Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

Hamacher-Brady, A; Brady, N R; Logue, S E; Sayen, M R; Jinno, M; Kirshenbaum, L A; Gottlieb, R A; Gustafsson, Å B

doi:10.1038/sj.cdd.4401936

Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

Ischemia and reperfusion (I/R) injury is associated with extensive loss of cardiac myocytes. Bnip3 is a mitochondrial pro-apoptotic Bcl-2 protein which is expressed in the adult myocardium. To investigate if Bnip3 plays a role in I/R injury, we generated a TAT-fusion protein encoding the carboxyl…