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Cited by 29Liver Diseases and ImmunityHepatitis B Virus StudiesHepatitis Viruses Studies and Epidemiology

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Increased seroprevalence of HAV and parvovirus B19 in children and of HEV in adults at diagnosis of autoimmune hepatitis

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Taubert, Richard, Diestelhorst, Jana, Junge, Norman, Kirstein, Martha M., Pischke, Sven, Vogel, Arndt, Bantel, Heike, Baumann, Ulrich, Manns, Michael P., Wedemeyer, Heiner, Jaeckel, Elmar·2018·Scientific Reports
DOI 10.1038/s41598-018-35882-7PMC PMC6261942
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Abstract

Preceding viral infections have mostly been described in autoimmune hepatitis (AIH) in single cases. We aimed to identify viral infections that potentially trigger AIH, as suggested for hepatitis E virus (HEV) infections. Therefore, antibodies against hepatitis A (HAV), B, C and E viruses; hepatotropic herpesviruses; and parvovirus B19 (PVB19) were analyzed retrospectively in 219 AIH patients at diagnosis, 356 patients with other liver diseases and 89 children from our center. Untreated adult AIH (aAIH) patients showed higher anti-HEV seroprevalences at diagnosis than patients with other liver diseases. Untreated aAIH patients had no increased incidence of previous hepatitis A, B or C. Antibodies against hepatotropic herpesviruses in untreated AIH were in the range published for the normal population. Untreated pediatric AIH (pAIH) patients had evidence of more previous HAV and PVB19 infections than local age-matched controls. The genetic AIH risk factor HLA DRB1*03:01 was more frequent in younger patients, and DRB1*04:01 was more frequent in middle-aged patients without an obvious link to virus seropositivities. Pediatric and adult AIH seem to be distinct in terms of genetic risk factors and preceding viral infections. While associations cannot prove causal relations, the results suggest that hepatotropic virus infections could be involved in AIH pathogenesis.

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Research works printed but not linked: 42

