ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer
Open accessAbstract
The infiltration degree of immune and stromal cells has been shown clinically significant in tumor microenvironment (TME). However, the utility of stromal and immune components in Gastric cancer (GC) has not been investigated in detail. In the present study, ESTIMATE and CIBERSORT algorithms were applied to calculate the immune/stromal scores and the proportion of tumor-infiltrating immune cell (TIC) in GC cohort, including 415 cases from The Cancer Genome Atlas (TCGA) database. The differentially expressed genes (DEGs) were screened by Cox proportional hazard regression analysis and protein–protein interaction (PPI) network construction. Then ADAMTS12 was regarded as one of the most predictive factors. Further analysis showed that ADAMTS12 expression was significantly higher in tumor samples and correlated with poor prognosis. Gene Set Enrichment Analysis (GSEA) indicated that in high ADAMTS12 expression group gene sets were mainly enriched in cancer and immune-related activities. In the low ADAMTS12 expression group, the genes were enriched in the oxidative phosphorylation pathway. CIBERSORT analysis for the proportion of TICs revealed that ADAMTS12 expression was positively correlated with Macrophages M0/M1/M2 and negatively correlated with T cells follicular helper. Therefore, ADAMTS12 might be a tumor promoter and responsible for TME status and tumor energy metabolic conversion.
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Patients with gastric cancer with high expression of ADAMTS12 had an unfavourable prognosis, and the content of M0 macrophages was also increased.
“Wu et al. have recently reported that patients with gastric cancer with high expression of ADAMTS12 had an unfavourable prognosis, and interestingly, the content of M0 macrophages was also increased [36].”
From Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells (2022) · cites this paper as [36]
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References 57 · Cited by 19
- Authors
- Hou, Y., Xu, Y., & Wu, D.
- Affiliations
- Second Affiliated Hospital of Harbin Medical University (CN)
- Jilin University (CN)
- Harbin Medical University (CN)
- Corresponding author
- Wu, Dequan
- Venue
- Scientific Reports
- Published
- 2021-05-26
- Volume
- 11
- Issue
- 1
- Pages
- 10996-10996
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC8154915
- OpenAlex
- W3165516637
- Cited by
- 19
- References
- 57
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 7 · 2022: 5
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Scientific Research Innovation Project of Harbin Medical University (YJSKYCX2019-50HYD)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- ADAMTS12, gastric cancer, tumor microenvironment, tumor-infiltrating immune cells, tumor stroma, prognostic factors, macrophage polarization, T follicular helper cells, oxidative phosphorylation, tumor energy metabolism
- MeSH terms
- ADAMTS Proteins, Female, Humans, Male, Middle Aged, Prognosis, Stomach Neoplasms, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Gene Expression Profiling, Tumor Microenvironment, Protein Interaction Maps
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