Cited by 278Developmental Biology and Gene RegulationCleft Lip and Palate ResearchCraniofacial Disorders and Treatments

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Msx homeobox gene family and craniofacial development

ALAPPAT, Sylvia, ZHANG, Zun Yi, CHEN, Yi Ping·2003·Cell Research

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Abstract

Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the phenotypic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice. Key words: Msx genes, craniofacial, tooth, cleft palate, suture, development, transcription factor, signaling molecule.

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Authors: ALAPPAT, S., ZHANG, Z. Y., & CHEN, Y. P.
Affiliations: Tulane University (US)
Fujian Normal University (CN)
Corresponding author: CHEN, Yi Ping
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2003-12
Volume: 13
Issue: 6
Pages: 429-442
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/sj.cr.7290185
OpenAlex: W1991941177
Cited by: 278
References: 128
Citations by year: 2026: 6 · 2025: 7 · 2024: 10 · 2023: 14 · 2022: 12 · 2021: 18 · 2020: 12 · 2019: 11 · 2018: 16 · 2017: 8 · 2016: 16 · 2015: 16 · 2014: 16 · 2013: 13 · 2012: 19
FWCI: 0.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (9796321)
Louisiana Board of Regents (2000-05)
National Institutes of Health
National Institute of Dental and Craniofacial Research (R01 DE12329, R01DE014044, R01 DE14044, P60-DE 13076, R01DE012329, P60DE013076)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Dentistry › Oral Surgery › Cleft Lip and Palate Research
Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
Keywords: craniofacial development, tooth development, cleft palate, cranial sutures, limb development, tissue-tissue interactions, transcription factors, signaling molecules, gene expression regulation, knockout mice
MeSH terms: Animals, Cleft Palate, DNA-Binding Proteins, Ectoderm, Embryonic Induction, Genes, Homeobox, Humans, Maxillofacial Development, Mesoderm, Models, Biological, Morphogenesis, Mutation, Odontogenesis, Skull, Transcription Factors, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Mice, MSX1 Transcription Factor

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Msx homeobox gene family and craniofacial development

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