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Cited by 17Berberine and alkaloids researchBirth, Development, and HealthGestational Diabetes Research and Management

Berberine elevates cardiolipin in heart of offspring from mouse dams with high fat diet-induced gestational diabetes mellitus

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Cole, Laura K., Sparagna, Genevieve C., Vandel, Marilyne, Xiang, Bo, Dolinsky, Vernon W., Hatch, Grant M.·2021·Scientific Reports
DOI 10.1038/s41598-021-95353-4PMC PMC8338981
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Abstract

Berberine (BBR) is an isoquinoline alkaloid from plants known to improve cardiac mitochondrial function in gestational diabetes mellitus (GDM) offspring but the mechanism is poorly understood. We examined the role of the mitochondrial phospholipid cardiolipin (CL) in mediating this cardiac improvement. C57BL/6 female mice were fed either a Lean-inducing low-fat diet or a GDM-inducing high-fat diet for 6 weeks prior to breeding. Lean and GDM-exposed male offspring were randomly assigned a low-fat, high-fat, or high-fat diet containing BBR at weaning for 12 weeks. The content of CL was elevated in the heart of GDM offspring fed a high fat diet containing BBR. The increase in total cardiac CL was due to significant increases in the most abundant and functionally important CL species, tetralinoleoyl-CL and this correlated with an increase in the expression of the CL remodeling enzyme tafazzin. Additionally, BBR treatment increased expression of cardiac enzymes involved in fatty acid uptake and oxidation and electron transport chain subunits in high fat diet fed GDM offspring. Thus, dietary BBR protection from cardiac dysfunction in GDM exposed offspring involves improvement in mitochondrial function mediated through increased synthesis of CL.

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  • Maternal administration of natural compounds could also protect offspring from cardiovascular dysfunction through direct effects on the heart or by mitigating GDM-induced obesity or other cardiometabolic conditions.

    “Therefore, maternal administration of natural compounds could also protect offspring from cardiovascular dysfunction through direct effects on the heart or by mitigating GDM-induced obesity or other cardiometabolic conditions.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [143]

    The Discussion links berberine to protection from cardiac dysfunction in GDM-exposed mouse offspring through improved cardiac mitochondrial function, and the Introduction reports reduced adiposity with berberine treatment. But the Abstract says berberine was given to the offspring at weaning, not administered to their mothers. The paper therefore supports a possible protective effect of a natural compound, but not the claimed maternal route of administration. (LLM, conf=0.89)

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References 29 · Cited by 17

Research works printed but not linked: 24

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Authors
Cole, L. K., Sparagna, G. C., Vandel, M., Xiang, B., Dolinsky, V. W., & Hatch, G. M.
Affiliations
  • Children's Hospital Research Institute of Manitoba (CA)
  • University of Colorado Anschutz (US)
Corresponding author
Hatch, Grant M.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-08-04
Volume
11
Issue
1
Pages
15770-15770
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-021-95353-4
PMC
PMC8338981
OpenAlex
W3187780734
Cited by
17
References
29
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 1
FWCI
1.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Canadian Institutes of Health Research
  • Heart and Stroke Foundation of Canada
Topics
  • Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
berberine, cardiolipin, gestational diabetes mellitus, high-fat diet, mitochondrial phospholipids, tafazzin, cardiac mitochondrial function, fatty acid oxidation, electron transport chain
MeSH terms
Acyltransferases, Animals, Berberine, Cardiolipins, Electron Transport, Fatty Acids, Female, Heart Diseases, Male, Maternal-Fetal Exchange, Mice, Inbred C57BL, Mitochondria, Heart, Myocardium, Oxidation-Reduction, Pregnancy, Gene Expression, Diabetes, Gestational, Mice, Diet, High-Fat

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