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Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome
Open accessAbstract
Post-mastectomy pain syndrome (PMPS) is a recognised complication of breast surgery although little is known about the long-term outcome of this chronic pain condition. In 1996, Smith et al identified a prevalence rate of PMPS of 43% among 408 women in the Grampian Region, Northeast Scotland. The aim of this study was to assess long-term outcome at 7-12 years postoperatively in this cohort of women, to describe the natural history of PMPS and impact of pain upon quality of life. Chronic pain and quality of life were assessed using the McGill Pain Questionnaire (MPQ) and Short Form-36 (SF-36). Of 175 women reporting PMPS in 1996, 138 were eligible for questionnaire follow-up in 2002. Mean time since surgery was 9 years (s.d. 1.8 years). A response rate of 82% (113 out of 138) was achieved; 59 out of 113 (52%) women reported continued PMPS and 54 out of 113 (48%) women reported their PMPS had resolved since the previous survey in 1996. Quality of life scores were significantly lower in women with persistent PMPS compared to those women whose pain had resolved. However, for women with persistent PMPS, SF-36 scores had improved over time. Risk factors for persistent PMPS included younger age and heavier weight. This study found that, of women reporting PMPS in 1996, half of those surveyed in 2002 continued to experience PMPS at a mean of 9 years after surgery.
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“Breast cancer is the most common form of cancer among women [1], and a majority of women report persistent psychological and physiological symptoms after breast cancer surgery [3–5].”
From Pre- and post-operative psychological interventions to prevent pain and fatigue after breast cancer surgery (PREVENT): Protocol for a randomized controlled trial (2022) · cites this paper as [5]
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- Macdonald, L., Bruce, J., Scott, N. W., Smith, W. C. S., & Chambers, W. A.
- Affiliations
- Aberdeen Royal Infirmary (GB)
- University of Aberdeen (GB)
- Corresponding author
- Bruce, J
- Venue
- British Journal of Cancer
- Published
- 2005-01
- Volume
- 92
- Issue
- 2
- Pages
- 225-230
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2361843
- OpenAlex
- W2070855246
- Cited by
- 338
- References
- 32
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 9 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 12 · 2019: 21 · 2018: 18 · 2017: 14 · 2016: 30 · 2015: 14 · 2014: 21 · 2013: 24 · 2012: 25
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Surgery › Breast Implant and Reconstruction
- Keywords
- post-mastectomy pain syndrome, breast cancer survivors, long-term outcomes, chronic pain, quality of life, natural history of pain, risk factors, age, body weight, breast surgery complications
- MeSH terms
- Age Factors, Body Weight, Breast Neoplasms, Follow-Up Studies, Humans, Male, Mastectomy, Middle Aged, Pain, Prognosis, Quality of Life, Surveys and Questionnaires, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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