NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
Open accessAbstract
Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.
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Multiple senescence transcriptional gene sets have been described.
“A senescence transcriptional signature could enable rapid detection of senescent cells, and multiple such gene sets have been described132–136,139.”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [139]
The 'Characterization of senescent cells' section lists individual biomarkers and predicts that multiple overlapping senescence signatures will ultimately be identified. It does not say that multiple transcriptional gene sets have already been described (searched: transcriptional signatures, gene sets, and transcriptomic profiles). The indexed passages provide no page numbers. (LLM, conf=0.72)
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References 61 · Cited by 122
- Authors
- SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., Ding, L., Duncan, F. E., Eickelberg, O., Fan, R., Finkel, T., Furman, D., Garovic, V., Gehlenborg, N., Glass, C., Heckenbach, I., Joseph, Z.-B., Katiyar, P., Kim, S.-J., Königshoff, M., Kuchel, G. A., Lee, H., Lee, J. H., Ma, J., Ma, Q., Melov, S., Metis, K., Mora, A. L., Musi, N., Neretti, N., Passos, J. F., Rahman, I., Rivera-Mulia, J. C., Robson, P., Rojas, M., Roy, A. L., Scheibye-Knudsen, M., Schilling, B., Shi, P., Silverstein, J. C., Suryadevara, V., Xie, J., Wang, J., Wong, A. I., Niedernhofer, L. J., Brown University TDA, Wang, S., Buck Institute for Research on Aging TMC/TDA, Anvari, H., Balough, J., Benz, C., Bons, J., Brenerman, B., Evans, W., Gerencser, A., Gregory, H., Hansen, M., Justice, J., Kapahi, P., Murad, N., O’Broin, A., Pavone, M. E., Powell, M., Scott, G., Shanes, E., Shankaran, M., Verdin, E., Winer, D., Wu, F., Consortium Organization and Data Coordinating Center (CODCC), Adams, A., Blood, P. D., Bueckle, A., Cao-Berg, I., Chen, H., Davis, M., Filus, S., Hao, Y., Hartman, A., Hasanaj, E., Helfer, J., Herr, B., Joseph, Z. B., Molla, G., Mou, G., Puerto, J., Quardokus, E. M., Ropelewski, A. J., Ruffalo, M., Satija, R., Schwenk, M., Scibek, R., Shirey, W., Sibilla, M., Welling, J., Yuan, Z., Columbia, T. M. C., Bonneau, R., Christiano, A., Izar, B., Menon, V., Owens, D. M., Phatnani, H., Smith, C., Suh, Y., Teich, A. F., Duke University TMC, Bekker, V., Chan, C., Coutavas, E., Hartwig, M. G., Ji, Z., Nixon, A. B., Massachusetts General Hospital, T. D. A., Dou, Z., Rajagopal, J., Slavov, N., Mayo Clinic, T. D. A., Holmes, D., Jurk, D., Kirkland, J. L., Lagnado, A., Tchkonia, T., National Institute of Health (NIH), Abraham, K., Dibattista, A., Fridell, Y.-W., Howcroft, T. K., Jhappan, C., Montes, V. P., Prabhudas, M., Resat, H., Taylor, V., Stanford, T. D. A., Kumar, M., Suryadevara, V., University of Connecticut TMC, Cigarroa, F., Cohn, R., Cortes, T. M., Courtois, E., Chuang, J., Davé, M., Domanskyi, S., Enninga, E. A. L., Eryilmaz, G. N., Espinoza, S. E., Gelfond, J., Kirkland, J., Kuchel, G. A., Kuo, C.-L., Lehman, J. S., Aguayo-Mazzucato, C., Meves, A., Rani, M., Sanders, S., Thibodeau, A., Tullius, S. G., Ucar, D., White, B., Wu, Q., Xu, M., Yamaguchi, S., University of Michigan TDA, Assarzadegan, N., Cho, C.