The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota
Open accessAbstract
Type 2 diabetes mellitus (T2DM), a chronic metabolic disease which severely impairs peoples’ quality of life, currently attracted worldwide concerns. There are growing evidences that gut microbiota can exert a great impact on the development of T2DM. Xiexin Tang (XXT), a traditional Chinese medicine prescription, has been clinically used to treat diabetes for thousands of years. However, few researches are investigated on the modulation of gut microbiota community by XXT which will be very helpful to unravel how it works. In this study, bacterial communities were analyzed based on high-throughput 16S rRNA gene sequencing. Results indicated that XXT could notably shape the gut microbiota. T2DM rats treated with XXT exhibited obvious changes in the composition of the gut microbiota, especially for some short chain fatty acids producing and anti-inflammatory bacteria such as Adlercreutzia, Alloprevotella, Barnesiella, [Eubacterium] Ventriosum group, Blautia, Lachnospiraceae UCG-001, Papillibacter and Prevotellaceae NK3B31 group. Additionally, XXT could also significantly ameliorate hyperglycemia, lipid metabolism dysfunction and inflammation in T2DM rats. Moreover, the correlation analysis illustrated that the key microbiota had a close relationship with the T2DM related indexes. The results probably provided useful information for further investigation on its active mechanism and clinical application.
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Cited by
Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines
Feng, W., Ao, H., & Peng, C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01354 · Cited by 367
The mechanism of berberine alleviating metabolic disorder based on gut microbiome
Wang, H., Zhang, H., Gao, Z., Zhang, Q., & Gu, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854885 · Cited by 69
Metadata
- Authors
- Wei, X., Tao, J., Xiao, S., Jiang, S., Shang, E., Zhu, Z., Qian, D., & Duan, J.
- Venue
- Scientific Reports
- Published
- 2018-02-27
- Volume
- 8
- Issue
- 1
- Pages
- 3685-3685
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2806350604
- Cited by
- 256
- References
- 68
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wei, X., Tao, J., Xiao, S., Jiang, S., Shang, E., Zhu, Z., Qian, D., & Duan, J. (2018). Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota. Scientific Reports. https://doi.org/10.1038/s41598-018-22094-2
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