New screening approach for Alzheimer’s disease risk assessment from urine lipid peroxidation compounds
Open accessAbstract
Alzheimer Disease (AD) standard biological diagnosis is based on expensive or invasive procedures. Recent research has focused on some molecular mechanisms involved since early AD stages, such as lipid peroxidation. Therefore, a non-invasive screening approach based on new lipid peroxidation compounds determination would be very useful. Well-defined early AD patients and healthy participants were recruited. Lipid peroxidation compounds were determined in urine using a validated analytical method based on liquid chromatography coupled to tandem mass spectrometry. Statistical studies consisted of the evaluation of two different linear (Elastic Net) and non-linear (Random Forest) regression models to discriminate between groups of participants. The regression models fitted to the data from some lipid peroxidation biomarkers (isoprostanes, neuroprostanes, prostaglandines, dihomo-isoprostanes) in urine as potential predictors of early AD. These prediction models achieved fair validated area under the receiver operating characteristics (AUC-ROCs > 0.68) and their results corroborated each other since they are based on different analytical principles. A satisfactory early screening approach, using two complementary regression models, has been obtained from urine levels of some lipid peroxidation compounds, indicating the individual probability of suffering from early AD.
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Oxidative damage products are detected in body fluids such as blood, plasma, serum, cerebrospinal fluid, urine, and saliva.
“They are detected in body fluids such as blood, plasma, serum, cerebrospinal fluid (CSF), urine, and saliva [25,26,27].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [25]
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References 37 · Cited by 28
- Authors
- Peña-Bautista, C., Vigor, C., Galano, J.-M., Oger, C., Durand, T., Ferrer, I., Cuevas, A., López-Cuevas, R., Baquero, M., López-Nogueroles, M., Vento, M., Hervás-Marín, D., García-Blanco, A., & Cháfer-Pericás, C.
- Affiliations
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Hospital Universitari i Politècnic La Fe (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
- ORCID
- Venue
- Scientific Reports
- Published
- 2019-10-02
- Volume
- 9
- Issue
- 1
- Pages
- 14244-14244
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6775072
- OpenAlex
- W2978458696
- Cited by
- 28
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 6
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España (CP16/00082)
- Instituto de Salud Carlos III (CP16/00082, JR17/00003)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- Alzheimer's disease, early diagnosis, non-invasive screening, lipid peroxidation, urinary biomarkers, isoprostanes, neuroprostanes, elastic net, random forest
- MeSH terms
- Aged, Alzheimer Disease, Chromatography, Liquid, Female, Humans, Male, Middle Aged, Neuropsychological Tests, ROC Curve, Lipid Peroxidation, Biomarkers, Eicosanoids, Linear Models, Risk Assessment, Area Under Curve, Early Diagnosis, Tandem Mass Spectrometry, Neuroimaging
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