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The Prospects for “Personalized Medicine” in Drug Development and Drug Therapy
Abstract
There has been much recent discussion about the advent of "personalized medicine," but controversy exists over its exact definition; how, when, and whether it will be brought about, and what means could be used to measure its attainment. In fact, the concept of "personalized medicine" is a sort of shorthand used to represent the logical next steps in progression of medical science toward greater mechanistic understanding of health, disease, and treatment. This shorthand is attractive to the public because of its intuitive appeal, and irritating to the biomedical community because it glosses over the very real scientific and implementation challenges. This paper evaluates the trajectory and promise of these next steps for the currently problematic states of both drug development and therapy.
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Cited by
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Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., Persinger, C. C., Munos, B. H., Lindborg, S. R., & Schacht, A. L. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3078 · Cited by 3,566
The FDA Critical Path Initiative and Its Influence on New Drug Development
Woodcock, J., & Woosley, R. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.59.090506.155819 · Cited by 434
Self-citation’Personalized Medicine’: What’S in a Name?
Pokorska-Bocci, A., Stewart, A., Sagoo, G. S., Hall, A., Kroese, M., & Burton, H. (2014) · Personalized Medicine · doi:10.2217/pme.13.107 · Cited by 114
Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery
Braam, S. R., Passier, R., & Mummery, C. L. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.07.001 · Cited by 86
Rational prescribing: the principles of drug selection
Maxwell, S. (2009) · Clinical Medicine · doi:10.7861/clinmedicine.9-5-481 · Cited by 59
Metadata
- Authors
- Woodcock, J.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-02
- Volume
- 81
- Issue
- 2
- Pages
- 164-169
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2061827267
- Cited by
- 179
- References
- 0
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Woodcock, J. (2007). The Prospects for “Personalized Medicine” in Drug Development and Drug Therapy. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/sj.clpt.6100063
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
