The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever‐dengue shock syndrome (DHF/DSS)
Open accessAbstract
The past four decades has witnessed a consolidation of the original observations made in the 1970s that dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) have an immunological basis. Following reinfection with a dengue virus of different serotype, severe disease is linked to high levels of antibody‐enhanced viral replication early in illness which is followed by a cascade of memory T‐cell activation and a ‘storm’ of inflammatory cytokines and other chemical mediators. These compounds are released mainly from T cells, monocytes/macrophages and endothelial cells, and ultimately cause an increase in vascular permeability. The consolidation of the evidence has been largely due to several important prospective sero‐epidemiological studies in areas endemic for DHF/DSS, which have shown that risk of severe disease is significantly higher in secondary dengue infections. These advances have underscored the fact that DHF/DSS pathogenesis is a complex, multifactorial process involving cocirculation of various dengue virus serotypes and the interplay of host and viral factors that influence disease severity. The continued search to define risk factors in susceptible populations must be combined with the new techniques of molecular virology and innovative approaches in vaccine design to achieve the ultimate objective of developing a safe and effective vaccine.
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Cites
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Cited by
Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation
Hottz, E. D., Lopes, J. F., Freitas, C., Valls-de-Souza, R., Oliveira, M. F., Bozza, M. T., Da Poian, A. T., Weyrich, A. S., Zimmerman, G. A., Bozza, F. A., et al. (2013) · Blood · doi:10.1182/blood-2013-05-504449 · Cited by 348
Whitehorn, J., & Simmons, C. P. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.07.022 · Cited by 282
Metadata
- Authors
- Pang, T., Cardosa, M. J., & Guzman, M. G.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2006-11-28
- Volume
- 85
- Issue
- 1
- Pages
- 43-45
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2000305555
- Cited by
- 272
- References
- 29
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever‐dengue shock syndrome (DHF/DSS). https://app.cochat.ai/papers/10.1038/sj.icb.7100008
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- Pang, T., Cardosa, M. J., & Guzman, M. G. (2007). Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever‐dengue shock syndrome (DHF/DSS). Immunology & Cell Biology. https://doi.org/10.1038/sj.icb.7100008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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