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Cited by 45Wound Healing and TreatmentsMollusks and Parasites StudiesPhytochemistry and biological activity of medicinal plants

Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies

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EL-Zawawy, Nessma A., Mona, Mahy M.·2021·Scientific Reports
DOI 10.1038/s41598-021-03664-3PMC PMC8692597
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Abstract

Snail mucus is composed of bioactive compounds thought to have different biological properties for the treatment of some skin problems. Although Helix aspersa mucus is used in several cosmetic products, a detailed characterization of Eremina desertorum mucus composition and its biological activities is still missing. Mucus extracts (MEs) from H. aspersa and E. desertorum were prepared and tested for their antimicrobial and anti-inflammatory activities with their potencies in wound healing. Also, chemical characterization was performed by GC–MS analysis. Results showed that ME of E. desertorum gave higher inhibitory activity against resistant strains related to burn wound infections compared to ME of H. aspersa. Additionally, it revealed a significant anti-inflammatory activity. Moreover, we found that ME of E. desertorum lacked cytotoxicity and was able to significantly induce cell proliferation and migration through up-regulation of TGF-β1 and VEGF gene expression. Our results suggested that MEs of E. desertorum have higher biological effects than H. aspersa, which are attributable to antimicrobial, anti-inflammatory activities, cell proliferation and pave the way for further investigating its potential effect as a human therapeutic agent.

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Sorted by citations

Authors
EL-Zawawy, N. A., & Mona, M. M.
Affiliations
Tanta University (EG)
Corresponding author
EL-Zawawy, Nessma A.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-12-21
Volume
11
Issue
1
Pages
24317-24317
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-021-03664-3
PMC
PMC8692597
OpenAlex
W4200334538
Cited by
45
References
1
Citations by year
2026: 6 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 4
FWCI
3.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
Keywords
Helix aspersa, snail mucus, antimicrobial activity, anti-inflammatory activity, wound healing, burn wound infection, cytotoxicity, cell proliferation, cell migration, TGF-β1, vascular endothelial growth factor
MeSH terms
Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Bacteria, Helix, Snails, Humans, Mucus, Skin, Tissue Extracts, Wound Healing

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