The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
MAPK signalling: ERK5 versus ERK1/2
Open accessAbstract
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation motif. Both ERK5 and ERK1/2 are activated by growth factors and have an important role in the regulation of cell proliferation and cell differentiation. Moreover, both the ERK5 and the ERK1/2 pathways are sensitive to PD98059 and U0126, which are two well‐known inhibitors of the ERK pathway. Despite these similarities, recent studies have revealed distinctive features of the ERK5 pathway: ERK5 has a key role in cardiovascular development and neural differentiation; ERK5 nuclear translocation is controlled by its own nuclear localizing and nuclear export activities; and the carboxy‐terminal half of ERK5, which follows its kinase catalytic domain, has a unique function.
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Cites
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,382
Mitogen-activated protein kinase pathways
Robinson, M. J., & Cobb, M. H. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80061-0 · Cited by 2,474
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
The MAP kinase cascade is essential for diverse signal transduction pathways
Nishida, E., & Gotoh, Y. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90019-j · Cited by 1,076
Self-citationPhosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation
Khokhlatchev, A. V., Canagarajah, B., Wilsbacher, J., Robinson, M., Atkinson, M., Goldsmith, E., & Cobb, M. H. (1998) · Cell · doi:10.1016/s0092-8674(00)81189-7 · Cited by 677
Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice
Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., & Pouysségur, J. (1999) · Science · doi:10.1126/science.286.5443.1374 · Cited by 654
Components of a New Human Protein Kinase Signal Transduction Pathway
Zhou, G., Bao, Z. Q., & Dixon, J. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12665 · Cited by 639
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
Kato, Y. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7054 · Cited by 579
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Dodge-Kafka, K. L., Soughayer, J., Pare, G. C., Carlisle Michel, J. J., Langeberg, L. K., Kapiloff, M. S., & Scott, J. D. (2005) · Nature · doi:10.1038/nature03966 · Cited by 556
Cited by
ERK/MAPK signalling pathway and tumorigenesis (Review)
Guo, Y., Pan, W., Liu, S., Shen, Z., Xu, Y., & Hu, L. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8454 · Cited by 1,475
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139
Ji, R.-R., Gereau, R. W., Malcangio, M., & Strichartz, G. R. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.011 · Cited by 989
Keshet, Y., & Seger, R. (2010) · Methods in Molecular Biology · doi:10.1007/978-1-60761-795-2_1 · Cited by 642
The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
Rai, S. N., Dilnashin, H., Birla, H., Singh, S. S., Zahra, W., Rathore, A. S., Singh, B. K., & Singh, S. P. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-0003-y · Cited by 478
Metadata
- Authors
- Nishimoto, S., & Nishida, E.
- Venue
- EMBO reports
- Published
- 2006-08
- Volume
- 7
- Issue
- 8
- Pages
- 782-786
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2170242482
- Cited by
- 432
- References
- 70
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
