The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
Open accessAbstract
Akt/PKB is a serine/threonine protein kinase that regulates cell cycle progression, apoptosis and growth factor mediated cell survival in association with tyrosine kinase receptors. The protein is a downstream effector of erbB-2 with implications in breast cancer progression and drug resistance in vitro. We aimed to examine the role of Akt-1 in breast cancer patients, by determining whether the expression (Akt-1) and/or activation (pAkt) were related to prognostic markers and survival. The expression of erbB-2, heregulin beta 1 and Bcl-2 was also assessed by flow cytometry or immunohistochemistry. This study comprised 93 patients, aged <50 who were treated with tamoxifen and/or goserelin. We found that pAkt was associated with lower S-phase fraction (P=0.001) and the presence of heregulin beta 1-expressing stromal cells (P=0.017). Neither Akt-1 nor pAkt was related with other factors. Tumour cells-derived heregulin beta 1 was found mainly in oestrogen receptor negative (P=0.026) and node negative (P=0.005) cases. Survival analysis revealed that pAkt positive patients were more prone to relapse with distant metastasis, independently of S-phase fraction and nodal status (multivariate analysis; P=0.004). The results suggest that activation of Akt may have prognostic relevance in breast cancer.
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Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Levy, R. B., & Yarden, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90131-u · Cited by 524
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Sunters, A., Fernández de Mattos, S., Stahl, M., Brosens, J. J., Zoumpoulidou, G., Saunders, C. A., Coffer, P. J., Medema, R. H., Coombes, R. C., & Lam, E. W.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309523200 · Cited by 505
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Ridnour, L. A., Barasch, K. M., Windhausen, A. N., Dorsey, T. H., Lizardo, M. M., Yfantis, H. G., Lee, D. H., Switzer, C. H., Cheng, R. Y. S., Heinecke, J. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044081 · Cited by 71
Metadata
- Authors
- and members of the Southeast Sweden Breast Cancer Group, Pérez-Tenorio, G., & Stål, O.
- Venue
- British Journal of Cancer
- Published
- 2002-02
- Volume
- 86
- Issue
- 4
- Pages
- 540-545
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2029882446
- Cited by
- 394
- References
- 1
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- and members of the Southeast Sweden Breast Cancer Group, Pérez-Tenorio, G., & Stål, O. (2002). Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6600126
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