  1. Gronbaek, L., Vilstrup, H. & Jepsen, P. Autoimmune hepatitis in Denmark: incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study. Journal of hepatology 60, 612–617, https://doi.org/10.1016/j.jhep.2013.10.020 (2014). · DOI
  2. Hardtke-Wolenski, M. et al. Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells. Hepatology 58, 718–728, https://doi.org/10.1002/hep.26380 (2013). · DOI
  3. Holdener, M. et al. Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection. J Exp Med 205, 1409–1422, https://doi.org/10.1084/jem.20071859 (2008). · DOI
  4. Lapierre, P., Djilali-Saiah, I., Vitozzi, S. & Alvarez, F. A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens. Hepatology 39, 1066–1074, https://doi.org/10.1002/hep.20109 (2004). · DOI
  5. Webb, G. J., Hirschfield, G. M., Krawitt, E. L. & Gershwin, M. E. Cellular and Molecular Mechanisms of Autoimmune Hepatitis. Annual review of pathology, https://doi.org/10.1146/annurev-pathol-020117-043534 (2017). · DOI
  6. Manns, M. P. Hepatotropic viruses and autoimmunity 1997. J Viral Hepat 4(Suppl 1), 7–10 (1997). · DOI
  7. Singh, G., Palaniappan, S., Rotimi, O. & Hamlin, P. J. Autoimmune hepatitis triggered by hepatitis A. Gut 56, 304, https://doi.org/10.1136/gut.2006.111864 (2007). · DOI
  8. Vento, S. et al. Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals. Lancet 346, 608–609 (1995). · DOI
  9. Gregorio, G. V., Bracken, P., Mieli-Vergani, G. & Vergani, D. Prevalence of antibodies to hepatitis C and herpes simplex virus type 1 is not increased in children with liver kidney microsomal type 1 autoimmune hepatitis. J Pediatr Gastroenterol Nutr 23, 534–537 (1996). · DOI
  10. Pischke, S. et al. Increased HEV seroprevalence in patients with autoimmune hepatitis. PloS one 9, e85330, https://doi.org/10.1371/journal.pone.0085330 (2014). · DOI
  11. van Gerven, N. M. et al. Seroprevalence of Hepatitis E Virus in Autoimmune Hepatitis Patients in the Netherlands. J Gastrointestin Liver Dis 25, 9–13, https://doi.org/10.15403/jgld.2014.1121.251.hpe (2016). · DOI
  12. Poethko-Muller, C. & Schmitz, R. Vaccination coverage in German adults: results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56, 845–857, https://doi.org/10.1007/s00103-013-1693-6 (2013). · DOI
  13. Poethko-Muller, C. et al. Epidemiology of hepatitis A, B, and C among adults in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56, 707–715, https://doi.org/10.1007/s00103-013-1673-x (2013). · DOI
  14. Kurth, B. M. et al. The challenge of comprehensively mapping children’s health in a nation-wide health survey: design of the German KiGGS-Study. BMC public health 8, 196, https://doi.org/10.1186/1471-2458-8-196 (2008). · DOI
  15. Martro, E. et al. Comparison of human herpesvirus 8 and Epstein-Barr virus seropositivity among children in areas endemic and non-endemic for Kaposi’s sarcoma. J Med Virol 72, 126–131, https://doi.org/10.1002/jmv.10548 (2004). · DOI
  16. Morris, M. C. et al. Sero-epidemiological patterns of Epstein-Barr and herpes simplex (HSV-1 and HSV-2) viruses in England and Wales. J Med Virol 67, 522–527, https://doi.org/10.1002/jmv.10132 (2002). · DOI
  17. Rohrer, C. et al. Seroprevalence of parvovirus B19 in the German population. Epidemiol Infect 136, 1564–1575, https://doi.org/10.1017/S0950268807009958 (2008). · DOI
  18. Sauerbrei, A. et al. Seroprevalence of herpes simplex virus type 1 and type 2 in Thuringia, Germany, 1999 to 2006. Euro Surveill 16 (2011). · DOI
  19. Voigt, S., Schaffrath Rosario, A. & Mankertz, A. Cytomegalovirus Seroprevalence Among Children and Adolescents in Germany: Data From the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), 2003–2006. Open Forum Infect Dis 3, ofv193, https://doi.org/10.1093/ofid/ofv193 (2016). · DOI
  20. Wiersbitzky, S. et al. Seroprevalence of antibodies to human herpesvirus 6 (exanthema subitum; critical 3-day fever-exanthema in young children) in the population of Northern Germany. Kinderarztl Prax 59, 170–173 (1991).
  21. Wutzler, P., Farber, I., Wagenpfeil, S., Bisanz, H. & Tischer, A. Seroprevalence of varicella-zoster virus in the German population. Vaccine 20, 121–124 (2001). · DOI
  22. Just-Nubling, G. et al. Primary cytomegalovirus infection in an outpatient setting–laboratory markers and clinical aspects. Infection 31, 318–323, https://doi.org/10.1007/s15010-003-3129-y (2003). · DOI
  23. Hellenbrand, W., Thierfelder, W., Muller-Pebody, B., Hamouda, O. & Breuer, T. Seroprevalence of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in former East and West Germany, 1997-1998. European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology 24, 131–135, https://doi.org/10.1007/s10096-005-1286-x (2005). · DOI
  24. Weissbrich, B., Suss-Frohlich, Y. & Girschick, H. J. Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis. Arthritis Res Ther 9, R82, https://doi.org/10.1186/ar2281 (2007). · DOI
  25. Junge, N. et al. Human leucocyte antigens and pediatric autoimmune liver disease: diagnosis and prognosis. Eur J Pediatr 175, 527–537, https://doi.org/10.1007/s00431-015-2662-x (2016). · DOI
  26. Kirstein, M. M. et al. Prediction of short- and long-term outcome in patients with autoimmune hepatitis. Hepatology, https://doi.org/10.1002/hep.27983 (2015). · DOI · Paper page
  27. Pischke, S. et al. Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients. Clin Infect Dis 63, 569–570, https://doi.org/10.1093/cid/ciw309 (2016). · DOI
  28. Eder, M. et al. High seroprevalence of hepatitis E in patients with autoimmune hepatitis. Journal of hepatology 62 (2015). · DOI
  29. Krumbholz, A. et al. Seroprevalence of hepatitis E virus (HEV) in humans living in high pig density areas of Germany. Med Microbiol Immunol 203, 273–282, https://doi.org/10.1007/s00430-014-0336-3 (2014). · DOI
  30. Kamar, N., Marion, O., Abravanel, F., Izopet, J. & Dalton, H. R. Extrahepatic manifestations of hepatitis E virus. Liver international: official journal of the International Association for the Study of the Liver 36, 467–472, https://doi.org/10.1111/liv.13037 (2016). · DOI
  31. Terziroli Beretta-Piccoli, B. et al. Autoimmune liver disease serology in acute hepatitis E virus infection. Journal of autoimmunity, https://doi.org/10.1016/j.jaut.2018.07.006 (2018). · DOI
  32. Le Cann, P., Tong, M. J., Werneke, J. & Coursaget, P. Detection of antibodies to hepatitis E virus in patients with autoimmune chronic active hepatitis and primary biliary cirrhosis. Scand J Gastroenterol 32, 387–389 (1997). · DOI
  33. Sylvan, S. P., Hellstrom, U. B., Hampl, H., Kapprell, H. P. & Troonen, H. Hepatitis E in patients with chronic autoimmune liver disease. JAMA 273, 377–378 (1995). · DOI
  34. Vergani, D., Mieli-Vergani, G., Mondelli, M., Portmann, B. & Eddleston, A. L. Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage. Liver 7, 307–315 (1987). · DOI
  35. Fainboim, L. et al. Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB*1301, a marker for pediatric autoimmune hepatitis. Hepatology 33, 1512–1517, https://doi.org/10.1053/jhep.2001.24562 (2001). · DOI
  36. Kerr, J. R. The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease. Journal of clinical pathology 69, 279–291, https://doi.org/10.1136/jclinpath-2015-203455 (2016). · DOI
  37. Oliveira, L. C. et al. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmunity reviews 10, 189–193, https://doi.org/10.1016/j.autrev.2010.09.024 (2011). · DOI
  38. Hyoty, H. et al. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 44, 652–657 (1995). · DOI
  39. Selin, L. K. et al. Heterologous immunity: immunopathology, autoimmunity and protection during viral infections. Autoimmunity 44, 328–347, https://doi.org/10.3109/08916934.2011.523277 (2011). · DOI
  40. Bouziat, R. et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 356, 44–50, https://doi.org/10.1126/science.aah5298 (2017). · DOI
  41. Alvarez, F. et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. Journal of hepatology 31, 929–938 (1999). · DOI · Paper page
  42. Scheidt-Nave, C. et al. German health interview and examination survey for adults (DEGS) - design, objectives and implementation of the first data collection wave. BMC public health 12, 730, https://doi.org/10.1186/1471-2458-12-730 (2012). · DOI

