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Cited by 21Spatial Neglect and Hemispheric DysfunctionVirtual Reality Applications and ImpactsStroke Rehabilitation and Recovery

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Feasibility study of immersive virtual prism adaptation therapy with depth-sensing camera using functional near-infrared spectroscopy in healthy adults

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Cho, Sungmin, Chang, Won Kee, Park, Jihong, Lee, Seung Hyun, Lee, Jongseung, Han, Cheol E., Paik, Nam-Jong, Kim, Won-Seok·2022·Scientific Reports
DOI 10.1038/s41598-022-04771-5PMC PMC8760318

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Abstract

Prism Adaptation (PA) is used to alleviate spatial neglect. We combined immersive virtual reality with a depth-sensing camera to develop virtual prism adaptation therapy (VPAT), which block external visual cues and easily quantify and monitor errors than conventional PA. We conducted a feasibility study to investigate whether VPAT can induce behavioral adaptations by measuring after-effect and identifying which cortical areas were most significantly activated during VPAT using functional near-infrared spectroscopy (fNIRS). Fourteen healthy subjects participated in this study. The experiment consisted of four sequential phases (pre-VPAT, VPAT-10°, VPAT-20°, and post-VPAT). To compare the most significantly activated cortical areas during pointing in different phases against pointing during the pre-VPAT phase, we analyzed changes in oxyhemoglobin concentration using fNIRS during pointing. The pointing errors of the virtual hand deviated to the right-side during early pointing blocks in the VPAT-10° and VPAT-20° phases. There was a left-side deviation of the real hand to the target in the post-VPAT phase, demonstrating after-effect. The most significantly activated channels during pointing tasks were located in the right hemisphere, and possible corresponding cortical areas included the dorsolateral prefrontal cortex and frontal eye field. In conclusion, VPAT may induce behavioral adaptation with modulation of the dorsal attentional network.

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Metadata

Authors
Cho, S., Chang, W. K., Park, J., Lee, S. H., Lee, J., Han, C. E., Paik, N.-J., & Kim, W.-S.
Affiliations
  • Seoul National University (KR)
  • Korea University (KR)
Corresponding author
Kim, Won-Seok
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2022-01-14
Volume
12
Issue
1
Pages
767-767
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-022-04771-5
PMC
PMC8760318
OpenAlex
W4205830383
Cited by
21
References
65
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 1
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
  • Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1A2B4013730, 2015R1C1A1A01054629)
  • SNUBH Research Fund (20-2016-032)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
  • Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
hemispatial neglect, immersive virtual reality, depth camera, dorsolateral prefrontal cortex, frontal eye field, oxyhemoglobin concentration, pointing errors, cortical activation, healthy adults
MeSH terms
Adaptation, Psychological, Adult, Attention, Behavior, Cerebral Cortex, Cues, Feasibility Studies, Female, Humans, Male, Oxyhemoglobins, Spectroscopy, Near-Infrared, Young Adult, Virtual Reality Exposure Therapy, Healthy Volunteers

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