CRISPR engineering in organoids for gene repair and disease modelling
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CRISPR-Cas9-mediated genome engineering has extensively been used to model or repair mutations in ASC organoids.
“CRISPR-Cas9-mediated genome engineering has extensively been used to model or repair mutations in ASC organoids.1”
From Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools (2024) · cites this paper as [1]
CRISPR/Cas9 has emerged as an efficient strategy for genome engineering and has been successfully used in model systems, including organoids, to study tumorigenesis.
“CRISPR/Cas9 has emerged as an efficient strategy for genome engineering and has been successfully used in model systems, including organoids, to study tumorigenesis13–16.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [16]
The citation lists haven’t been fetched yet
References 156 · Cited by 103
- Authors
- Geurts, M. H., & Clevers, H.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Clevers, Hans
- Venue
- Nature Reviews Bioengineering
- Published
- 2023-01-19
- Volume
- 1
- Issue
- 1
- Pages
- 32-45
- ISSN
- 2731-6092 (ISSN-L)
- OpenAlex
- W4317434039
- Cited by
- 103
- References
- 156
- Citations by year
- 2026: 25 · 2025: 43 · 2024: 32 · 2023: 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Bioengineering (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- organoids, monogenic disorders, base editing, prime editing, gene repair, allelic variants, tissue transplantation, 3D tissue models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
