The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
New functions of XPC in the protection of human skin cells from oxidative damage
Open accessAbstract
Xeroderma pigmentosum (XP) C is involved in the recognition of a variety of bulky DNA-distorting lesions in nucleotide excision repair. Here, we show that XPC plays an unexpected and multifaceted role in cell protection from oxidative DNA damage. XP-C primary keratinocytes and fibroblasts are hypersensitive to the killing effects of DNA-oxidizing agents and this effect is reverted by expression of wild-type XPC. Upon oxidant exposure, XP-C primary keratinocytes and fibroblasts accumulate 8,5'-cyclopurine 2'-deoxynucleosides in their DNA, indicating that XPC is involved in their removal. In the absence of XPC, a decrease in the repair rate of 8-hydroxyguanine (8-OH-Gua) is also observed. We demonstrate that XPC-HR23B complex acts as cofactor in base excision repair of 8-OH-Gua, by stimulating the activity of its specific DNA glycosylase OGG1. In vitro experiments suggest that the mechanism involved is a combination of increased loading and turnover of OGG1 by XPC-HR23B complex. The accumulation of endogenous oxidative DNA damage might contribute to increased skin cancer risk and account for internal cancers reported for XP-C patients.
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“Additionally, studies using human keratinocytes and fibroblasts from XPC patients showed that this protein is important to prevent the accumulation of oxidatively generated DNA damage and its killing effects after exposure to oxidants, such as potassium bromate, X-rays, and methylene blue plus visible light [244,245,253].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [244]
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“In addition to the main role of the XPC complex in the recognition of DNA-distorting lesions, it has been demonstrated that it can functionally interact with several BER proteins, including 3-methyladenine DNA glycosylase, thymine DNA glycosylase (TDG), uracil-DNA glycosylases (UDG), apurinic/apyrimidinic endonuclease 1 (APE1), and 8-oxoguanine DNA glycosylase (OGG1) [244][245][246][247][248][249]”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [244]
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Metadata
- Authors
- D'Errico, M., Parlanti, E., Teson, M., de Jesus, B. M. B., Degan, P., Calcagnile, A., Jaruga, P., Bjørås, M., Crescenzi, M., Pedrini, A. M., Egly, J., Zambruno, G., Stefanini, M., Dizdaroglu, M., & Dogliotti, E.
- Affiliations
- Istituto Superiore di Sanità (IT)
- Istituto Dermopatico dell'Immacolata (IT)
- University of Oslo (NO)
- Istituto di Genetica Molecolare (IT)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- The EMBO Journal
- Published
- 2006-09-07
- Volume
- 25
- Issue
- 18
- Pages
- 4305-4315
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1570445
- OpenAlex
- W2062150992
- Cited by
- 271
- References
- 51
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 19 · 2020: 9 · 2019: 14 · 2018: 9 · 2017: 6 · 2016: 12 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 24
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Fondazione Cariplo
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- National Institute of Standards and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- XPC, xeroderma pigmentosum group C, oxidative DNA damage, base excision repair, 8-oxoguanine, OGG1, keratinocytes, fibroblasts, skin cancer risk, DNA glycosylase
- MeSH terms
- Bromates, Cells, Cultured, DNA Damage, DNA Repair, DNA-Binding Proteins, Guanine, Humans, Skin Neoplasms, X-Rays, Xeroderma Pigmentosum, Keratinocytes, Oxidants, DNA Repair Enzymes, DNA Glycosylases
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