-S., Hwang, I., Hwang, Y., Xi, J., University of Minnesota TMC, Adeyi, O. A., Aliferis, C. F., Bartolomucci, A., Dong, X., DuFresne-To, M. J., Ikramuddin, S., Johnson, S. G., Nelson, A. C., Niedernhofer, L. J., Revelo, X. S., Trevilla-Garcia, C., Sedivy, J. M., Thompson, E. L., Robbins, P. D., Wang, J., University of Pittsburgh TMC, Aird, K. M., Alder, J. K., Beaulieu, D., Bueno, M., Calyeca, J., Chamucero-Millaris, J. A., Chan, S. Y., Chung, D., Corbett, A., Gorbunova, V., Gowdy, K. M., Gurkar, A., Horowitz, J. C., Hu, Q., Kaur, G., Khaliullin, T. O., Lafyatis, R., Lanna, S., Li, D., Ma, A., Morris, A., Muthumalage, T. M., Peters, V., Pryhuber, G. S., Reader, B. F., Rosas, L., Sembrat, J. C., Shaikh, S., Shi, H., Stacey, S. D., Croix, C. S., Wang, C., Wang, Q., Watts, A., University of Washington TDA, Gu, L., Lin, Y., Rabinovitch, P. S., Sweetwyne, M. T., Washington University TMC, Artyomov, M. N., Ballentine, S. J., Chheda, M. G., Davies, S. R., DiPersio, J. F., Fields, R. C., Fitzpatrick, J. A. J., Fulton, R. S., Imai, S.-I., Jain, S., Ju, T., Kushnir, V. M., Link, D. C., Ben Major, M., Oh, S. T., Rapp, D., Rettig, M. P., Stewart, S. A., Veis, D. J., Vij, K. R., Wendl, M. C., Wyczalkowski, M. A., Yale, T. M. C., Craft, J. E., Enninful, A., Farzad, N., Gershkovich, P., Halene, S., Kluger, Y., VanOudenhove, J., Xu, M., Yang, J., & Yang, M.
- Affiliations
- Duke University (US)
- Buck Institute for Research on Aging (US)
- Washington University in St. Louis (US)
- Columbia University (US)
- Northwestern University (US)
- University of Pittsburgh (US)
- Mayo Clinic (US)
- Harvard University (US)
- National Institutes of Health (US)
- University of Michigan (US)
- The Ohio State University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Minnesota (US)
- Jackson Laboratory (US)
- University of Copenhagen (DK)
- Pittsburgh Supercomputing Center (US)
- New York Genome Center (US)
- Indiana University Bloomington (US)
- Columbia University Irving Medical Center (US)
- Northeastern University (US)
- University of Connecticut (US)
- UConn Health (US)
- Brigham and Women's Hospital (US)
- University of Rochester Medicine (US)
- The Ohio State University Wexner Medical Center (US)
- University of Washington (US)
- Yale University (US)
- Corresponding author
- Lee, Patty J.
- ORCID
- Lee, Patty J.
- Börner, Katy
- Campisi, Judith
- Chen, Feng
- Daldrup-Link, Heike
- Ding, Li
- Duncan, Francesca E.
- Eickelberg, Oliver
- Finkel, Toren
- Furman, David
- Garovic, Vesna
- Gehlenborg, Nils
- Glass, Carolyn
- Heckenbach, Indra
- Lee, Jun Hee
- Ma, Jian
- Ma, Qin
- Melov, Simon
- Mora, Ana L.
- Musi, Nicolas
- Neretti, Nicola
- Passos, João F.
- Rahman, Irfan
- Robson, Paul
- Rojas, Mauricio
- Roy, Ananda L.
- Schilling, Birgit
- Shi, Pixu
- Silverstein, Jonathan C.
- Xie, Jichun
- Wang, Siyuan
- Anvari, Hannah
- Balough, Julia
- Bons, Joanna
- Brenerman, Boris
- Evans, William
- Gerencser, Akos
- Hansen, Malene
- Justice, Jamie
- Kapahi, Pankaj
- O’Broin, Amy
- Pavone, Mary Ellen
- Powell, Mark
- Shanes, Elisheva
- Shankaran, Mahalakshmi
- Verdin, Eric
- Winer, Daniel
- Wu, Fei
- Bueckle, Andreas
- Cao-Berg, Ivan
- Chen, Hao
- Davis, Michael
- Filus, Shane
- Hao, Yuhan
- Hartman, Austin
- Hasanaj, Euxhen
- Herr, Bruce
- Molla, Gesmira
- Puerto, Juan
- Quardokus, Ellen M.
- Ropelewski, Alexander J.
- Satija, Rahul
- Sibilla, Max
- Welling, Joel
- Bonneau, Richard
- Christiano, Angela
- Izar, Benjamin
- Menon, Vilas
- Owens, David M.
