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mTOR signaling: implications for cancer and anticancer therapy

Petroulakis, E, Mamane, Y, Le Bacquer, O, Shahbazian, D, Sonenberg, N·2006·British Journal of Cancer
DOI 10.1038/sj.bjc.6602902PMC PMC2361102
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Figure 1 mTOR signaling to translation initiation. mTOR signaling regulates translation initiation by integrating several different inputs. Insulin, hormones and growth factors activate the PI3K/Akt signaling cascade. Akt receives inputs from PDK1 and the rictor/GβL/mTOR complex. Energy status (the AMP/ATP ratio) modulates AMPK activity. These pathways affect TSC1/2 to regulate mTOR activity via Rheb. The raptor/GβL/mTOR complex mediates the phosphorylation of 4E-BP and S6K. Pharmacological inhibition of PI3K (wortmannin or LY294002) and mTOR (rapamycin or its analogs), or activation of AMPK (by increased AMP/ATP, metformin or AICAR) are indicated.
Figure 1 mTOR signaling to translation initiation. mTOR signaling regulates translation initiation by integrating several different inputs. Insulin, hormones and growth factors activate the PI3K/Akt signaling cascade. Akt receives inputs from PDK1 and the rictor/GβL/mTOR complex. Energy status (the AMP/ATP ratio) modulates AMPK activity. These pathways affect TSC1/2 to regulate mTOR activity via Rheb. The raptor/GβL/mTOR complex mediates the phosphorylation of 4E-BP and S6K. Pharmacological inhibition of PI3K (wortmannin or LY294002) and mTOR (rapamycin or its analogs), or activation of AMPK (by increased AMP/ATP, metformin or AICAR) are indicated.CC BY · PubMed Central

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Research works printed but not linked: 37

  1. Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, Manivel JC, Sonenberg N, Yee D, Bitterman PB, Polunovsky VA (2004) Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5: 553–563 · DOI
  2. Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA (2002) Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419: 162–167 · DOI
  3. Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G (2005) The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120: 747–759 · DOI
  4. Burchert A, Wang Y, Cai D, von Bubnoff N, Paschka P, Muller-Brusselbach S, Ottmann OG, Duyster J, Hochhaus A, Neubauer A (2005) Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development. Leukemia 19: 1774–1782 · DOI
  5. Chen CZ (2005) MicroRNAs as oncogenes and tumor suppressors. N Engl J Med 353: 1768–1771 · DOI
  6. De Benedetti A, Graff JR (2004) eIF-4E expression and its role in malignancies and metastases. Oncogene 23: 3189–3199 · DOI
  7. Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC, Houghton PJ (2002) 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. J Biol Chem 277: 13907–13917 · DOI
  8. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304–1305 · DOI · Paper page
  9. Fumagalli S, Thomas G (2000) S6 phosphorylation and signal transduction. In Translational Control of Gene Expression, Sonenberg N, Hershey JWB and Mathews MB (eds) pp 695–717. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York
  10. Gingras AC, Raught B, Sonenberg N (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68: 913–963 · DOI
  11. Goudar RK, Shi Q, Hjelmeland MD, Keir ST, McLendon RE, Wikstrand CJ, Reese ED, Conrad CA, Traxler P, Lane HA, Reardon DA, Cavenee WK, Wang XF, Bigner DD, Friedman HS, Rich JN (2005) Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 4: 101–112 · DOI
  12. Guertin DA, Sabatini DM (2005) An expanding role for mTOR in cancer. Trends Mol Med 11: 353–361 · DOI
  13. Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166: 213–223 · DOI
  14. Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926–1945 · DOI · Paper page
  15. Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905–909 · DOI
  16. Huang S, Houghton PJ (2002) Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr Opin Investig Drugs 3: 295–304
  17. Inoki K, Corradetti MN, Guan KL (2005a) Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37: 19–24 · DOI
  18. Inoki K, Ouyang H, Li Y, Guan KL (2005b) Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 69: 79–100 · DOI
  19. Kim DH, Sabatini DM (2004) Raptor and mTOR: subunits of a nutrient-sensitive complex. Curr Top Microbiol Immunol 279: 259–270
  20. Kwiatkowski DJ, Manning BD (2005) Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 14 (Suppl 2): R251–R258 · DOI · Paper page
  21. Lazaris-Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345: 544–547 · DOI
  22. Lorberg A, Hall MN (2004) TOR: the first 10 years. Curr Top Microbiol Immunol 279: 1–18
  23. Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (2005) Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121: 179–193 · DOI · Paper page
  24. Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW, Sonenberg N (2004) eIF4E – from translation to transformation. Oncogene 23: 3172–3179 · DOI
  25. Mohi MG, Boulton C, Gu TL, Sternberg DW, Neuberg D, Griffin JD, Gilliland DG, Neel BG (2004) Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. Proc Natl Acad Sci USA 101: 3130–3135 · DOI
  26. Mondesire WH, Jian W, Zhang H, Ensor J, Hung MC, Mills GB, Meric-Bernstam F (2004) Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells. Clin Cancer Res 10: 7031–7042 · DOI
  27. Oridate N, Kim HJ, Xu X, Lotan R (2005) Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin. Cancer Biol Ther 4: 318–323 · DOI
  28. Panwalkar A, Verstovsek S, Giles FJ (2004) Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer 100: 657–666 · DOI
  29. Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G (2004) S6K1(−/−)/S6K2(−/−) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 24: 3112–3124 · DOI
  30. Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W (2005) Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 309: 1573–1576 · DOI
  31. Proud CG (2004) mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun 313: 429–436 · DOI
  32. Raught B, Gingras AC, Gygi SP, Imataka H, Morino S, Gradi A, Aebersold R, Sonenberg N (2000) Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J 19: 434–444 · DOI
  33. Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW (2004) Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J 23: 1761–1769 · DOI
  34. Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP (2004) The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10: 484–486 · DOI
  35. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC (2004) The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6: 91–99 · DOI
  36. Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW (2004) Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428: 332–337 · DOI
  37. Xu RH, Pelicano H, Zhang H, Giles FJ, Keating MJ, Huang P (2005) Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. Leukemia 19: 2153–2158 · DOI

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Metadata

Authors
Petroulakis, E., Mamane, Y., Le Bacquer, O., Shahbazian, D., & Sonenberg, N.
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2005-12-13
Volume
94
Issue
2
Pages
195-199
ISSN
  • 0007-0920
  • 1532-1827
DOI
10.1038/sj.bjc.6602902
PMC
PMC2361102
Cited by
170
References
1
Language
en
Licence
www.springer.com/tdm (unspecified)

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