Papillomavirus infection in rural women in southern India
Open accessAbstract
To investigate the prevalence of, and the risk factors for, cervical infection with 44 types of human papillomavirus (HPV) in a rural area in the Dindigul District, Tamil Nadu, India, we interviewed and obtained cervical cell samples from 1891 married women aged 16-59 years. HPV prevalence was 16.9% overall and 14.0% among women without cervical abnormalities, or 17.7 and 15.2%, respectively, age-standardised to the world standard population. In all, 21.9% of infections involved more than one HPV type. High-risk HPV types predominated, particularly HPV 16 (22.5% of women infected), followed by HPV 56, HPV 31, HPV 33 and HPV 18. Unlike most populations studied in developed countries, HPV prevalence was constant across the age groups. HPV positivity was inversely associated with education level (odds ratio (OR) among women with high school vs no education=0.6) and positively associated with widowhood and divorce (OR=1.7), nulligravidity (OR=2.3), and condom use (OR=2.6). It is unclear how much low clearance of, or frequent reinfection with HPV accounted for the study prevalence of infection in different age groups.
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EpiMetHeos was calibrated to Tamil Nadu to represent states in the high cervical cancer incidence cluster and to West Bengal to represent states in the low cervical cancer incidence cluster.
“we calibrated EpiMetHeos to the state of Tamil Nadu to represent the states in the high cancer incidence cluster, and the state of West Bengal to represent the states in the low cancer incidence cluster”
From Evidence-based impact projections of single-dose human papillomavirus vaccination in India: a modelling study (2022) · cites this paper as [19]
Materials and Methods identifies the study site as Dindigul District, Tamil Nadu, and the Discussion compares its HPV prevalence with that in high-risk cervical-cancer areas. The Discussion also mentions a West Bengal HPV survey, but does not classify West Bengal as a low-incidence state or establish high- and low-incidence state clusters. The EpiMetHeos calibration is the citing authors’ own action, not a finding of this source. (LLM, conf=0.78)
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References 17 · Cited by 163
Research works printed but not linked: 17
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- Authors
- Franceschi, S., Rajkumar, R., Snijders, P. J. F., Arslan, A., Mahé, C., Plummer, M., Sankaranarayanan, R., Cherian, J., Meijer, C. J. L. M., & Weiderpass, E.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Karolinska Institutet (SE)
- Corresponding author
- Franceschi, S
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2005-01-25
- Volume
- 92
- Issue
- 3
- Pages
- 601-606
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2362069
- OpenAlex
- W2050553573
- Cited by
- 163
- References
- 17
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 12
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Swiss Bridge Foundation
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, HPV prevalence, cervical infection, rural women, risk factors, HPV16, multiple HPV infection, high-risk HPV, educational attainment, marital status, condom use, Dindigul district
- MeSH terms
- Adolescent, Adult, Uterine Cervical Diseases, DNA, Viral, Educational Status, Female, Humans, India, Middle Aged, Rural Population, Vaginal Smears, Prevalence, Papillomavirus Infections
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