The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
Open accessAbstract
mTOR is a downstream mediator in the PI3K/Akt signalling pathway, which plays a critical role in regulating basic cellular functions. These include cell proliferation, survival, mobility and angiogenesis. Rapamycin and its analogues (CCI-779, RAD001 and AP23573) have specific antagonistic action on the function of mTOR. This leads to inhibition of the downstream signalling elements and results in the cell cycle arrest in the G1 phase. This group of drugs may have a place in Oncology for the treatment of cancers, which occur as a result of increased activity of the PI3 kinase/Akt/m-TOR pathway. The basic structure of the pathway was reviewed in this article, together with results of the clinical studies targeting mTOR for cancer therapy. This is an exciting area for development and poses many challenges to researchers.
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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
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The Akt/PKB pathway: molecular target for cancer drug discovery
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Drug/device combinations for local drug therapies and infection prophylaxis
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Metadata
- Authors
- Chan, S.
- Venue
- British Journal of Cancer
- Published
- 2004-09-14
- Volume
- 91
- Issue
- 8
- Pages
- 1420-1424
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2013453542
- Cited by
- 301
- References
- 23
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
