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Cited by 55

miRNA expression atlas in male rat

Minami, Keiichi, Uehara, Takeki, Morikawa, Yuji, Omura, Ko, Kanki, Masayuki, Horinouchi, Akira, Ono, Atsushi, Yamada, Hiroshi +2 more·2014·Scientific Data
DOI 10.1038/sdata.2014.5PMC PMC4322570
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Abstract

MicroRNAs (miRNAs) are small (~22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

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  • When comparing their data to a dataset on 55 different rat tissues (GEO, 8), they confirmed conserved tissue-specific expression of several miRNAs, including miR-133b, miR-124 and miR-9.

    “When we compared our data to a data set on 55 different rat tissues available at GEO database (8), we could confirm conserved tissue-specific expression of several miRNAs, including miR-133b, miR-124 and miR-9.”

    From Distribution of miRNA expression across human tissues (2016) · cites this paper as [8]

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Cited by

Sorted by citations

Authors
Minami, K., Uehara, T., Morikawa, Y., Omura, K., Kanki, M., Horinouchi, A., Ono, A., Yamada, H., Ohno, Y., & Urushidani, T.
Venue
Scientific Data
Publisher
Springer Science and Business Media LLC
Published
2014-05-27
Volume
1
Issue
1
ISSN
2052-4463
DOI
10.1038/sdata.2014.5
PMC
PMC4322570
Cited by
55
References
3
Language
en
Licence

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