The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss
Open accessAbstract
The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.
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Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
Fearon, K. C. H., Falconer, J. S., Slater, C., McMillan, D. C., Ross, J. A., & Preston, T. (1998) · Annals of Surgery · doi:10.1097/00000658-199802000-00015 · Cited by 196
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Cited by
ESPEN guidelines on nutrition in cancer patients
Arends, J., Bachmann, P., Baracos, V., Barthelemy, N., Bertz, H., Bozzetti, F., Fearon, K., Hütterer, E., Isenring, E., Kaasa, S., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.07.015 · Cited by 3,114
ESPEN practical guideline: Clinical Nutrition in cancer
Muscaritoli, M., Arends, J., Bachmann, P., Baracos, V., Barthelemy, N., Bertz, H., Bozzetti, F., Hütterer, E., Isenring, E., Kaasa, S., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.02.005 · Cited by 1,702
Cancer Anorexia-Cachexia Syndrome: Current Issues in Research and Management
Inui, A. (2002) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.2.72 · Cited by 579
Cancer cachexia: Developing multimodal therapy for a multidimensional problem
Fearon, K. C. H. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.033 · Cited by 444
Prostaglandins and sickness behavior: Old story, new insights
Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135
Metadata
- Authors
- McMillan, D. C., Wigmore, S. J., Wigmore, K. C. H., O’Gorman, P., Wright, C. E., & McArdle, C. S.
- Venue
- British Journal of Cancer
- Published
- 1999-01-14
- Volume
- 79
- Issue
- 3-4
- Pages
- 495-500
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W1979855377
- Cited by
- 174
- References
- 3
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McMillan, D. C., Wigmore, S. J., Wigmore, K. C. H., O’Gorman, P., Wright, C. E., & McArdle, C. S. (1999). A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6690077
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
