, R. I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.19.660564

Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutationsPreprint

Ding, C., Liu, X. A., Zhang, F., Uematsu, S., Qian, S., & Xiang, Y. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703619

Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168Preprint

Jo, U., Taniyama, D., Pegoraro, G., Wu, Y., Huang, S.-Y., Thomas, C. J., Ozbun, L., Tran, A. D., Saha, L., Murai, J., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9297013/v1

SLFN-generated 3′-truncated tRNA Leu or tRNA Ser together with tRNase Z L works as a sequence-specific RNA cutterPreprint

Takahashi, M., & Nashimoto, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.12.718003

Type II tRNA cleavage by SLFN14 endoribonuclease variants linked to inherited thrombocytopenia drives global translational repression

Ding, C., Liu, X. A., Zhang, F., Uematsu, S., Qian, S., & Xiang, Y. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003830

Tetramerization and RNA-guided filament assembly control Schlafen–Argonaute antiphage defensePreprint

Kuzmenko, A., Radford, K., Oguienko, A. D., Lisitskaya, L., Gelfenbein, D. M., Chou, T., Kulbachinskiy, A. V., & Aravin, A. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728809

Alkylating agents activate an SLFN11-dependent vulnerability that confers PARP-1 inhibitor sensitivity in kidney cancer

Wang, C., Zhu, M., Bao, L., Tcheuyap, V. T., Brugarolas, J., Luo, W., & Wang, Y. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03743-1

The dual role of Schlafen11 in brain tumors: Jekyll and Hyde

Natsumeda, M., Okada, M., Nakata, S., Takahashi, H., Kakinuma, C., Lucas, C. G., Watanabe, J., Tsukamoto, Y., Eberhart, C. G., Kakita, A., et al. (2026) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2026.2695215

Mouse Schlafen Family Proteins Control MHV68 Replication in Fibroblasts

González, S., Lundquist, A. N., & Tucker, J. M. (2026) · Pathogens · doi:10.3390/pathogens15111099

Abstract 2573: DNA damaging drugs stimulate tRNA cleavage through SLFN11 to inhibit protein synthesis and induce cell death

Li, M., Kao, E., Malone, D., Gao, X., Wang, J. Y., & David, M. (2019) · Molecular and Cellular Biology / Genetics · doi:10.1158/1538-7445.sabcs18-2573

Human intrinsic immunity factor SLFN11 promotes cell death upon DNA damages through cleavage of distinct type II tRNAs and inhibition of proteins syntheses related to DNA damage responses and repairs

Li, M., Kao, E., Malone, D., Gao, X., Wang, J. Y. J., & David, M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.202.supp.194.20

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents

Iimori, Y., Morita, T., Masuda, T., Kitajima, S., Kono, N., Kageyama, S., Galipon, J., Sasaki, A. T., & Kanai, A. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf789 · Cited by 7

The Regulation and Activity of Schlafen11

Malone, D. (2017) · eScholarship (California Digital Library)

Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response

Malone, D., Lardelli, R. M., Li, M., & David, M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006588 · Cited by 43