The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona
Open accessAbstract
Studying the interactions of nanoparticles (NPs) with serum proteins is necessary for the rational development of nanocarriers. Optimum surface chemistry is a key consideration to modulate the formation of the serum protein corona (PC) and the resultant immune response. We investigated the constituent of the PC formed by hyaluronic acid-coated chitosan NPs (HA-CS NPs). Non-decorated chitosan NPs (CS NPs) and alginate-coated chitosan NPs (Alg-CS NPs) were utilized as controls. Results show that HA surface modifications significantly reduced protein adsorption relative to controls. Gene Ontology analysis demonstrates that HA-CS NPs were the least immunogenic nanocarriers. Indeed, less inflammatory proteins were adsorbed onto HA-CS NPs as opposed to CS and Alg-CS NPs. Interestingly, HA-CS NPs differentially adsorbed two unique anti-inflammatory proteins (ITIH4 and AGP), which were absent from the PC of both controls. On the other hand, CS and Alg-CS NPs selectively adsorbed a proinflammatory protein (Clusterin) that was not found on the surfaces of HA-CS NPs. While further studies are needed to investigate abilities of the PCs of only ITIH4 and AGP to modulate the interaction of NPs with the host immune system, our results suggest that this proof-of-concept could potentially be utilized to reduce the immunogenicity of a wide range of nanomaterials.
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Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
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Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740
Fischer, K., Kettunen, J., Würtz, P., Haller, T., Havulinna, A. S., Kangas, A. J., Soininen, P., Esko, T., Tammesoo, M.-L., Mägi, R., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001606 · Cited by 344
Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro
Xie, Z., Harris‐White, M. E., Wals, P. A., Frautschy, S. A., Finch, C. E., & Morgan, T. E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03065.x · Cited by 53
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Development and application of hyaluronic acid in tumor targeting drug delivery
Luo, Z., Dai, Y., & Gao, H. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.06.004 · Cited by 379
Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine
Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., & Chen, C. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02277 · Cited by 284
Advancing engineering design strategies for targeted cancer nanomedicine
Gomerdinger, V. F., Nabar, N., & Hammond, P. T. (2025) · Nature Reviews Cancer · doi:10.1038/s41568-025-00847-2 · Cited by 146
The impact of protein corona on the biological behavior of targeting nanomedicines
Farshbaf, M., Valizadeh, H., Panahi, Y., Fatahi, Y., Chen, M., Zarebkohan, A., & Gao, H. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121458 · Cited by 95
Metadata
- Authors
- Almalik, A., Benabdelkamel, H., Masood, A., Alanazi, I. O., Alradwan, I., Majrashi, M. A., Alfadda, A. A., Alghamdi, W. M., Alrabiah, H., Tirelli, N., & Alhasan, A. H.
- Venue
- Scientific Reports
- Published
- 2017-09-05
- Volume
- 7
- Issue
- 1
- Pages
- 10542-10542
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2752958725
- Cited by
- 195
- References
- 4
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Almalik, A., Benabdelkamel, H., Masood, A., Alanazi, I. O., Alradwan, I., Majrashi, M. A., Alfadda, A. A., Alghamdi, W. M., Alrabiah, H., Tirelli, N., & Alhasan, A. H. (2017). Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona. Scientific Reports. https://doi.org/10.1038/s41598-017-10836-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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