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Cited by 141Nutrition and Health in AgingClinical Nutrition and GastroenterologyFrailty in Older Adults

Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients

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Hu, Xiaoyi, Zhang, Lei, Wang, Haozhong, Hao, Qiukui, Dong, Birong, Yang, Ming·2017·Scientific Reports
DOI 10.1038/s41598-017-03388-3PMC PMC5466644
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Abstract

A new term, malnutrition-sarcopenia syndrome (MSS), was recently coined to describe the clinical presentation of both malnutrition and sarcopenia. The aim of this study was to investigate the association between MSS and long-term mortality in older inpatients. We conducted a prospective study in acute geriatric wards of two local hospitals in China. Muscle mass and malnutrition were estimated by anthropometric measures and the Mini Nutritional Assessment (MNA). Of the 453 participants, 14 (3.1%) had sarcopenia with normal nutrition, 139 (30.7%) had malnutrition risk without sarcopenia, 48 (10.6%) had malnutrition risk with sarcopenia, 25 (5.5%) had malnutrition without sarcopenia, and 22 (4.9%) had MSS at baseline. Compared with non-sarcopenic subjects with normal nutrition, subjects with MSS and subjects with malnutrition risk and sarcopenia were more than four times more likely to die (hazard ratio [HR], 4.78; 95% confidence interval [CI], 2.09-10.97; and HR, 4.25; 95% CI, 2.22-8.12, respectively); non-sarcopenic subjects with malnutrition risk were more than two times more likely to die (HR, 2.41; 95% CI, 1.32-4.39). In conclusion, MSS may serve as a prognostic factor in the management of hospitalized older patients.

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  • Although MSS has not yet been widely evaluated in health settings, its potential value for predicting poor outcomes in clinical practices has been illustrated in several studies.

    “Although MSS has not yet been widely evaluated in health settings, its potential value for predicting poor outcomes in clinical practices has been illustrated in several studies (53, 54).”

    From Evolution of the diagnosis of malnutrition in adults: a primer for clinicians (2024) · cites this paper as [53]

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References 32 · Cited by 141

Research works printed but not linked: 28

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Authors
Hu, X., Zhang, L., Wang, H., Hao, Q., Dong, B., & Yang, M.
Affiliations
Sichuan University (CN)
Corresponding author
Yang, Ming
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-06-09
Volume
7
Issue
1
Pages
3171-3171
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-03388-3
PMC
PMC5466644
OpenAlex
W2621745073
Cited by
141
References
32
Citations by year
2026: 7 · 2025: 13 · 2024: 21 · 2023: 23 · 2022: 22 · 2021: 20 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 4
FWCI
7.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords
sarcopenia, malnutrition, mortality, hospitalized older adults, geriatric ward, prognostic factors, Mini Nutritional Assessment, muscle mass
MeSH terms
Aged, Aged, 80 and over, Anthropometry, China, Female, Humans, Male, Middle Aged, Hospital Mortality, Muscle, Skeletal, Malnutrition, Sarcopenia

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