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Metadata

Authors
Taubert, R., Diestelhorst, J., Junge, N., Kirstein, M. M., Pischke, S., Vogel, A., Bantel, H., Baumann, U., Manns, M. P., Wedemeyer, H., & Jaeckel, E.
Affiliations
Medizinische Hochschule Hannover (DE)
Corresponding author
Taubert, Richard
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-11-28
Volume
8
Issue
1
Pages
17452-17452
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-018-35882-7
PMC
PMC6261942
OpenAlex
W2901650687
Cited by
29
References
1
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 7
FWCI
3.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Medizinischen Hochschule Hannover (Young Faculty Program)
  • Deutsche Forschungsgemeinschaft (KFO250 Project 7)
  • Else Kröner-Fresenius-Stiftng: klinStrucMed Program
Topics
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
Keywords
autoimmune hepatitis, hepatitis A virus, parvovirus B19, hepatitis E virus, seroprevalence, pediatric autoimmune hepatitis, HLA-DRB1, HLA-DRB1*0301, HLA-DRB1*0401, hepatitis B, hepatitis C, hepatitis E, autoimmune disease pathogenesis
MeSH terms
Adolescent, Adult, Aged, Antibodies, Viral, Autoantibodies, Child, Child, Preschool, Disease Susceptibility, Female, Hepatitis A, Humans, Immunoglobulin G, Infant, Infant, Newborn, Male, Middle Aged, Parvoviridae Infections, Risk Factors, Biomarkers, Prevalence, Seroepidemiologic Studies, Parvovirus B19, Human, Hepatitis E, Hepatitis E virus, Age Distribution, Hepatitis A Virus, Human, Hepatitis, Autoimmune, Genetic Predisposition to Disease, Young Adult

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