The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics
Open accessAbstract
The goal of this study was to determine the effects of genetic variation in the organic cation transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty healthy volunteers with known OCT1 genotype agreed to participate in the study. Each subject received two oral doses of metformin followed by collection of blood and urine samples. OCT1 genotypes had a significant (P<0.05) effect on metformin pharmacokinetics, with a higher area under the plasma concentration-time curve (AUC), higher maximal plasma concentration (Cmax), and lower oral volume of distribution (V/F) in the individuals carrying a reduced function OCT1 allele (R61C, G401S, 420del, or G465R). The effect of OCT1 on metformin pharmacokinetics in mice was less than in humans possibly reflecting species differences in hepatic expression level of the transporter. Our studies suggest that OCT1 genotype is a determinant of metformin pharmacokinetics.
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Cites
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Cited by
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Metadata
- Authors
- Shu, Y., Brown, C., Castro, R., Shi, R., Lin, E., Owen, R., Sheardown, S., Yue, L., Burchard, E., Brett, C., & Giacomini, K.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-07-04
- Volume
- 83
- Issue
- 2
- Pages
- 273-280
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2086818413
- Cited by
- 477
- References
- 26
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics. https://app.cochat.ai/papers/10.1038/sj.clpt.6100275
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- Shu, Y., Brown, C., Castro, R., Shi, R., Lin, E., Owen, R., Sheardown, S., Yue, L., Burchard, E., Brett, C., & Giacomini, K. (2008). Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/sj.clpt.6100275
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
