Symptoms of anxiety/depression is associated with more aggressive inflammatory bowel disease
Open accessAbstract
Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impact of anxiety/depression on Chinese IBD patients. The aim of this study was to find out the prevalence of symptoms of anxiety/depression in Chinese IBD population and its impact on IBD-related features. This is a cross-sectional study from the southwest China IBD referral center. Eligible participants were divided into those with symptoms of anxiety/depression and those without based on the Hospital Anxiety and Depression Scale (HADS). Demographic data and disease duration, IBD-related surgery, tobacco use, extra-intestinal manifestations, disease activity scores, endoscopic evaluation, laboratory data and current medication use were compared between two groups. A total of 341 IBD patients [221 Crohn’s disease (CD) and 120 ulcerative colitis (UC)] were included. The prevalence of symptoms of anxiety/depression in IBD was 33.1%. CD patients with symptoms of anxiety/depression tended to have higher scores of simple endoscopic scores for Crohn’s disease (SES-CD) (p = 0.0005). UC patients with symptoms of anxiety/depression had a significantly higher Mayo score (p = 0.0017) and ulcerative colitis endoscopic index of severity (UCEIS) (p < 0.0001) than their non-anxiety/depression counterparts. CD-related surgery (p = 0.012) and Crohn's disease activity index (CDAI) (p < 0.0001) were identified as independent risk factors for symptoms of anxiety/depression in CD, while corticosteroid use (p = 0.036) as an independent risk factor for symptoms of anxiety/depression in UC. This study helps our understanding of the prevalence of symptoms of anxiety/depression in IBD patients and its impact on IBD course and reminds us to pay more attention on IBD management with anxiety/depression.
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Individuals with IBD are at increased risk of experiencing poor psychological wellbeing.
“research findings highlight that individuals with IBD are also at increased risk of experiencing poor psychological wellbeing (Gao et al., 2021; Mikocka-Walus et al., 2016).”
From Moving Towards Acceptance and Values: A Qualitative Study of ACTforIBD Compared to IBD Psychoeducation (2024) · cites this paper as Gao et al., 2021
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References 32 · Cited by 84
- Authors
- Gao, X., Tang, Y., Lei, N., Luo, Y., Chen, P., Liang, C., Duan, S., & Zhang, Y.
- Affiliations
- West China Hospital of Sichuan University (CN)
- Corresponding author
- Zhang, Yan
- Venue
- Scientific Reports
- Published
- 2021-01-14
- Volume
- 11
- Issue
- 1
- Pages
- 1440-1440
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7809475
- OpenAlex
- W3125950663
- Cited by
- 84
- References
- 32
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 14 · 2023: 20 · 2022: 21 · 2021: 5
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (88170550)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, anxiety, depression, Crohn's disease, ulcerative colitis, disease severity, endoscopic severity, disease activity, corticosteroid use, Chinese patients, prevalence, risk factors
- MeSH terms
- Adolescent, Adult, Aged, Anxiety, Colitis, Ulcerative, Crohn Disease, Cross-Sectional Studies, Depression, Female, Humans, Male, Middle Aged, Severity of Illness Index, Prevalence
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