SEA-AD is a multimodal cellular atlas and resource for Alzheimer’s disease
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Stratifying human astrocyte transcriptomes from four published single-nuclei datasets by APOE genotype revealed differential expression patterns consistent with our proteomics data.
“We analyzed human astrocyte transcriptomes taken from four published single-nuclei transcriptomic datasets to determine whether genotype-specific lipid droplet proteome changes are reflected in post-mortem brain samples51–54.”
From APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics (2026) · cites this paper as [51]
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2023 Alzheimer's disease facts and figures
(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212 · see citing works
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
Self-citationIntegrated multimodal cell atlas of Alzheimer’s disease
Gabitto, M. I., Travaglini, K. J., Rachleff, V. M., Kaplan, E. S., Long, B., Ariza, J., Ding, Y., Mahoney, J. T., Dee, N., Goldy, J., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01774-5 · Cited by 397 · see citing works
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Cuní-López, C., Root, J. T., Hao, Y., Blomberg, N., Koppes-den Hertog, S. J., Sacks, D., Trujillo, A. E., Ghirlando, R., Kowal, I., Epstein, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76565-6
- Authors
- Hawrylycz, M., Kaplan, E. S., Travaglini, K. J., Gabitto, M. I., Miller, J. A., Ng, L., Close, J. L., Hodge, R. D., Long, B., Mollenkopf, T., Mufti, S., Gatto, N. M., Larson, E. B., Crane, P. K., Grabowski, T. J., Keene, C. D., & Lein, E. S.
- Affiliations
- Allen Institute for Brain Science (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University of Washington (US)
- Corresponding author
- Hawrylycz, Michael
- Lein, Ed S.
- ORCID
- Venue
- Nature Aging
- Published
- 2024-10-14
- Volume
- 4
- Issue
- 10
- Pages
- 1331-1334
- ISSN
- 2662-8465 (ISSN-L)
- PMC
- PMC11577961
- OpenAlex
- W4403401418
- Cited by
- 47
- References
- 3
- Citations by year
- 2026: 29 · 2025: 17 · 2024: 1
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (U19AG060909, U01AG006781, U19AG066567, P50AG005136, P30AG066509)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, single-cell genomics, spatial genomics, neuropathology, dementia, cellular pathology, molecular pathology, open data resources
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