- Phatnani, Hemali
- Smith, Colin
- Suh, Yousin
- Teich, Andrew F.
- Bekker, Valerie
- Chan, Cliburn
- Coutavas, Elias
- Hartwig, Matthew G.
- Nixon, Andrew B.
- Dou, Zhixun
- Rajagopal, Jayaraj
- Slavov, Nikolai
- Jurk, Diana
- Lagnado, Anthony
- Dibattista, Amanda
- Prabhudas, Mercy
- Resat, Haluk
- Kumar, Manoj
- Cigarroa, Francisco
- Cortes, Tiffany M.
- Courtois, Elise
- Chuang, Jeffrey
- Davé, Monica
- Domanskyi, Sergii
- Enninga, Elizabeth Ann Lieser
- Eryilmaz, Giray Naim
- Espinoza, Sara E.
- Kuo, Chia-Ling
- Lehman, Julia S.
- Meves, Alexander
- Thibodeau, Asa
- Tullius, Stefan G.
- Ucar, Duygu
- White, Brian
- Xu, Ming
- Yamaguchi, Seiji
- Assarzadegan, Naziheh
- Cho, Chun-Seok
- Hwang, Irene
- Adeyi, Oyedele A.
- Aliferis, Constantin F.
- Bartolomucci, Alessandro
- Dong, Xiao
- DuFresne-To, Mickayla J.
- Ikramuddin, Sayeed
- Johnson, Steve G.
- Revelo, Xavier S.
- Sedivy, John M.
- Robbins, Paul D.
- Aird, Katherine M.
- Alder, Jonathan K.
- Beaulieu, Delphine
- Bueno, Marta
- Chan, Stephen Y.
- Chung, Dongjun
- Corbett, Anthony
- Gorbunova, Vera
- Gowdy, Kymberly M.
- Gurkar, Aditi
- Horowitz, Jeffrey C.
- Hu, Qianjiang
- Kaur, Gagandeep
- Lafyatis, Robert
- Li, Dongmei
- Ma, Anjun
- Muthumalage, Thivanka M.
- Peters, Victor
- Pryhuber, Gloria S.
- Reader, Brenda F.
- Rosas, Lorena
- Sembrat, John C.
- Shaikh, Sadiya
- Shi, Hangchuan
- Stacey, Sean D.
- Wang, Cankun
- Wang, Qixin
- Gu, Liangcai
- Lin, Yiing
- Rabinovitch, Peter S.
- Sweetwyne, Mariya T.
- Artyomov, Maxim N.
- Ballentine, Samuel J.
- Chheda, Milan G.
- Davies, Sherri R.
- DiPersio, John F.
- Fields, Ryan C.
- Fitzpatrick, James A. J.
- Fulton, Robert S.
- Imai, Shin-ichiro
- Jain, Sanjay
- Ju, Tao
- Kushnir, Vladimir M.
- Link, Daniel C.
- Oh, Stephen T.
- Rettig, Michael P.
- Vij, Kiran R.
- Wendl, Michael C.
- Wyczalkowski, Matthew A.
- Craft, Joseph E.
- Enninful, Archibald
- Farzad, Negin
- Halene, Stephanie
- Kluger, Yuval
- VanOudenhove, Jennifer
- Xu, Mina
- Yang, Junchen
- Venue
- Nature Aging
- Published
- 2022-12-20
- Volume
- 2
- Issue
- 12
- Pages
- 1090-1100
- ISSN
- 2662-8465 (ISSN-L)
- PMC
- PMC10019484
- OpenAlex
- W4313449211
- Cited by
- 122
- References
- 61
- Citations by year
- 2026: 27 · 2025: 30 · 2024: 44 · 2023: 21
- FWCI
- 14.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Aging (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (1U54AG075936-01, 1U54AG075932-01, 1U54AG075934-01, 1U54AG076043-01, 1U54AG075931-01, 1U54AG075941-01, 1U54AG076041-01)
- Center for Strategic Scientific Initiatives, National Cancer Institute (1U24CA268108-01, 1UG3CA268112-01, 1UG3CA268091-01, 1UG3CA268202-01, 1UG3CA268105-01, 1UG3CA268103-01)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- cellular senescence, senescent cells, senescence-associated secretory phenotype, human lifespan, senescence biomarkers, multi-omics, aging, growth arrest
- MeSH terms
- Humans, Longevity, United States, Biomarkers, Cellular Senescence
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