Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
Open accessAbstract
Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice. This was, at least partly, attributable to alliin induced modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae. From above, we conclude that alliin has nutraceutical or even medicinal potential in prevention of diabetes and lipid metabolic disorders.
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Alliin extracted from garlic decreases the abundance of f_Lachnospiraceae.
“alliin extracted from garlic was found to decrease the abundance of f_Lachnospiraceae [56].”
From Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis (2019) · cites this paper as [56]
The activity of alliin in reducing diabetes mellitus in rats was similar to that demonstrated by glibenclamide and insulin.
“Zhai et al. [115] reported that the activity of alliin in reducing diabetes mellitus in rats was similar to that demonstrated by glibenclamide and insulin.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [115]
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References 44 · Cited by 123
Research works printed but not linked: 6
- [6]Lawson LD Garlic: a review of its medicinal effects and indicated active compounds Acs National Meeting Book of Abstracts 1998 691 176 209
- [8]Kodera, Y., Matsuura, H., Sumiyoshi, H. & Sumi, S.-i. In ACS Symposium Series. 346–357.
- [11]Saravanan G Ponmurugan P Rajarajan T Antidiabetic properties of S-allyl cysteine, a garlic component on streptozotocin-induced diabetes in rats Journal of Applied Biomedicine 2009 7 151 159
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- Authors
- Zhai, B., Zhang, C., Sheng, Y., Zhao, C., He, X., Xu, W., Huang, K., & Luo, Y.
- Affiliations
- Beijing Advanced Innovation Center for Food Nutrition and Human Health (CN)
- Jilin University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Corresponding author
- Luo, Yunbo
- Venue
- Scientific Reports
- Published
- 2018-02-23
- Volume
- 8
- Issue
- 1
- Pages
- 3527-3527
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5824805
- OpenAlex
- W2801785722
- Cited by
- 123
- References
- 44
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 14 · 2023: 12 · 2022: 23 · 2021: 22 · 2020: 18 · 2019: 10 · 2018: 2
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81700684)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- alliin, diet-induced obesity, glucose homeostasis, insulin sensitivity, hypolipidemic effect, lipid profile, gut microbiota, Lachnospiraceae, Ruminococcaceae, nutraceuticals, diabetes prevention, metabolic risk factors
- MeSH terms
- Eubacteriales, Clostridiales, Gastrointestinal Microbiome, Administration, Oral, Animals, Hypolipidemic Agents, Body Composition, Body Weight, Cysteine, Energy Metabolism, Glucose, Glucose Tolerance Test, Homeostasis, Hyperlipidemias, Hypoglycemic Agents, Insulin, Insulin Resistance, Liver, Male, Mice, Inbred C57BL, Obesity, Subcutaneous Fat, Mice, Diet, High-Fat, Drinking Water
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