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Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats
Open accessAbstract
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by the production of antibodies against acetylcholine receptors (AChRs). Qiangji Jianli (QJJL) decoction is an effective traditional Chinese medicine (TCM) that is used to treat MG. Our study aimed to investigate the effect of QJJL decoction on MG and to clarify the mechanism by which QJJL regulates mitochondrial energy metabolism and mitochondrial fusion and fission (MFF). SPF female Lewis rats were administered Rat 97–116 peptides to induce experimental autoimmune myasthenia gravis (EAMG). The treatment groups received QJJL decoction (7.8 g/kg, 15.6 g/kg and 23.4 g/kg). Mitochondria were extracted from gastrocnemius tissue samples to detect respiratory chain complex enzymatic activity. Quantitative PCR and western blot analysis were performed to detect Mfn1/2, Opa1, Drp1 and Fis1 mRNA and protein expression, respectively, in the mitochondria. Transmission electron microscopy examination was performed to show the improvement of mitochondria and myofibrils after QJJL treatment. The results indicated that QJJL decoction may attenuate MG by promoting the enzymatic activity of respiratory chain complexes to improve energy metabolism. Moreover, QJJL decoction increased Mfn1/2, Opa1, Drp1 and Fis1 mRNA and protein expression to exert its curative effect on MFF. Thus, QJJL decoction may be a promising therapy for MG.
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“Muscle loss in aging sarcopenia [185, 187, 215], cancer cachexia, chemotherapy-induced cachexia [157–159], and in a model of myasthenia gravis [216], is characterized by the decline of both fusion and fission machinery.”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [216]
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“However, muscle loss in aging sarcopenia, cancer cachexia, and myasthenia gravis are characterized by the decline of both fusion machinery and fission machinery [6,11,12,15,16,17,18].”
From Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles (2019) · cites this paper as [18]
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Metadata
- Authors
- Song, J., Lei, X., Jiao, W., Song, Y., Chen, W., Li, J., & Chen, Z.
- Affiliations
- Guangzhou University of Chinese Medicine (CN)
- Corresponding author
- Song, Yafang
- Venue
- Scientific Reports
- Published
- 2018-06-05
- Volume
- 8
- Issue
- 1
- Pages
- 8623-8623
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5988663
- OpenAlex
- W2805869944
- Cited by
- 28
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (XH20160106, 81473568)
- Guangzhou University of Chinese Medicine (XH 20160106, 81473568)
- Guangzhou University
- Environment Building for Science and Technology Industries
- Topics
- Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myasthenia gravis, traditional Chinese medicine, mitochondrial fission and fusion, mitochondrial respiratory chain, mitochondrial bioenergetics, OPA1, Drp1, Fis1, experimental autoimmune myasthenia gravis, gastrocnemius, acetylcholine receptor antibodies
- MeSH terms
- Animals, Disease Models, Animal, Electron Transport, Energy Metabolism, Mitochondria, Myasthenia Gravis, Plant Extracts, Plants, Medicinal, Rats, Inbred Lew, Gene Expression, Treatment Outcome, Gene Expression Profiling, Mitochondrial Proteins, Real-Time Polymerase Chain Reaction, Mitochondrial Dynamics
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