Functional neuroanatomy of interoceptive processing in children and adolescents: a pilot study
Open accessAbstract
In adults, interoception - the sense of the physiological condition of the body - appears to influence emotion processing, cognition, behavior and various somatic and mental health disorders. Adults demonstrate frontal-insula-parietal-anterior cingulate cortex activation during the heartbeat detection task, a common interoceptive measure. Little, however, is known about the functional neuroanatomy underlying interoception in children. The current pilot study examined interoceptive processing in children and adolescents with fMRI while using the heartbeat detection task. Our main findings demonstrate that children as young as the age of six activate the left insula, cuneus, inferior parietal lobule and prefrontal regions. These findings are similar to those in adults when comparing heartbeat and tone detection conditions. Age was associated with increased activation within the dACC, orbital frontal cortex and the mid-inferior frontal gyri. Thus, our pilot study may provide important information about the neurodevelopment of interoceptive processing abilities in children and a task for future interoception neuroimaging studies in children.
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6-17 year olds activate similar neural substrates to adults while performing the heartbeat counting task.
“6−17 year olds have been found to activate similar neural substrates to adults while performing the heartbeat counting task, such as the insula, medial prefrontal cortex and inferior parietal lobule (Klabunde et al., 2019).”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Klabunde et al., 2019
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References 47 · Cited by 29
- Authors
- Klabunde, M., Juszczak, H., Jordan, T., Baker, J. M., Bruno, J., Carrion, V., & Reiss, A. L.
- Affiliations
- University of Essex (GB)
- University of California San Francisco Medical Center (US)
- Stanford Medicine (US)
- Corresponding author
- Klabunde, M.
- Venue
- Scientific Reports
- Published
- 2019-11-07
- Volume
- 9
- Issue
- 1
- Pages
- 16184-16184
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6838093
- OpenAlex
- W2986861052
- Cited by
- 29
- References
- 47
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 2
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open Access at Essex (University of Essex) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (T32MH019908)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- interoception, heartbeat detection, children, adolescents, brain development, insula, anterior cingulate cortex, prefrontal cortex, inferior parietal lobule, cuneus, age differences
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebral Cortex, Child, Female, Humans, Magnetic Resonance Imaging, Male, Pilot Projects, Interoception
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