Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women
Open accessAbstract
Recent findings suggest an association between obesity, loss of gut barrier function and changes in microbiota profiles. Our primary objective was to examine the effect of caloric restriction and subsequent weight reduction on gut permeability in obese women. The impact on inflammatory markers and fecal microbiota was also investigated. The 4-week very-low calorie diet (VLCD, 800 kcal/day) induced a mean weight loss of 6.9 ± 1.9 kg accompanied by a reduction in HOMA-IR (Homeostasis model assessment-insulin resistance), fasting plasma glucose and insulin, plasma leptin, and leptin gene expression in subcutaneous adipose tissue. Plasma high-molecular weight adiponectin (HMW adiponectin) was significantly increased after VLCD. Plasma levels of high-sensitivity C-reactive protein (hsCRP) and lipopolysaccharide-binding protein (LBP) were significantly decreased after 28 days of VLCD. Using three different methods, gut paracellular permeability was decreased after VLCD. These changes in clinical parameters were not associated with major consistent changes in dominant bacterial communities in feces. In summary, a 4-week caloric restriction resulted in significant weight loss, improved gut barrier integrity and reduced systemic inflammation in obese women.
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Calorie restriction causes changes in microbiota composition, decreases inflammation, and improves gut barrier integrity.
“Consistent with the notion that changes in the gut microbiota composition can affect healthy ageing, calorie restriction — the most powerful strategy to increase longevity in animal models — causes changes in microbiota composition, decreases inflammation, and improves gut barrier integrity80.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [80]
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References 63 · Cited by 170
Research works printed but not linked: 1
- [35]Xiao S A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome FEMS microbiology ecology 2014 87 357 367 10.1111/1574-6941.12228 24117923 PMC4255291 · DOI
- Authors
- Ott, B., Skurk, T., Hastreiter, L., Lagkouvardos, I., Fischer, S., Büttner, J., Kellerer, T., Clavel, T., Rychlik, M., Haller, D., & Hauner, H.
- Affiliations
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Else Kröner Fresenius Zentrum für Ernährungsmedizin (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Universitätsklinikum Aachen (DE)
- Technical University of Munich (DE)
- TUM Klinikum (DE)
- Corresponding author
- Hauner, Hans
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-09-20
- Volume
- 7
- Issue
- 1
- Pages
- 11955-11955
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5607294
- OpenAlex
- W2753985003
- Cited by
- 170
- References
- 63
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 22 · 2023: 18 · 2022: 24 · 2021: 17 · 2020: 28 · 2019: 19 · 2018: 13
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion, cc-by)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- RWTH Publications (RWTH Aachen)
- Funders
- Bundesministerium für Bildung und Forschung (0315674)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- caloric restriction, very low calorie diet, obesity, intestinal permeability, intestinal barrier, fecal microbiota, systemic inflammation, insulin resistance, leptin, adiponectin, C-reactive protein, lipopolysaccharide-binding protein, weight loss, women
- MeSH terms
- Gastrointestinal Microbiome, Adult, Blood Chemical Analysis, Feces, Female, Humans, Inflammation, Middle Aged, Obesity, Permeability, Treatment Outcome, Caloric Restriction, Gastrointestinal Tract, Microbiota
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